3Q4H
| Crystal structure of the Mycobacterium smegmatis EsxGH complex (MSMEG_0620-MSMEG_0621) | 分子名称: | Low molecular weight protein antigen 7, Pe family protein | 著者 | Chan, S, Harris, L, Kuo, E, Ahn, C, Zhou, T.T, Nguyen, L, Shin, A, Sawaya, M.R, Cascio, D, Arbing, M.A, Eisenberg, D, Integrated Center for Structure and Function Innovation (ISFI), TB Structural Genomics Consortium (TBSGC) | 登録日 | 2010-12-23 | 公開日 | 2011-01-26 | 最終更新日 | 2014-05-14 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Heterologous expression of mycobacterial Esx complexes in Escherichia coli for structural studies is facilitated by the use of maltose binding protein fusions. Plos One, 8, 2013
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5ZWV
| Structural Basis for the Enantioselectivity of Est-Y29 toward (S)-ketoprofen | 分子名称: | Est-Y29 | 著者 | Ngo, D.T, Oh, C, Park, K, Nguyen, L, Byun, H.M, Kim, S, Yoon, S, Ryu, Y, Ryu, B.H, Kim, T.D, Yang, J.W. | 登録日 | 2018-05-17 | 公開日 | 2019-03-13 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.099 Å) | 主引用文献 | Structural Basis for the Enantioselectivity of Esterase Est-Y29 toward (S)-Ketoprofen Acs Catalysis, 9, 2019
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5ZWR
| Structural Basis for the Enantioselectivity of Est-Y29 toward (S)-ketoprofen | 分子名称: | (2S)-2-[3-(benzenecarbonyl)phenyl]propanoic acid, Est-Y29, GLYCEROL | 著者 | Ngo, D.T, Oh, C, Park, K, Nguyen, L, Byun, H.M, Kim, S, Yoon, S, Ryu, Y, Ryu, B.H, Kim, T.D, Kim, K.K. | 登録日 | 2018-05-16 | 公開日 | 2019-03-13 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.69 Å) | 主引用文献 | Structural Basis for the Enantioselectivity of Esterase Est-Y29 toward (S)-Ketoprofen Acs Catalysis, 9, 2019
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5ZWQ
| Structural Basis for the Enantioselectivity of Est-Y29 toward (S)-ketoprofen | 分子名称: | Est-Y29, GLYCEROL, ethyl (2S)-2-[3-(benzenecarbonyl)phenyl]propanoate | 著者 | Ngo, D.T, Oh, C, Park, K, Nguyen, L, Byun, H.M, Kim, S, Yoon, S, Ryu, Y, Ryu, B.H, Kim, T.D, Yang, J.W, Kim, K.K. | 登録日 | 2018-05-16 | 公開日 | 2019-03-13 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.797 Å) | 主引用文献 | Structural Basis for the Enantioselectivity of Esterase Est-Y29 toward (S)-Ketoprofen Acs Catalysis, 9, 2019
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3BXY
| Crystal structure of tetrahydrodipicolinate N-succinyltransferase from E. coli | 分子名称: | 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase | 著者 | Kozlov, G, Gehring, K, Montreal-Kingston Bacterial Structural Genomics Initiative (BSGI) | 登録日 | 2008-01-15 | 公開日 | 2008-01-29 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structure of Escherichia coli tetrahydrodipicolinate N-succinyltransferase reveals the role of a conserved C-terminal helix in cooperative substrate binding. Febs Lett., 582, 2008
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7LBC
| Structure of human GGT1 in complex with Lnt2-65 compound | 分子名称: | (2R)-2-[(2-aminoethyl)amino]-4-boronobutanoic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... | 著者 | Terzyan, S.S, Hanigan, M. | 登録日 | 2021-01-07 | 公開日 | 2022-02-09 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.28 Å) | 主引用文献 | Design and evaluation of novel analogs of 2-amino-4-boronobutanoic acid (ABBA) as inhibitors of human gamma-glutamyl transpeptidase. Bioorg.Med.Chem., 73, 2022
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7LD9
| Structure of human GGT1 in complex with ABBA | 分子名称: | (2R)-2-amino-4-boronobutanoic acid, (2S)-2-amino-4-boronobutanoic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Terzyan, S.S, Hanigan, M. | 登録日 | 2021-01-12 | 公開日 | 2022-02-23 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.42 Å) | 主引用文献 | Design and evaluation of novel analogs of 2-amino-4-boronobutanoic acid (ABBA) as inhibitors of human gamma-glutamyl transpeptidase. Bioorg.Med.Chem., 73, 2022
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4OCZ
| Crystal structure of human soluble epoxide hydrolase complexed with 1-(1-isobutyrylpiperidin-4-yl)-3-(4-(trifluoromethyl)phenyl)urea | 分子名称: | 1-[1-(2-methylpropanoyl)piperidin-4-yl]-3-[4-(trifluoromethyl)phenyl]urea, Bifunctional epoxide hydrolase 2, MAGNESIUM ION, ... | 著者 | Lee, K.S.S, Liu, J, Wagner, K.M, Pakhomova, S, Dong, H, Morriseau, C, Fu, S.H, Yang, J, Wang, P, Ulu, A, Mate, C, Nguyen, L, Wullf, H, Eldin, M.L, Mara, A.A, Newcomer, M.E, Zeldin, D.C, Hammock, B.D. | 登録日 | 2014-01-09 | 公開日 | 2014-09-24 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.94 Å) | 主引用文献 | Optimized inhibitors of soluble epoxide hydrolase improve in vitro target residence time and in vivo efficacy. J.Med.Chem., 57, 2014
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2QHO
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3KUT
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3KUS
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3KUR
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6D7G
| Structure of 5F3 TCR in complex with HLA-A2/MART-1 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, MART1 PEPTIDE-BETA-2-MICROGLOBULIN-HLA-A*02 CHIMERA, T-CELL RECEPTOR GAMMA VARIABLE 8,T-CELL RECEPTOR GAMMA-2 CHAIN C REGION, ... | 著者 | Roy, S, Adams, E.J. | 登録日 | 2018-04-24 | 公開日 | 2019-01-23 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Generation and molecular recognition of melanoma-associated antigen-specific human gamma delta T cells. Sci Immunol, 3, 2018
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4OD0
| Crystal structure of human soluble epoxide hydrolase complexed with 1-(1-propanoylpiperidin-4-yl)-3-[4-(trifluoromethoxy)phenyl]urea | 分子名称: | 1-(1-propanoylpiperidin-4-yl)-3-[4-(trifluoromethoxy)phenyl]urea, Bifunctional epoxide hydrolase 2, MAGNESIUM ION, ... | 著者 | Lee, K.S.S, Liu, J, Wagner, K.M, Pakhomova, S, Dong, H, Morisseau, C, Fu, S.H, Yang, J, Wang, P, Ulu, A, Mate, C, Nguyen, L, Wullf, H, Eldin, M.L, Mara, A.A, Newcomer, M.E, Zeldin, D.C, Hammock, B.D. | 登録日 | 2014-01-09 | 公開日 | 2014-09-24 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.92 Å) | 主引用文献 | Optimized inhibitors of soluble epoxide hydrolase improve in vitro target residence time and in vivo efficacy. J.Med.Chem., 57, 2014
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6Z1C
| Crystal structure of Arabidopsis thaliana CK2-alpha-1 in complex with TTP-22 | 分子名称: | 3-[5-(4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl]sulfanylpropanoic acid, CHLORIDE ION, Casein kinase II subunit alpha-1 | 著者 | Demulder, M, Loris, R, De Veylder, L. | 登録日 | 2020-05-13 | 公開日 | 2021-03-24 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Arabidopsis casein kinase 2 triggers stem cell exhaustion under Al toxicity and phosphate deficiency through activating the DNA damage response pathway. Plant Cell, 33, 2021
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3OGI
| Crystal structure of the Mycobacterium tuberculosis H37Rv EsxOP complex (Rv2346c-Rv2347c) | 分子名称: | Putative ESAT-6-like protein 6, Putative ESAT-6-like protein 7 | 著者 | Arbing, M.A, Chan, S, Zhou, T.T, Ahn, C, Harris, L, Kuo, E, Sawaya, M.R, Cascio, D, Eisenberg, D, Integrated Center for Structure and Function Innovation (ISFI), TB Structural Genomics Consortium (TBSGC) | 登録日 | 2010-08-16 | 公開日 | 2010-08-25 | 最終更新日 | 2014-05-21 | 実験手法 | X-RAY DIFFRACTION (2.549 Å) | 主引用文献 | Heterologous expression of mycobacterial Esx complexes in Escherichia coli for structural studies is facilitated by the use of maltose binding protein fusions. Plos One, 8, 2013
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4ANW
| Complexes of PI3Kgamma with isoform selective inhibitors. | 分子名称: | 3-AMINO-6-{4-CHLORO-3-[(2,3-DIFLUOROPHENYL)SULFAMOYL]PHENYL}-N-METHYLPYRAZINE-2-CARBOXAMIDE, PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM, SULFATE ION | 著者 | Foster, P.G, Lougheed, J.C. | 登録日 | 2012-03-22 | 公開日 | 2012-05-09 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.31 Å) | 主引用文献 | The Discovery of a Novel Series of Potent and Orally Bioavailable Phosphoinositide 3-Kinase Gamma Inhibitors J.Med.Chem., 55, 2012
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4ANX
| Complexes of PI3Kgamma with isoform selective inhibitors. | 分子名称: | 5-{3-[(4-{3-[4-(1-methylethyl)phenyl]pyrazin-2-yl}piperazin-1-yl)sulfonyl]phenyl}pyrimidin-2-amine, PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM | 著者 | Foster, P.G, Lougheed, J.C. | 登録日 | 2012-03-22 | 公開日 | 2012-05-09 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.73 Å) | 主引用文献 | The Discovery of a Novel Series of Potent and Orally Bioavailable Phosphoinositide 3-Kinase Gamma Inhibitors J.Med.Chem., 55, 2012
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4ANV
| Complexes of PI3Kgamma with isoform selective inhibitors. | 分子名称: | 2-{4-[(4'-METHOXYBIPHENYL-3-YL)SULFONYL]PIPERAZIN-1-YL}-3-(4-METHOXYPHENYL)PYRAZINE, PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM, SULFATE ION | 著者 | Foster, P.G, Lougheed, J.C. | 登録日 | 2012-03-22 | 公開日 | 2012-05-09 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.13 Å) | 主引用文献 | The Discovery of a Novel Series of Potent and Orally Bioavailable Phosphoinositide 3-Kinase Gamma Inhibitors J.Med.Chem., 55, 2012
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6GMM
| Crystal structure of Helicobacter pylori adhesin LabA | 分子名称: | adhesin LabA | 著者 | Paraskevopoulou, V, Overman, R.C, Stolnik, S, Winkler, S, Gellert, P, Falcone, F.H, Schimpl, M. | 登録日 | 2018-05-27 | 公開日 | 2019-12-18 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.06 Å) | 主引用文献 | Structural and binding characterization of the LacdiNAc-specific adhesin (LabA; HopD) exodomain from Helicobacter pylori Current Research in Structural Biology, 2021
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4W2R
| Structure of Hs/AcPRC2 in complex with 5,8-dichloro-2-[(4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-7-[(R)-methoxy(oxetan-3-yl)methyl]-3,4-dihydroisoquinolin-1(2H)-one | 分子名称: | 5,8-dichloro-2-[(4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-7-[(R)-methoxy(oxetan-3-yl)methyl]-3,4-dihydroisoquinolin-1(2H)-one, Enhancer of zeste 2 polycomb repressive complex 2 subunit, Polycomb protein EED, ... | 著者 | Gajiwala, K.S, Brooun, A, Liu, W, Deng, Y, Stewart, A.E. | 登録日 | 2017-09-25 | 公開日 | 2017-12-27 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.81 Å) | 主引用文献 | Optimization of Orally Bioavailable Enhancer of Zeste Homolog 2 (EZH2) Inhibitors Using Ligand and Property-Based Design Strategies: Identification of Development Candidate (R)-5,8-Dichloro-7-(methoxy(oxetan-3-yl)methyl)-2-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3,4-dihydroisoquinolin-1(2H)-one (PF-06821497). J. Med. Chem., 61, 2018
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8A53
| Crystal structure of AtMCA-IIf C147A (metacaspase 9) from Arabidopsis thaliana | 分子名称: | Metacaspase-9, NITRATE ION | 著者 | Sabljic, I, Stael, S, Stahlberg, J, Bozhkov, P. | 登録日 | 2022-06-14 | 公開日 | 2023-05-31 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Structure-function study of a Ca 2+ -independent metacaspase involved in lateral root emergence. Proc.Natl.Acad.Sci.USA, 120, 2023
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2WQ9
| Crystal Structure of RBP4 bound to Oleic Acid | 分子名称: | CHLORIDE ION, GLYCEROL, OLEIC ACID, ... | 著者 | Nanao, M, Mercer, D, Nguyen, L, Buckley, D, Stout, T.J. | 登録日 | 2009-08-14 | 公開日 | 2010-09-01 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Crystal Structure of Rbp4 Bound to Oleic Acid To be Published
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2WQA
| Complex of TTR and RBP4 and Oleic Acid | 分子名称: | OLEIC ACID, RETINOL-BINDING PROTEIN 4, SULFATE ION, ... | 著者 | Nanao, M, Mercer, D, Nguyen, L, Buckley, D, Stout, T.J. | 登録日 | 2009-08-14 | 公開日 | 2010-09-01 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | 主引用文献 | Crystal Structure of Rbp4 Bound to Linoleic Acid and Ttr To be Published
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6M99
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