1BZQ
 
 | | COMPLEX OF A DROMEDARY SINGLE-DOMAIN VHH ANTIBODY FRAGMENT WITH RNASE A | | 分子名称: | PHOSPHATE ION, PROTEIN (ANTIBODY CAB-RN05), PROTEIN (RNASE A) | | 著者 | Decanniere, K, Desmyter, A, Gahroudhi, M, Lauwereys, M, Muyldermans, S, Wyns, L. | | 登録日 | 1998-11-03 | | 公開日 | 1998-11-11 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | A single-domain antibody fragment in complex with RNase A: non-canonical loop structures and nanomolar affinity using two CDR loops.
Structure Fold.Des., 7, 1999
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6FE4
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3G9A
 | | Green fluorescent protein bound to minimizer nanobody | | 分子名称: | Green fluorescent protein, Minimizer | | 著者 | Kirchhofer, A, Helma, J, Schmidthals, K, Frauer, C, Cui, S, Karcher, A, Pellis, M, Muyldermans, S, Delucci, C.C, Cardoso, M.C, Leonhardt, H, Hopfner, K.-P, Rothbauer, U. | | 登録日 | 2009-02-13 | | 公開日 | 2009-12-08 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.614 Å) | | 主引用文献 | Modulation of protein properties in living cells using nanobodies
Nat.Struct.Mol.Biol., 17, 2010
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3K1K
 | | Green fluorescent protein bound to enhancer nanobody | | 分子名称: | Enhancer, Green Fluorescent Protein | | 著者 | Kirchhofer, A, Helma, J, Schmidthals, K, Frauer, C, Cui, S, Karcher, A, Pellis, M, Muyldermans, S, Delucci, C.C, Cardoso, M.C, Leonhardt, H, Hopfner, K.-P, Rothbauer, U. | | 登録日 | 2009-09-28 | | 公開日 | 2009-12-08 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Modulation of protein properties in living cells using nanobodies
Nat.Struct.Mol.Biol., 17, 2010
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4I0C
 | | The structure of the camelid antibody cAbHuL5 in complex with human lysozyme | | 分子名称: | CHLORIDE ION, GLYCEROL, Lysozyme C, ... | | 著者 | De Genst, E, Chan, P.H, Pardon, E, Kumita, J.R, Christodoulou, J, Menzer, L, Chirgadze, D.Y, Robinson, C.V, Muyldermans, S, Matagne, A, Wyns, L, Dobson, C.M, Dumoulin, M. | | 登録日 | 2012-11-16 | | 公開日 | 2013-10-09 | | 最終更新日 | 2013-11-06 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | A nanobody binding to non-amyloidogenic regions of the protein human lysozyme enhances partial unfolding but inhibits amyloid fibril formation.
J.Phys.Chem.B, 117, 2013
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1F2X
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1GHC
 | | HOMO-AND HETERONUCLEAR TWO-DIMENSIONAL NMR STUDIES OF THE GLOBULAR DOMAIN OF HISTONE H1: FULL ASSIGNMENT, TERTIARY STRUCTURE, AND COMPARISON WITH THE GLOBULAR DOMAIN OF HISTONE H5 | | 分子名称: | GH1 | | 著者 | Cerf, C, Lippens, G, Ramakrishnan, V, Muyldermans, S, Segers, A, Wyns, L, Wodak, S.J, Hallenga, K. | | 登録日 | 1994-05-16 | | 公開日 | 1994-08-31 | | 最終更新日 | 2022-02-23 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Homo- and heteronuclear two-dimensional NMR studies of the globular domain of histone H1: full assignment, tertiary structure, and comparison with the globular domain of histone H5.
Biochemistry, 33, 1994
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3EAK
 | | NbBCII10 humanized (FGLA mutant) | | 分子名称: | NbBCII10-FGLA, SULFATE ION | | 著者 | Vincke, C, Loris, R, Saerens, D, Martinez-Rodriguez, S, Muyldermans, S, Conrath, K. | | 登録日 | 2008-08-26 | | 公開日 | 2008-12-02 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | General strategy to humanize a camelid single-domain antibody and identification of a universal humanized nanobody scaffold.
J.Biol.Chem., 2008
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3EBA
 | | CAbHul6 FGLW mutant (humanized) in complex with human lysozyme | | 分子名称: | CAbHul6, Lysozyme C, SULFATE ION | | 著者 | Loris, R, Vincke, C, Saerens, D, Martinez-Rodriguez, S, Muyldermans, S, Conrath, K. | | 登録日 | 2008-08-27 | | 公開日 | 2008-12-02 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | General Strategy to Humanize a Camelid Single-domain Antibody and Identification of a Universal Humanized Nanobody Scaffold
J.Biol.Chem., 284, 2009
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3DWT
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1KXT
 | | Camelid VHH Domains in Complex with Porcine Pancreatic alpha-Amylase | | 分子名称: | ALPHA-AMYLASE, PANCREATIC, CALCIUM ION, ... | | 著者 | Desmyter, A, Spinelli, S, Payan, F, Lauwereys, M, Wyns, L, Muyldermans, S, Cambillau, C. | | 登録日 | 2002-02-01 | | 公開日 | 2002-06-19 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Three camelid VHH domains in complex with porcine pancreatic alpha-amylase. Inhibition and versatility of binding topology.
J.Biol.Chem., 277, 2002
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1KXQ
 | | Camelid VHH Domain in Complex with Porcine Pancreatic alpha-Amylase | | 分子名称: | CALCIUM ION, CHLORIDE ION, alpha-amylase, ... | | 著者 | Desmyter, A, Spinelli, S, Payan, F, Lauwereys, M, Wyns, L, Muyldermans, S, Cambillau, C. | | 登録日 | 2002-02-01 | | 公開日 | 2002-06-19 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Three camelid VHH domains in complex with porcine pancreatic alpha-amylase. Inhibition and versatility of binding topology.
J.Biol.Chem., 277, 2002
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1KXV
 | | Camelid VHH Domains in Complex with Porcine Pancreatic alpha-Amylase | | 分子名称: | ALPHA-AMYLASE, PANCREATIC, CAMELID VHH DOMAIN CAB10 | | 著者 | Desmyter, A, Spinelli, S, Payan, F, Lauwereys, M, Wyns, L, Muyldermans, S, Cambillau, C. | | 登録日 | 2002-02-01 | | 公開日 | 2002-06-19 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Three camelid VHH domains in complex with porcine pancreatic alpha-amylase. Inhibition and versatility of binding topology.
J.Biol.Chem., 277, 2002
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1XFP
 | | Crystal structure of the CDR2 germline reversion mutant of cAb-Lys3 in complex with hen egg white lysozyme | | 分子名称: | FORMIC ACID, Lysozyme C, heavy chain antibody | | 著者 | De Genst, E, Handelberg, F, Van Meirhaeghe, A, Vynck, S, Loris, R, Wyns, L, Muyldermans, S. | | 登録日 | 2004-09-15 | | 公開日 | 2004-09-28 | | 最終更新日 | 2013-02-06 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Chemical Basis for the Affinity Maturation of a Camel Single Domain Antibody
J.Biol.Chem., 279, 2004
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1G6V
 | | Complex of the camelid heavy-chain antibody fragment CAB-CA05 with bovine carbonic anhydrase | | 分子名称: | ANTIBODY HEAVY CHAIN, CARBONIC ANHYDRASE, ZINC ION | | 著者 | Desmyter, A, Decanniere, K, Muyldermans, S, Wyns, L. | | 登録日 | 2000-11-08 | | 公開日 | 2000-11-22 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | | 主引用文献 | Antigen specificity and high affinity binding provided by one single loop of a camel single-domain antibody.
J.Biol.Chem., 276, 2001
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1JTT
 | | Degenerate interfaces in antigen-antibody complexes | | 分子名称: | FORMIC ACID, Lysozyme, SODIUM ION, ... | | 著者 | Decanniere, K, Transue, T.R, Desmyter, A, Maes, D, Muyldermans, S, Wyns, L. | | 登録日 | 2001-08-22 | | 公開日 | 2001-12-05 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Degenerate interfaces in antigen-antibody complexes.
J.Mol.Biol., 313, 2001
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1JTO
 | | Degenerate interfaces in antigen-antibody complexes | | 分子名称: | Lysozyme, Vh Single-Domain Antibody | | 著者 | Decanniere, K, Transue, T.R, Desmyter, A, Maes, D, Muyldermans, S, Wyns, L. | | 登録日 | 2001-08-21 | | 公開日 | 2001-10-31 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Degenerate interfaces in antigen-antibody complexes.
J.Mol.Biol., 313, 2001
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1JTP
 | | Degenerate interfaces in antigen-antibody complexes | | 分子名称: | FORMIC ACID, LYSOZYME C, SODIUM ION, ... | | 著者 | Decanniere, K, Transue, T.R, Desmyter, A, Maes, D, Muyldermans, S, Wyns, L. | | 登録日 | 2001-08-21 | | 公開日 | 2001-12-05 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Degenerate interfaces in antigen-antibody complexes.
J.Mol.Biol., 313, 2001
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1YC8
 | | cAbAn33- Y37V/E44G/R45L triple mutant | | 分子名称: | anti-VSG immunoglobulin heavy chain variable domain cAbAn33 | | 著者 | Conrath, K, Vincke, C, Stijlemans, B, Schymkowitz, J, Wyns, L, Muyldermans, S, Loris, R. | | 登録日 | 2004-12-22 | | 公開日 | 2005-06-14 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Antigen Binding and Solubility Effects upon the Veneering of a Camel VHH in Framework-2 to Mimic a VH.
J.Mol.Biol., 350, 2005
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1YC7
 | | cAbAn33 VHH fragment against VSG | | 分子名称: | SULFATE ION, anti-VSG immunoglobulin heavy chain variable domain cAbAn33 | | 著者 | Conrath, K, Vincke, C, Stijlemans, B, Schymkowitz, J, Wyns, L, Muyldermans, S, Loris, R. | | 登録日 | 2004-12-22 | | 公開日 | 2005-06-14 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Antigen Binding and Solubility Effects upon the Veneering of a Camel VHH in Framework-2 to Mimic a VH.
J.Mol.Biol., 350, 2005
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5LHR
 | | The catalytic domain of murine urokinase-type plasminogen activator in complex with the active site binding inhibitory nanobody Nb22 | | 分子名称: | Camelid-Derived Antibody Fragment Nb22, Urokinase-type plasminogen activator | | 著者 | Kromann-Hansen, T, Lange, E.L, Sorensen, H.P, Ghassabeh, G.H, Huang, M, Jensen, J.K, Muyldermans, S, Declerck, P.J, Andreasen, P.A. | | 登録日 | 2016-07-12 | | 公開日 | 2017-06-28 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Discovery of a novel conformational equilibrium in urokinase-type plasminogen activator.
Sci Rep, 7, 2017
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5LHP
 | | The p-aminobenzamidine active site inhibited catalytic domain of murine urokinase-type plasminogen activator in complex with the allosteric inhibitory nanobody Nb7 | | 分子名称: | 1,2-ETHANEDIOL, Camelid-Derived Antibody Fragment, P-AMINO BENZAMIDINE, ... | | 著者 | Kromann-Hansen, T, Lange, E.L, Sorensen, H.P, Ghassabeh, G.H, Huang, M, Jensen, J.K, Muyldermans, S, Declerck, P.J, Andreasen, P.A. | | 登録日 | 2016-07-12 | | 公開日 | 2017-06-28 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.63 Å) | | 主引用文献 | Discovery of a novel conformational equilibrium in urokinase-type plasminogen activator.
Sci Rep, 7, 2017
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5LHN
 | | The catalytic domain of murine urokinase-type plasminogen activator in complex with the allosteric inhibitory nanobody Nb7 | | 分子名称: | 1,2-ETHANEDIOL, Camelid-Derived Antibody Fragment Nb7, SULFATE ION, ... | | 著者 | Kromann-Hansen, T, Lange, E.L, Sorensen, H.P, Ghassabeh, G.H, Huang, M, Jensen, J.K, Muyldermans, S, Declerck, P, Andreasen, P.A. | | 登録日 | 2016-07-12 | | 公開日 | 2017-06-28 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | | 主引用文献 | Discovery of a novel conformational equilibrium in urokinase-type plasminogen activator.
Sci Rep, 7, 2017
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5LHQ
 | | The EGR-cmk active site inhibited catalytic domain of murine urokinase-type plasminogen activator in complex with the allosteric inhibitory nanobody Nb7 | | 分子名称: | 1,2-ETHANEDIOL, Camelid-Derived Antibody Fragment Nb7, L-alpha-glutamyl-N-{(1S)-4-{[amino(iminio)methyl]amino}-1-[(1S)-2-chloro-1-hydroxyethyl]butyl}glycinamide, ... | | 著者 | Kromann-Hansen, T, Lange, E.L, Sorensen, H.P, Ghassabeh, G.H, Huang, M, Jensen, J.K, Muyldermans, S, Declerck, P.J, Andreasen, P.A. | | 登録日 | 2016-07-12 | | 公開日 | 2017-06-28 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Discovery of a novel conformational equilibrium in urokinase-type plasminogen activator.
Sci Rep, 7, 2017
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5LHS
 | | The ligand free catalytic domain of murine urokinase-type plasminogen activator | | 分子名称: | NICKEL (II) ION, SULFATE ION, Urokinase-type plasminogen activator | | 著者 | Kromann-Hansen, T, Lange, E.L, Sorensen, H.P, Ghassabeh, G.H, Huang, M, Jensen, J.K, Muyldermans, S, Declerck, P.J, Andreasen, P.A. | | 登録日 | 2016-07-12 | | 公開日 | 2017-06-28 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (3.047 Å) | | 主引用文献 | Discovery of a novel conformational equilibrium in urokinase-type plasminogen activator.
Sci Rep, 7, 2017
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