3EBA

CAbHul6 FGLW mutant (humanized) in complex with human lysozyme

Summary for 3EBA

Related1op9
DescriptorCAbHul6, Lysozyme C, SULFATE ION, ... (4 entities in total)
Functional Keywordsantigen-antibody complex, immunoglobulin, nanobody, humanization, amyloid fibril formation inhibition, amyloid, antimicrobial, bacteriolytic enzyme, disease mutation, glycosidase, hydrolase, polymorphism, immune system-hydrolase complex, immune system/hydrolase
Biological sourceCamelus dromedarius
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Cellular locationSecreted P61626
Total number of polymer chains2
Total molecular weight29148.28
Authors
Loris, R.,Vincke, C.,Saerens, D.,Martinez-Rodriguez, S.,Muyldermans, S.,Conrath, K. (deposition date: 2008-08-27, release date: 2008-12-02, Last modification date: 2011-07-13)
Primary citation
Vincke, C.,Loris, R.,Saerens, D.,Martinez-Rodriguez, S.,Muyldermans, S.,Conrath, K.
General Strategy to Humanize a Camelid Single-domain Antibody and Identification of a Universal Humanized Nanobody Scaffold
J.Biol.Chem., 284:3273-3284, 2009
PubMed: 19010777 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M806889200
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.85 Å)
NMR Information
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.25090.4%1.6%8.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 3eba
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Molmil generated image of 3eba
rotated about x axis by 90°
Molmil generated image of 3eba
rotated about y axis by 90°