6BO8
 
 | | Cryo-EM structure of human TRPV6 in nanodiscs | | Descriptor: | Transient receptor potential cation channel subfamily V member 6 | | Authors: | McGoldrick, L.L, Singh, A.K, Saotome, K, Yelshanskaya, M.V, Twomey, E.C, Grassucci, R.A, Sobolevsky, A.I. | | Deposit date: | 2017-11-18 | | Release date: | 2017-12-20 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Opening of the human epithelial calcium channel TRPV6.
Nature, 553, 2018
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6BOB
 | | Cryo-EM structure of rat TRPV6* in nanodiscs | | Descriptor: | Transient receptor potential cation channel subfamily V member 6 | | Authors: | McGoldrick, L.L, Singh, A.K, Saotome, K, Yelshanskaya, M.V, Twomey, E.C, Grassucci, R.A, Sobolevsky, A.I. | | Deposit date: | 2017-11-18 | | Release date: | 2017-12-20 | | Last modified: | 2025-05-28 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Opening of the human epithelial calcium channel TRPV6.
Nature, 553, 2018
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6BO9
 | | Cryo-EM structure of human TRPV6 in amphipols | | Descriptor: | Transient receptor potential cation channel subfamily V member 6 | | Authors: | McGoldrick, L.L, Singh, A.K, Saotome, K, Yelshanskaya, M.V, Twomey, E.C, Grassucci, R.A, Sobolevsky, A.I. | | Deposit date: | 2017-11-18 | | Release date: | 2017-12-20 | | Last modified: | 2025-05-28 | | Method: | ELECTRON MICROSCOPY (4 Å) | | Cite: | Opening of the human epithelial calcium channel TRPV6.
Nature, 553, 2018
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6PW5
 | | Cryo-EM Structure of Thermo-Sensitive TRP Channel TRP1 from the Alga Chlamydomonas reinhardtii in Nanodiscs | | Descriptor: | (2S)-3-{[(R)-hydroxy{[(1R,2R,3S,4R,5R,6S)-2,3,6-trihydroxy-4,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dihexadecanoate, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, TRP-like ion channel, ... | | Authors: | McGoldrick, L.L, Singh, A.K, Sobolevsky, A.I. | | Deposit date: | 2019-07-22 | | Release date: | 2019-09-25 | | Last modified: | 2024-11-20 | | Method: | ELECTRON MICROSCOPY (3.45 Å) | | Cite: | Structure of the thermo-sensitive TRP channel TRP1 from the alga Chlamydomonas reinhardtii.
Nat Commun, 10, 2019
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6PW4
 | | Cryo-EM Structure of Thermo-Sensitive TRP Channel TRP1 from the Alga Chlamydomonas reinhardtii in Detergent | | Descriptor: | (2S)-3-{[(R)-hydroxy{[(1R,2R,3S,4R,5R,6S)-2,3,6-trihydroxy-4,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dihexadecanoate, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... | | Authors: | McGoldrick, L.L, Singh, A.K, Sobolevsky, A.I. | | Deposit date: | 2019-07-22 | | Release date: | 2019-09-25 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (3.53 Å) | | Cite: | Structure of the thermo-sensitive TRP channel TRP1 from the alga Chlamydomonas reinhardtii.
Nat Commun, 10, 2019
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6BOA
 | | Cryo-EM structure of human TRPV6-R470E in amphipols | | Descriptor: | Transient receptor potential cation channel subfamily V member 6 | | Authors: | McGoldrick, L.L, Singh, A.K, Saotome, K, Yelshanskaya, M.V, Twomey, E.C, Grassucci, R.A, Sobolevsky, A.I. | | Deposit date: | 2017-11-18 | | Release date: | 2017-12-20 | | Last modified: | 2025-05-28 | | Method: | ELECTRON MICROSCOPY (4.2 Å) | | Cite: | Opening of the human epithelial calcium channel TRPV6.
Nature, 553, 2018
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6MP4
 | | Human liver FABP1 bound to tetrahydrocannabinol | | Descriptor: | (6aR,10aR)-6,6,9-trimethyl-3-pentyl-6a,7,8,10a-tetrahydro-6H-benzo[c]chromen-1-ol, Fatty acid-binding protein, liver, ... | | Authors: | McGoldrick, L.L, Giuliano, C.J, Elmes, M.W, Deutsch, D.G, Kaczocha, M, Glynn, S.E. | | Deposit date: | 2018-10-05 | | Release date: | 2019-11-13 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.502 Å) | | Cite: | FABP1 controls hepatic transport and biotransformation of Delta 9 -THC.
Sci Rep, 9, 2019
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8U4N
 | | Structure of Apo CXCR4/Gi complex | | Descriptor: | C-X-C chemokine receptor type 4, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Saotome, K, McGoldrick, L.L, Franklin, M.C. | | Deposit date: | 2023-09-11 | | Release date: | 2024-03-13 | | Last modified: | 2025-02-26 | | Method: | ELECTRON MICROSCOPY (2.72 Å) | | Cite: | Structural insights into CXCR4 modulation and oligomerization.
Nat.Struct.Mol.Biol., 32, 2025
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8U4R
 | | Structure of REGN7663-Fab bound CXCR4 | | Descriptor: | C-X-C chemokine receptor type 4, CHOLESTEROL, REGN7663 Fab heavy chain, ... | | Authors: | Saotome, K, McGoldrick, L.L, Franklin, M.C. | | Deposit date: | 2023-09-11 | | Release date: | 2024-03-13 | | Last modified: | 2025-02-26 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structural insights into CXCR4 modulation and oligomerization.
Nat.Struct.Mol.Biol., 32, 2025
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8U4T
 | | Structure of tetrameric CXCR4 in complex with REGN7663 Fab | | Descriptor: | (2R)-1-(hexadecanoyloxy)-3-(phosphonooxy)propan-2-yl (9Z)-octadec-9-enoate, C-X-C chemokine receptor type 4, CHOLESTEROL, ... | | Authors: | Saotome, K, McGoldrick, L.L, Franklin, M.C. | | Deposit date: | 2023-09-11 | | Release date: | 2024-03-13 | | Last modified: | 2025-02-26 | | Method: | ELECTRON MICROSCOPY (3.38 Å) | | Cite: | Structural insights into CXCR4 modulation and oligomerization.
Nat.Struct.Mol.Biol., 32, 2025
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8U4P
 | | Structure of AMD3100-bound CXCR4/Gi complex | | Descriptor: | C-X-C chemokine receptor type 4, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Saotome, K, McGoldrick, L.L, Franklin, M.C. | | Deposit date: | 2023-09-11 | | Release date: | 2024-03-13 | | Last modified: | 2025-02-26 | | Method: | ELECTRON MICROSCOPY (3.15 Å) | | Cite: | Structural insights into CXCR4 modulation and oligomerization.
Nat.Struct.Mol.Biol., 32, 2025
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8U4O
 | | Structure of CXCL12-bound CXCR4/Gi complex | | Descriptor: | C-X-C chemokine receptor type 4, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Saotome, K, McGoldrick, L.L, Franklin, M.C. | | Deposit date: | 2023-09-11 | | Release date: | 2024-03-13 | | Last modified: | 2025-02-26 | | Method: | ELECTRON MICROSCOPY (3.29 Å) | | Cite: | Structural insights into CXCR4 modulation and oligomerization.
Nat.Struct.Mol.Biol., 32, 2025
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8U4S
 | | Structure of trimeric CXCR4 in complex with REGN7663 Fab | | Descriptor: | (2R)-1-(hexadecanoyloxy)-3-(phosphonooxy)propan-2-yl (9Z)-octadec-9-enoate, C-X-C chemokine receptor type 4, CHOLESTEROL, ... | | Authors: | Saotome, K, McGoldrick, L.L, Franklin, M.C. | | Deposit date: | 2023-09-11 | | Release date: | 2024-03-13 | | Last modified: | 2025-02-26 | | Method: | ELECTRON MICROSCOPY (3.35 Å) | | Cite: | Structural insights into CXCR4 modulation and oligomerization.
Nat.Struct.Mol.Biol., 32, 2025
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8U4Q
 | | Structure of REGN7663 Fab-bound CXCR4/Gi complex | | Descriptor: | C-X-C chemokine receptor type 4, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Saotome, K, McGoldrick, L.L, Franklin, M.C. | | Deposit date: | 2023-09-11 | | Release date: | 2024-03-13 | | Last modified: | 2025-02-26 | | Method: | ELECTRON MICROSCOPY (3.36 Å) | | Cite: | Structural insights into CXCR4 modulation and oligomerization.
Nat.Struct.Mol.Biol., 32, 2025
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6PVQ
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6PVN
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6PVM
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6PVL
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6PVO
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6PVP
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6D7S
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6D7Q
 | | Crystal Structure of Rat TRPV6*-Y466A in complex with 2-Aminoethoxydiphenyl borate (2-APB) | | Descriptor: | 2-aminoethyl diphenylborinate, 6-(5-METHYL-2-OXO-IMIDAZOLIDIN-4-YL)-HEXANOIC ACID, CALCIUM ION, ... | | Authors: | Singh, A.K, Saotome, K, McGoldrick, L.L, Sobolevsky, A.I. | | Deposit date: | 2018-04-25 | | Release date: | 2018-07-18 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (3.497 Å) | | Cite: | Structural bases of TRP channel TRPV6 allosteric modulation by 2-APB.
Nat Commun, 9, 2018
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6D7X
 | | Crystal Structure of Rat TRPV6*-Y466A- in complex with brominated 2-Aminoethoxydiphenyl borate (2-APB-Br) | | Descriptor: | 2-aminoethyl (4-bromophenyl)phenylborinate, 6-(5-METHYL-2-OXO-IMIDAZOLIDIN-4-YL)-HEXANOIC ACID, CALCIUM ION, ... | | Authors: | Singh, A.K, Saotome, K, McGoldrick, L.L, Sobolevsky, A.I. | | Deposit date: | 2018-04-25 | | Release date: | 2018-07-18 | | Last modified: | 2024-12-25 | | Method: | X-RAY DIFFRACTION (3.6 Å) | | Cite: | Structural bases of TRP channel TRPV6 allosteric modulation by 2-APB.
Nat Commun, 9, 2018
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6DVZ
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6D7O
 | | Crystal Structure of Rat TRPV6* in complex with 2-Aminoethoxydiphenyl borate (2-APB) | | Descriptor: | 2-aminoethyl diphenylborinate, 6-(5-METHYL-2-OXO-IMIDAZOLIDIN-4-YL)-HEXANOIC ACID, CALCIUM ION, ... | | Authors: | Singh, A.K, Saotome, K, McGoldrick, L.L, Sobolevsky, A.I. | | Deposit date: | 2018-04-25 | | Release date: | 2018-07-18 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (3.45 Å) | | Cite: | Structural bases of TRP channel TRPV6 allosteric modulation by 2-APB.
Nat Commun, 9, 2018
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