6PVL

Cryo-EM structure of mouse TRPV3 in closed state at 42 degrees Celsius

Summary for 6PVL

Entry DOI	10.2210/pdb6pvl/pdb
EMDB information	20492 20493 20494 20495 20496 20497
Descriptor	Transient receptor potential cation channel subfamily V member 3, SODIUM ION (2 entities in total)
Functional Keywords	ion channels, membrane protein, trp channels, transport protein
Biological source	Mus musculus (Mouse)
Total number of polymer chains	4
Total formula weight	370568.76
Authors	Singh, A.K.,McGoldrick, L.L.,Sobolevsky, A.I. (deposition date: 2019-07-21, release date: 2019-10-23, Last modification date: 2024-03-20)
Primary citation	Singh, A.K.,McGoldrick, L.L.,Demirkhanyan, L.,Leslie, M.,Zakharian, E.,Sobolevsky, A.I. Structural basis of temperature sensation by the TRP channel TRPV3. Nat.Struct.Mol.Biol., 26:994-998, 2019 Cited by PubMed Abstract: We present structures of mouse TRPV3 in temperature-dependent open, closed and intermediate states that suggest two-step activation of TRPV3 by heat. During the strongly temperature-dependent first step, sensitization, the channel pore remains closed while S6 helices undergo α-to-π transitions. During the weakly temperature-dependent second step, channel opening, tight association of the S1-S4 and pore domains is stabilized by changes in the carboxy-terminal and linker domains. PubMed: 31636415 DOI: 10.1038/s41594-019-0318-7 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (4.4 Å)

Structure validation