1S4G
| Somatomedin-B Domain of human plasma vitronectin. | 分子名称: | HYDROXIDE ION, Vitronectin | 著者 | Mayasundari, A, Whittemore, N.A, Serpersu, E.H, Peterson, C.B. | 登録日 | 2004-01-16 | 公開日 | 2004-06-08 | 最終更新日 | 2022-03-02 | 実験手法 | SOLUTION NMR | 主引用文献 | The solution structure of the N-terminal domain of human vitronectin: proximal sites that regulate fibrinolysis and cell migration J.Biol.Chem., 279, 2004
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2JQ8
| Solution structure of the Somatomedin B domain from vitronectin produced in Pichia pastoris | 分子名称: | Vitronectin | 著者 | Gaardsvoll, H, Hirschberg, D, Nielbo, S, Mayasundari, A, Peterson, C.B, Jansson, A, Jorgensen, T.J.D, Poulsen, F.M. | 登録日 | 2007-05-30 | 公開日 | 2007-09-11 | 最終更新日 | 2023-12-20 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure of recombinant somatomedin B domain from vitronectin produced in Pichia pastoris Protein Sci., 16, 2007
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7SHH
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7RMD
| Crystal structure of the first bromodomain of human BRD4 in complex with SJ001011461-1 | 分子名称: | 1,2-ETHANEDIOL, 2-[(6S,10R)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]-N-(1,3,4-thiadiazol-2-yl)acetamide, Bromodomain-containing protein 4 | 著者 | Stachowski, T.R, Fischer, M. | 登録日 | 2021-07-27 | 公開日 | 2022-08-03 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.18 Å) | 主引用文献 | From PROTAC to inhibitor: Structure-guided discovery of potent and orally bioavailable BET inhibitors. Eur.J.Med.Chem., 251, 2023
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7RN2
| Crystal structure of the first bromodomain of human BRD4 in complex with SJ001010551-2 | 分子名称: | 1,2-ETHANEDIOL, 2-[(6S,10S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]-N-[(pyridin-2-yl)methyl]acetamide, Bromodomain-containing protein 4 | 著者 | Stachowski, T.R, Fischer, M. | 登録日 | 2021-07-28 | 公開日 | 2022-08-03 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.05 Å) | 主引用文献 | From PROTAC to inhibitor: Structure-guided discovery of potent and orally bioavailable BET inhibitors. Eur.J.Med.Chem., 251, 2023
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6WTQ
| Human JAK2 JH1 domain in complex with PROTAC-intermediate linker handle 4 | 分子名称: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, N-methyl-4-{[4-(1-propyl-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino}benzamide, ... | 著者 | Yu, S, Nithianantham, S, Fischer, M. | 登録日 | 2020-05-03 | 公開日 | 2021-05-05 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.79968476 Å) | 主引用文献 | Degradation of Janus kinases in CRLF2-rearranged acute lymphoblastic leukemia. Blood, 138, 2021
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6WTN
| Human JAK2 JH1 domain in complex with Ruxolitinib | 分子名称: | (3R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile, 1,2-ETHANEDIOL, Tyrosine-protein kinase JAK2 | 著者 | Yu, S, Nithianantham, S, Fischer, M. | 登録日 | 2020-05-03 | 公開日 | 2021-05-05 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.83 Å) | 主引用文献 | Degradation of Janus kinases in CRLF2-rearranged acute lymphoblastic leukemia. Blood, 138, 2021
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6WTP
| Human JAK2 JH1 domain in complex with PROTAC-intermediate linker handle 3 | 分子名称: | GLYCEROL, Tyrosine-protein kinase JAK2, tert-butyl 4-[(4-{1-[3-(cyanomethyl)-1-(ethylsulfonyl)azetidin-3-yl]-1H-pyrazol-4-yl}-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino]benzoate | 著者 | Yu, S, Nithianantham, S, Fischer, M. | 登録日 | 2020-05-03 | 公開日 | 2021-05-05 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Degradation of Janus kinases in CRLF2-rearranged acute lymphoblastic leukemia. Blood, 138, 2021
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6WTO
| Human JAK2 JH1 domain in complex with Baricitinib | 分子名称: | 1,2-ETHANEDIOL, Baricitinib, Tyrosine-protein kinase JAK2 | 著者 | Yu, S, Nithianantham, S, Fischer, M. | 登録日 | 2020-05-03 | 公開日 | 2021-05-05 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.74 Å) | 主引用文献 | Degradation of Janus kinases in CRLF2-rearranged acute lymphoblastic leukemia. Blood, 138, 2021
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6WWB
| Crystal Structure of the second bromodomain of human BRD2 in complex with the compound 3b | 分子名称: | 1,2-ETHANEDIOL, 2-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-((1-(4-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)acetamido)butyl)-1H-1,2,3-triazol-4-yl)methyl)acetamide, Bromodomain-containing protein 2 | 著者 | White, S.W, Yun, M. | 登録日 | 2020-05-08 | 公開日 | 2021-11-17 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.31 Å) | 主引用文献 | Phenyl-Glutarimides: Alternative Cereblon Binders for the Design of PROTACs. Angew.Chem.Int.Ed.Engl., 60, 2021
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6WJH
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2N0W
| Mdmx-SJ212 | 分子名称: | 4-({(4S,5R)-4-(5-bromo-2-fluorophenyl)-5-(4-chlorophenyl)-2-[4-methoxy-2-(propan-2-yloxy)phenyl]-4,5-dihydro-1H-imidazol-1-yl}carbonyl)piperazin-2-one, Protein Mdm4 | 著者 | Grace, C.R, Kriwacki, R.W. | 登録日 | 2015-03-17 | 公開日 | 2016-01-27 | 最終更新日 | 2016-05-04 | 実験手法 | SOLUTION NMR | 主引用文献 | Monitoring Ligand-Induced Protein Ordering in Drug Discovery. J.Mol.Biol., 428, 2016
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2N06
| Mdmx-298 | 分子名称: | 4-[[(4S,5R)-5-(4-chlorophenyl)-4-(3-methoxyphenyl)-2-(4-methoxy-2-propan-2-yloxy-phenyl)-4,5-dihydroimidazol-1-yl]carbonyl]piperazin-2-one, Protein Mdm4 | 著者 | Grace, C.R, Kriwacki, R.W. | 登録日 | 2015-03-04 | 公開日 | 2016-01-27 | 最終更新日 | 2019-11-06 | 実験手法 | SOLUTION NMR | 主引用文献 | Monitoring Ligand-Induced Protein Ordering in Drug Discovery. J.Mol.Biol., 428, 2016
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2N14
| Mdmx-295 | 分子名称: | 4-({(4S,5R)-4-(3-chlorophenyl)-5-(4-chlorophenyl)-2-[4-methoxy-2-(propan-2-yloxy)phenyl]-4,5-dihydro-1H-imidazol-1-yl}carbonyl)piperazin-2-one, Protein Mdm4 | 著者 | Grace, C.R, Kriwacki, R.W. | 登録日 | 2015-03-20 | 公開日 | 2016-01-27 | 最終更新日 | 2016-05-04 | 実験手法 | SOLUTION NMR | 主引用文献 | Monitoring Ligand-Induced Protein Ordering in Drug Discovery. J.Mol.Biol., 428, 2016
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2N0U
| Mdmx-057 | 分子名称: | 4-[(4S,5R)-4-(3-chlorophenyl)-5-(4-chlorophenyl)-1-(3-oxidanylidenepiperazin-1-yl)carbonyl-4,5-dihydroimidazol-2-yl]-3-propan-2-yloxy-benzenecarbonitrile, Protein Mdm4 | 著者 | Grace, C.R, Kriwacki, R.W. | 登録日 | 2015-03-17 | 公開日 | 2016-01-27 | 最終更新日 | 2016-05-04 | 実験手法 | SOLUTION NMR | 主引用文献 | Monitoring Ligand-Induced Protein Ordering in Drug Discovery. J.Mol.Biol., 428, 2016
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2MWY
| Mdmx-p53 | 分子名称: | Cellular tumor antigen p53, Protein Mdm4 | 著者 | Grace, C.R. | 登録日 | 2014-12-03 | 公開日 | 2016-01-27 | 最終更新日 | 2023-06-14 | 実験手法 | SOLUTION NMR | 主引用文献 | Monitoring Ligand-Induced Protein Ordering in Drug Discovery. J.Mol.Biol., 428, 2016
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