7RN2

Crystal structure of the first bromodomain of human BRD4 in complex with SJ001010551-2

Summary for 7RN2

• Entry DOI: 10.2210/pdb7rn2/pdb
• Descriptor: Bromodomain-containing protein 4, 1,2-ETHANEDIOL, 2-[(6S,10S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]-N-[(pyridin-2-yl)methyl]acetamide, ... (4 entities in total)
• Functional Keywords: bromodomain-containing protein 4 isoform long, brd4, bromodomain containing protein 4, mitotic chromosome associated protein, cell cycle
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 15652.46

Authors

Stachowski, T.R.,Fischer, M. (deposition date: 2021-07-28, release date: 2022-08-03, Last modification date: 2023-10-18)

• Primary citation: Koravovic, M.,Mayasundari, A.,Tasic, G.,Keramatnia, F.,Stachowski, T.R.,Cui, H.,Chai, S.C.,Jonchere, B.,Yang, L.,Li, Y.,Fu, X.,Hiltenbrand, R.,Paul, L.,Mishra, V.,Klco, J.M.,Roussel, M.F.,Pomerantz, W.C.,Fischer, M.,Rankovic, Z.,Savic, V.; From PROTAC to inhibitor: Structure-guided discovery of potent and orally bioavailable BET inhibitors.; Eur.J.Med.Chem., 251:115246-115246, 2023; PubMed: 36898329; DOI: 10.1016/j.ejmech.2023.115246

Experimental method

X-RAY DIFFRACTION (1.05 Å)