7SHH

Bacterial cereblon homologue in complex with (R)-3-(4-methoxyphenyl)piperidine-2,6-dione

Summary for 7SHH

Entry DOI	10.2210/pdb7shh/pdb
Descriptor	Cereblon isoform 4, ZINC ION, (3R)-3-(4-methoxyphenyl)piperidine-2,6-dione, ... (4 entities in total)
Functional Keywords	cereblon, protac, targeted protein degradation, tbd, signaling protein
Biological source	Magnetospirillum gryphiswaldense
Total number of polymer chains	3
Total formula weight	41922.59
Authors	Nithianantham, S.,Fischer, M. (deposition date: 2021-10-08, release date: 2022-04-13)
Primary citation	Alcock, L.J.,Chang, Y.,Jarusiewicz, J.A.,Actis, M.,Nithianantham, S.,Mayasundari, A.,Min, J.,Maxwell, D.,Hunt, J.,Smart, B.,Yang, J.J.,Nishiguchi, G.,Fischer, M.,Mullighan, C.G.,Rankovic, Z. Development of Potent and Selective Janus Kinase 2/3 Directing PG-PROTACs. Acs Med.Chem.Lett., 13:475-482, 2022 Cited by PubMed: 35300081 DOI: 10.1021/acsmedchemlett.1c00650 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation