6WTO

Human JAK2 JH1 domain in complex with Baricitinib

Summary for 6WTO

Entry DOI	10.2210/pdb6wto/pdb
Descriptor	Tyrosine-protein kinase JAK2, 1,2-ETHANEDIOL, Baricitinib, ... (4 entities in total)
Functional Keywords	phosphorylation, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	36907.85
Authors	Yu, S.,Nithianantham, S.,Fischer, M. (deposition date: 2020-05-03, release date: 2021-05-05, Last modification date: 2023-11-15)
Primary citation	Chang, Y.,Min, J.,Jarusiewicz, J.A.,Actis, M.,Yu-Chen Bradford, S.,Mayasundari, A.,Yang, L.,Chepyala, D.,Alcock, L.J.,Roberts, K.G.,Nithianantham, S.,Maxwell, D.,Rowland, L.,Larsen, R.,Seth, A.,Goto, H.,Imamura, T.,Akahane, K.,Hansen, B.S.,Pruett-Miller, S.M.,Paietta, E.M.,Litzow, M.R.,Qu, C.,Yang, J.J.,Fischer, M.,Rankovic, Z.,Mullighan, C.G. Degradation of Janus kinases in CRLF2-rearranged acute lymphoblastic leukemia. Blood, 138:2313-2326, 2021 Cited by PubMed: 34110416 DOI: 10.1182/blood.2020006846 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.74 Å)

Structure validation