6WTQ

Human JAK2 JH1 domain in complex with PROTAC-intermediate linker handle 4

Summary for 6WTQ

• Entry DOI: 10.2210/pdb6wtq/pdb
• Descriptor: Tyrosine-protein kinase JAK2, N-methyl-4-{[4-(1-propyl-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino}benzamide, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... (5 entities in total)
• Functional Keywords: phosphorylation, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 36971.93

Authors

Yu, S.,Nithianantham, S.,Fischer, M. (deposition date: 2020-05-03, release date: 2021-05-05, Last modification date: 2023-11-15)

• Primary citation: Chang, Y.,Min, J.,Jarusiewicz, J.A.,Actis, M.,Yu-Chen Bradford, S.,Mayasundari, A.,Yang, L.,Chepyala, D.,Alcock, L.J.,Roberts, K.G.,Nithianantham, S.,Maxwell, D.,Rowland, L.,Larsen, R.,Seth, A.,Goto, H.,Imamura, T.,Akahane, K.,Hansen, B.S.,Pruett-Miller, S.M.,Paietta, E.M.,Litzow, M.R.,Qu, C.,Yang, J.J.,Fischer, M.,Rankovic, Z.,Mullighan, C.G.; Degradation of Janus kinases in CRLF2-rearranged acute lymphoblastic leukemia.; Blood, 138:2313-2326, 2021; PubMed: 34110416; DOI: 10.1182/blood.2020006846

Experimental method

X-RAY DIFFRACTION (1.79968475557 Å)