6WTQ
Human JAK2 JH1 domain in complex with PROTAC-intermediate linker handle 4
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Tyrosine-protein kinase JAK2 | polymer | 309 | 36412.3 | 1 | UniProt (O60674) Pfam (PF07714) | Homo sapiens (Human) | Janus kinase 2,JAK-2 |
| 2 | B (A) | N-methyl-4-{[4-(1-propyl-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino}benzamide | non-polymer | 375.4 | 1 | Chemie (U8J) | |||
| 3 | C (A) | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | non-polymer | 122.1 | 1 | Chemie (TRS) | |||
| 4 | D (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 5 | E (A) | water | water | 18.0 | 60 | Chemie (HOH) |
Sequence modifications
A: 835 - 1132 (UniProt: O60674)
| PDB | External Database | Details |
|---|---|---|
| Met 834 | - | initiating methionine |
| Gly 1133 | - | expression tag |
| Ser 1134 | - | expression tag |
| Gly 1135 | - | expression tag |
| Ser 1136 | - | expression tag |
| Glu 1137 | - | expression tag |
| Asn 1138 | - | expression tag |
| Leu 1139 | - | expression tag |
| Tyr 1140 | - | expression tag |
| Phe 1141 | - | expression tag |
| Gln 1142 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 36412.3 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 559.6 | |
| All* | Total formula weight | 36971.9 |
