7O17
 
 | | ABC transporter NosDFY E154Q, ATP-bound in lipid nanodisc | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Probable ABC transporter ATP-binding protein NosF, ... | | 著者 | Mueller, C, Zhang, L, Lu, W, Einsle, O, Du, J. | | 登録日 | 2021-03-28 | | 公開日 | 2022-04-13 | | 最終更新日 | 2022-10-26 | | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | | 主引用文献 | Molecular interplay of an assembly machinery for nitrous oxide reductase.
Nature, 608, 2022
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4E9B
 | | Structure of Peptide Deformylase form Helicobacter Pylori in complex with actinonin | | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ACTINONIN, COBALT (II) ION, ... | | 著者 | Cui, K, Zhu, L, Lu, W, Huang, J. | | 登録日 | 2012-03-20 | | 公開日 | 2013-04-24 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Identification of Novel Peptide Deformylase Inhibitors from Natural Products
To be Published
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2PM1
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2PM4
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2PLZ
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4R7L
 | | Structure of Human Leukotriene A4 Hydrolase in complex with inhibitor H1 | | 分子名称: | ACETATE ION, GLYCEROL, IMIDAZOLE, ... | | 著者 | Ouyang, P, Cui, K, Lu, W, Huang, J. | | 登録日 | 2014-08-27 | | 公開日 | 2015-11-25 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (1.66 Å) | | 主引用文献 | Human Leukotriene A4 Hydrolase in complex with SAHA
To be Published
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8SR8
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8SR9
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8SRA
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8SRB
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8SR7
 | | Cryo-EM structure of TRPM2 chanzyme in the presence of Magnesium, Adenosine monophosphate, and Ribose-5-phosphate | | 分子名称: | 5-O-phosphono-beta-D-ribofuranose, ADENOSINE MONOPHOSPHATE, CHOLESTEROL, ... | | 著者 | Huang, Y, Kumar, S, Lu, W, Du, J. | | 登録日 | 2023-05-05 | | 公開日 | 2024-05-08 | | 実験手法 | ELECTRON MICROSCOPY (1.97 Å) | | 主引用文献 | Coupling enzymatic activity and gating in an ancient TRPM chanzyme and its molecular evolution
To Be Published
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8SRC
 | | Cryo-EM structure of TRPM2 chanzyme in the presence of Calcium and ADP-ribose | | 分子名称: | ADENOSINE-5-DIPHOSPHORIBOSE, CALCIUM ION, CHOLESTEROL, ... | | 著者 | Huang, Y, Kumar, S, Lu, W, Du, J. | | 登録日 | 2023-05-05 | | 公開日 | 2024-05-08 | | 実験手法 | ELECTRON MICROSCOPY (2.92 Å) | | 主引用文献 | Coupling enzymatic activity and gating in an ancient TRPM chanzyme and its molecular evolution
To Be Published
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2ZJK
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2ZJL
 | | Crystal structure of the human BACE1 catalytic domain in complex with N-[1-(5-bromo-2,3-dimethoxy-benzyl)-piperidin-4-yl]-4-mercapto-butyramide | | 分子名称: | Beta-secretase 1, N-[1-(5-bromo-2,3-dimethoxybenzyl)piperidin-4-yl]-4-sulfanylbutanamide | | 著者 | Randal, M, Lam, M.B, Lu, W, Romanowski, M.J. | | 登録日 | 2008-03-07 | | 公開日 | 2009-01-20 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Fragment-based discovery of novel BACE1 inhibitors using Tethering technology
To be Published
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6PUO
 | | Human TRPM2 in the apo state | | 分子名称: | Transient receptor potential cation channel subfamily M member 2 | | 著者 | Du, J, Lu, W, Huang, Y. | | 登録日 | 2019-07-18 | | 公開日 | 2019-09-25 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Ligand recognition and gating mechanism through three ligand-binding sites of human TRPM2 channel.
Elife, 8, 2019
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6PXD
 | | CryoEM structure of zebra fish alpha-1 glycine receptor, Apo state | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Glycine receptor subunit alphaZ1 | | 著者 | Du, J, Lu, W, Gouaux, E. | | 登録日 | 2019-07-25 | | 公開日 | 2021-02-10 | | 最終更新日 | 2022-08-24 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Mechanism of gating and partial agonist action in the glycine receptor.
Cell, 184, 2021
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3H6C
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3HJ2
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3IWY
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3HJD
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2FDP
 | | Crystal structure of beta-secretase complexed with an amino-ethylene inhibitor | | 分子名称: | Beta-secretase 1, N1-((2S,3S,5R)-3-AMINO-6-(4-FLUOROPHENYLAMINO)-5-METHYL-6-OXO-1-PHENYLHEXAN-2-YL)-N3,N3-DIPROPYLISOPHTHALAMIDE | | 著者 | Yang, W, Lu, W, Lu, Y, Zhong, M, Sun, J, Thomas, A.E, Wilkinson, J.M, Fucini, R.V, Lam, M, Randal, M, Shi, X.P, Jacobs, J.W, McDowell, R.S, Gordon, E.M, Ballinger, M.D. | | 登録日 | 2005-12-14 | | 公開日 | 2006-01-24 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Aminoethylenes: a tetrahedral intermediate isostere yielding potent inhibitors of the aspartyl protease BACE-1.
J.Med.Chem., 49, 2006
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1ZMH
 | | Crystal structure of human neutrophil peptide 2, HNP-2 (variant Gly16-> D-Ala) | | 分子名称: | GLYCEROL, HEXAETHYLENE GLYCOL, Neutrophil defensin 2, ... | | 著者 | Lubkowski, J, Prahl, A, Lu, W. | | 登録日 | 2005-05-10 | | 公開日 | 2005-08-16 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Reconstruction of the conserved beta-bulge in mammalian defensins using D-amino acids.
J.Biol.Chem., 280, 2005
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1ZMI
 | | Crystal structure of human alpha_defensin-2 (variant GLY16->D-ALA), P 32 2 1 space group ) | | 分子名称: | GLYCEROL, Neutrophil defensin 2, SULFATE ION | | 著者 | Lubkowski, J, Prahl, A, Lu, W. | | 登録日 | 2005-05-10 | | 公開日 | 2005-08-16 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (1.15 Å) | | 主引用文献 | Reconstruction of the conserved beta-bulge in mammalian defensins using D-amino acids.
J.Biol.Chem., 280, 2005
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1ZMK
 | | Crystal structure of human alpha-defensin-2 (variant Gly16-> D-ALA), P 42 21 2 space group | | 分子名称: | CHLORIDE ION, GLYCEROL, Neutrophil defensin 2 | | 著者 | Lubkowski, J, Prahl, A, Lu, W. | | 登録日 | 2005-05-10 | | 公開日 | 2005-08-16 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | Reconstruction of the conserved beta-bulge in mammalian defensins using D-amino acids.
J.Biol.Chem., 280, 2005
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3LO2
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