4Q25
 
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5HS9
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5HS7
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5HS8
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4XG8
 | | Crystal structure of an inhibitor-bound Syk | | 分子名称: | 1-[(1-{2-[(3-chloro-1-methyl-1H-indazol-5-yl)amino]pyrimidin-4-yl}-3-methyl-1H-pyrazol-4-yl)methyl]azetidin-3-ol, Tyrosine-protein kinase SYK | | 著者 | Lee, S.J, Choi, J, Han, B.G, Song, H, Koh, J.S, Lee, B.I. | | 登録日 | 2014-12-30 | | 公開日 | 2015-12-30 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Crystal structures of spleen tyrosine kinase in complex with novel inhibitors: structural insights for design of anticancer drugs
Febs J., 283, 2016
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4XG2
 | | Crystal structure of ligand-free Syk | | 分子名称: | Tyrosine-protein kinase SYK | | 著者 | Lee, S.J, Choi, J, Han, B.G, Song, H, Koh, J.S, Lee, B.I. | | 登録日 | 2014-12-30 | | 公開日 | 2015-12-30 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.21 Å) | | 主引用文献 | Crystal structures of spleen tyrosine kinase in complex with novel inhibitors: structural insights for design of anticancer drugs
Febs J., 283, 2016
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4XG3
 | | Crystal structure of an inhibitor-bound Syk | | 分子名称: | 4-{[5-fluoro-4-(3-{[(3R)-3-hydroxypyrrolidin-1-yl]methyl}-4-methyl-1H-pyrrol-1-yl)pyrimidin-2-yl]amino}-2,6-dimethylphenyl methanesulfonate, Tyrosine-protein kinase SYK | | 著者 | Lee, S.J, Choi, J, Han, B.G, Song, H, Koh, J.S, Lee, B.I. | | 登録日 | 2014-12-30 | | 公開日 | 2015-12-30 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Crystal structures of spleen tyrosine kinase in complex with novel inhibitors: structural insights for design of anticancer drugs
Febs J., 283, 2016
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4XG7
 | | Crystal structure of an inhibitor-bound Syk | | 分子名称: | 1-[(3-methyl-1-{2-[(1-methyl-1H-indazol-5-yl)amino]pyrimidin-4-yl}-1H-pyrazol-4-yl)methyl]azetidin-3-ol, Tyrosine-protein kinase SYK | | 著者 | Lee, S.J, Choi, J, Han, B.G, Song, H, Koh, J.S, Lee, B.I. | | 登録日 | 2014-12-30 | | 公開日 | 2015-12-30 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | | 主引用文献 | Crystal structures of spleen tyrosine kinase in complex with novel inhibitors: structural insights for design of anticancer drugs
Febs J., 283, 2016
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4XG6
 | | Crystal structure of an inhibitor-bound Syk | | 分子名称: | 1-[(1-{2-[(3,5-dimethylphenyl)amino]pyrimidin-4-yl}-3-methyl-1H-pyrazol-4-yl)methyl]azetidin-3-ol, Tyrosine-protein kinase SYK | | 著者 | Lee, S.J, Choi, J, Han, B.G, Song, H, Koh, J.S, Lee, B.I. | | 登録日 | 2014-12-30 | | 公開日 | 2015-12-30 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Crystal structures of spleen tyrosine kinase in complex with novel inhibitors: structural insights for design of anticancer drugs
Febs J., 283, 2016
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4XG4
 | | Crystal structure of an inhibitor-bound Syk | | 分子名称: | (3R)-1-{[1-(5-fluoro-2-{[4-(2-hydroxyethoxy)-3,5-dimethylphenyl]amino}pyrimidin-4-yl)-4-methyl-1H-pyrrol-3-yl]methyl}pyrrolidin-3-ol, Tyrosine-protein kinase SYK | | 著者 | Lee, S.J, Choi, J, Han, B.G, Song, H, Koh, J.S, Lee, B.I. | | 登録日 | 2014-12-30 | | 公開日 | 2015-12-30 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Crystal structures of spleen tyrosine kinase in complex with novel inhibitors: structural insights for design of anticancer drugs
Febs J., 283, 2016
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4XG9
 | | Crystal structure of an inhibitor-bound Syk | | 分子名称: | 1-[(1-{2-[(3-chloro-1,2-dimethyl-1H-indol-5-yl)amino]pyrimidin-4-yl}-3-methyl-1H-pyrazol-4-yl)methyl]azetidin-3-ol, Tyrosine-protein kinase SYK | | 著者 | Lee, S.J, Choi, J, Han, B.G, Song, H, Koh, J.S, Lee, B.I. | | 登録日 | 2014-12-30 | | 公開日 | 2015-12-30 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.91 Å) | | 主引用文献 | Crystal structures of spleen tyrosine kinase in complex with novel inhibitors: structural insights for design of anticancer drugs
Febs J., 283, 2016
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8K3F
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3U7K
 | | Crystal structures of the Staphylococcus aureus peptide deformylase in complex with two classes of new inhibitors | | 分子名称: | (S)-N-(cyclopentylmethyl)-N-(2-(hydroxyamino)-2-oxoethyl)-2-(3-(2-methoxyphenyl)ureido)-3,3-dimethylbutanamide, Peptide deformylase, ZINC ION | | 著者 | Lee, S.J, Lee, S.-J, Lee, S.K, Yoon, H.-J, Lee, H.H, Kim, K.K, Lee, B.J, Suh, S.W. | | 登録日 | 2011-10-14 | | 公開日 | 2012-06-27 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structures of Staphylococcus aureus peptide deformylase in complex with two classes of new inhibitors
Acta Crystallogr.,Sect.D, 68, 2012
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3U7N
 | | Crystal structures of the Staphylococcus aureus peptide deformylase in complex with two classes of new inhibitors | | 分子名称: | N-((2R,4S)-2-butyl-5-methyl-4-(3-(5-methylpyridin-2-yl)ureido)-3-oxohexyl)-N-hydroxyformamide, Peptide deformylase, ZINC ION | | 著者 | Lee, S.J, Lee, S.-J, Lee, S.K, Yoon, H.-J, Lee, H.H, Kim, K.K, Lee, B.J, Suh, S.W. | | 登録日 | 2011-10-14 | | 公開日 | 2012-06-27 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Structures of Staphylococcus aureus peptide deformylase in complex with two classes of new inhibitors
Acta Crystallogr.,Sect.D, 68, 2012
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3U7L
 | | Crystal structures of the Staphylococcus aureus peptide deformylase in complex with two classes of new inhibitors | | 分子名称: | (S)-N-(cyclopentylmethyl)-2-(3-(3,5-difluorophenyl)ureido)-N-(2-(hydroxyamino)-2-oxoethyl)-3,3-dimethylbutanamide, Peptide deformylase, ZINC ION | | 著者 | Lee, S.J, Lee, S.-J, Lee, S.K, Yoon, H.-J, Lee, H.H, Kim, K.K, Lee, B.J, Suh, S.W. | | 登録日 | 2011-10-14 | | 公開日 | 2012-06-27 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | | 主引用文献 | Structures of Staphylococcus aureus peptide deformylase in complex with two classes of new inhibitors
Acta Crystallogr.,Sect.D, 68, 2012
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3U7M
 | | Crystal structures of the Staphylococcus aureus peptide deformylase in complex with two classes of new inhibitors | | 分子名称: | N-((2R,4S)-2-butyl-4-(3-(2-fluorophenyl)ureido)-5-methyl-3-oxohexyl)-N-hydroxyformamide, Peptide deformylase, ZINC ION | | 著者 | Lee, S.J, Lee, S.-J, Lee, S.K, Yoon, H.-J, Lee, H.H, Kim, K.K, Lee, B.J, Suh, S.W. | | 登録日 | 2011-10-14 | | 公開日 | 2012-06-27 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Structures of Staphylococcus aureus peptide deformylase in complex with two classes of new inhibitors
Acta Crystallogr.,Sect.D, 68, 2012
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4JX7
 | | Crystal structure of Pim1 kinase in complex with inhibitor 2-[(trans-4-aminocyclohexyl)amino]-4-{[3-(trifluoromethyl)phenyl]amino}pyrido[4,3-d]pyrimidin-5(6H)-one | | 分子名称: | 2-[(trans-4-aminocyclohexyl)amino]-4-{[3-(trifluoromethyl)phenyl]amino}pyrido[4,3-d]pyrimidin-5(6H)-one, PIM1 consensus peptide, Serine/threonine-protein kinase pim-1 | | 著者 | Lee, S.J, Han, B.G, Cho, J.W, Choi, J.S, Lee, J.K, Song, H.J, Koh, J.S, Lee, B.I. | | 登録日 | 2013-03-27 | | 公開日 | 2013-08-28 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Crystal structure of pim1 kinase in complex with a pyrido[4,3-d]pyrimidine derivative suggests a unique binding mode.
Plos One, 8, 2013
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4JX3
 | | Crystal structure of Pim1 kinase | | 分子名称: | Serine/threonine-protein kinase pim-1 | | 著者 | Lee, S.J, Han, B.G, Cho, J.W, Choi, J.S, Lee, J.K, Song, H.J, Koh, J.S, Lee, B.I. | | 登録日 | 2013-03-27 | | 公開日 | 2013-08-28 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Crystal structure of pim1 kinase in complex with a pyrido[4,3-d]pyrimidine derivative suggests a unique binding mode.
Plos One, 8, 2013
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5GHV
 | | Crystal structure of an inhibitor-bound Syk | | 分子名称: | 1-({1-[2-({3,5-dimethyl-4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}amino)pyrimidin-4-yl]-4-methyl-1H-pyrrol-3-yl}methyl)azetidin-3-ol, Tyrosine-protein kinase SYK | | 著者 | Lee, S.J, Choi, J, Han, B.G, Song, H, Koh, J.S, Lee, B.I. | | 登録日 | 2016-06-20 | | 公開日 | 2016-07-06 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Crystal structures of spleen tyrosine kinase in complex with novel inhibitors: structural insights for design of anticancer drugs
Febs J., 283, 2016
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4GAM
 | | Complex structure of Methane monooxygenase hydroxylase and regulatory subunit | | 分子名称: | FE (III) ION, Methane monooxygenase component A alpha chain, Methane monooxygenase component A beta chain, ... | | 著者 | Lee, S.J, Lippard, S.J, Cho, U.-S. | | 登録日 | 2012-07-25 | | 公開日 | 2013-02-06 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.902 Å) | | 主引用文献 | Control of substrate access to the active site in methane monooxygenase.
Nature, 494, 2013
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3QHP
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5Y5U
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5Y5T
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7CTC
 | | FECH - inhibitor complex 1 | | 分子名称: | 2-(4-tert-butylphenyl)-5-[(quinolin-2-ylamino)methyl]-6H-[1,2,4]triazolo[1,5-a]pyrimidin-7-one, FE2/S2 (INORGANIC) CLUSTER, Ferrochelatase, ... | | 著者 | Lee, S.J, Park, J. | | 登録日 | 2020-08-18 | | 公開日 | 2021-08-18 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | FECH - inhibitor complex 1
to be published
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7CT7
 | | FECH - inhibitor complex 2 | | 分子名称: | 2-[[(4-chlorophenyl)amino]methyl]-5-propyl-6H-[1,2,4]triazolo[1,5-a]pyrimidin-7-one, FE2/S2 (INORGANIC) CLUSTER, Ferrochelatase, ... | | 著者 | Lee, S.J, Park, J. | | 登録日 | 2020-08-18 | | 公開日 | 2021-08-18 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | FECH - inhibitor complex 1
to be published
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