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7U0M
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BU of 7u0m by Molmil
Crystal structure of a enoyl-[acyl-carrier-protein] reductase (InhA) from Mycobacterium abscessus bound to NAD and NITD-916
Descriptor: 6-[(4,4-dimethylcyclohexyl)methyl]-4-hydroxy-3-phenylpyridin-2(1H)-one, Enoyl-[acyl-carrier-protein] reductase [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ...
Authors:Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2022-02-18
Release date:2022-10-05
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Efficacy and Mode of Action of a Direct Inhibitor of Mycobacterium abscessus InhA.
Acs Infect Dis., 8, 2022
7U0O
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BU of 7u0o by Molmil
Crystal structure of an enoyl-[acyl-carrier-protein] reductase InhA from Mycobacterium fortuitum bound to NAD and NITD-916
Descriptor: 6-[(4,4-dimethylcyclohexyl)methyl]-4-hydroxy-3-phenylpyridin-2(1H)-one, CHLORIDE ION, Enoyl-[acyl-carrier-protein] reductase [NADH], ...
Authors:Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2022-02-18
Release date:2023-02-22
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:In Vitro and In Vivo Efficacy of NITD-916 against Mycobacterium fortuitum.
Antimicrob.Agents Chemother., 67, 2023
2GP6
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BU of 2gp6 by Molmil
X-ray crystal structure of Mycobacterium tuberculosis beta-ketoacyl acyl carrier protein synthase II (mtKasB)
Descriptor: 3-oxoacyl-[acyl-carrier-protein] synthase 2
Authors:Sridharan, S, Sacchettini, J, TB Structural Genomics Consortium (TBSGC)
Deposit date:2006-04-17
Release date:2006-07-18
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:X-Ray Crystal Structure of Mycobacterium tuberculosis beta-Ketoacyl Acyl Carrier Protein Synthase II (mtKasB).
J.Mol.Biol., 366, 2007
7N11
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BU of 7n11 by Molmil
Crystal structure of the M. abscessus LeuRS editing domain in complex with epetraborole-AMP adduct
Descriptor: Leucine--tRNA ligase, SULFATE ION
Authors:Kalthoff, E, Schmeing, M.
Deposit date:2021-05-26
Release date:2021-10-06
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Efficacy of epetraborole against Mycobacterium abscessus is increased with norvaline.
Plos Pathog., 17, 2021
7N12
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BU of 7n12 by Molmil
Crystal structure of the M. abscessus LeuRS editing domain in complex with epetraborole-AMP adduct
Descriptor: Leucine--tRNA ligase, SULFATE ION, [(1S,5R,6R,7'S,8R)-7'-(aminomethyl)-6-(6-aminopurin-9-yl)-2'-(3-oxidanylpropoxy)spiro[2,4,7-trioxa-3-boranuidabicyclo[3.3.0]octane-3,9'-8-oxa-9-boranuidabicyclo[4.3.0]nona-1(6),2,4-triene]-8-yl]methyl dihydrogen phosphate
Authors:Kalthoff, E, Schmeing, M.
Deposit date:2021-05-26
Release date:2021-10-06
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Efficacy of epetraborole against Mycobacterium abscessus is increased with norvaline.
Plos Pathog., 17, 2021
7K73
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BU of 7k73 by Molmil
Structure of Enoyl-[acyl-carrier-protein] reductase [NADH] from Mycobacterium fortuitum bound to NAD
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, Enoyl-[acyl-carrier-protein] reductase [NADH], ...
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2020-09-22
Release date:2020-10-28
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:In Vitro and In Vivo Efficacy of NITD-916 against Mycobacterium fortuitum.
Antimicrob.Agents Chemother., 2023
1M1M
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BU of 1m1m by Molmil
X-RAY CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS BETA-KETOACYL-ACYL CARRIER PROTEIN SYNTHASE III (MTFABH)
Descriptor: 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE III
Authors:Sacchettini, J.C, Sridharan, S, TB Structural Genomics Consortium (TBSGC)
Deposit date:2002-06-19
Release date:2002-07-17
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Probing the mechanism of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III mtFabH: factors influencing catalysis and substrate specificity.
J.Biol.Chem., 280, 2005
5T2U
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BU of 5t2u by Molmil
short chain dehydrogenase/reductase family protein
Descriptor: NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Oxidoreductase, short chain dehydrogenase/reductase family protein
Authors:Mickael, B, Van Wyk, N, Baneres-Roquet, F, Yann, G, Laurent, K.
Deposit date:2016-08-24
Release date:2017-02-15
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Binding of NADP(+) triggers an open-to-closed transition in a mycobacterial FabG beta-ketoacyl-ACP reductase.
Biochem. J., 474, 2017
2LQJ
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BU of 2lqj by Molmil
Solution structure of the C-terminal domain of the MgtC protein from Mycobacterium tuberculosis
Descriptor: Mg2+ transport protein
Authors:Yang, M, Yang, Y, Labesse, G, Blanc-Potard, A.
Deposit date:2012-03-07
Release date:2012-03-21
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:The C-Terminal Domain of the Virulence Factor MgtC Is a Divergent ACT Domain.
J.Bacteriol., 194, 2012
2FEZ
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BU of 2fez by Molmil
Mycobacterium tuberculosis EmbR
Descriptor: Probable regulatory protein embR
Authors:Futterer, K, Alderwick, L.J, Besra, G.S.
Deposit date:2005-12-17
Release date:2006-01-24
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:Molecular structure of EmbR, a response element of Ser/Thr kinase signaling in Mycobacterium tuberculosis
Proc.Natl.Acad.Sci.Usa, 103, 2006
2FF4
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BU of 2ff4 by Molmil
Mycobacterium tuberculosis EmbR in complex with low affinity phosphopeptide
Descriptor: DNA repair protein RAD9, Probable regulatory protein embR
Authors:Futterer, K, Alderwick, L.J, Besra, G.S.
Deposit date:2005-12-19
Release date:2006-01-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Molecular structure of EmbR, a response element of Ser/Thr kinase signaling in Mycobacterium tuberculosis.
Proc.Natl.Acad.Sci.Usa, 103, 2006
7KLI
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BU of 7kli by Molmil
Crystal Structure of Enoyl-[acyl-carrier-protein] reductase [NADH] (InhA) from Mycobacterium abscessus
Descriptor: 1,2-ETHANEDIOL, Enoyl-[acyl-carrier-protein] reductase [NADH], SULFATE ION
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2020-10-30
Release date:2020-11-11
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Efficacy and Mode of Action of a Direct Inhibitor of Mycobacterium abscessus InhA.
Acs Infect Dis., 8, 2022
7L6C
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BU of 7l6c by Molmil
Crystal Structure of Enoyl-[acyl-carrier-protein] reductase InhA from Mycobacterium abscessus in complex with NAD
Descriptor: 1,2-ETHANEDIOL, Enoyl-[acyl-carrier-protein] reductase [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ...
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2020-12-23
Release date:2021-01-13
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Efficacy and Mode of Action of a Direct Inhibitor of Mycobacterium abscessus InhA.
Acs Infect Dis., 8, 2022
7AGO
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BU of 7ago by Molmil
crystal structure of the N-acetylmuramyl-L-alanine amidase, Ami1, from Mycobacterium abscessus bound to L-Alanine-D-isoglutamine
Descriptor: ALANINE, D-alpha-glutamine, N-acetylmuramoyl-L-alanine amidase, ...
Authors:Blaise, M.
Deposit date:2020-09-23
Release date:2020-11-18
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Functional Characterization of the N -Acetylmuramyl-l-Alanine Amidase, Ami1, from Mycobacterium abscessus .
Cells, 9, 2020
7AGM
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BU of 7agm by Molmil
Crystal structure of the N-acetylmuramyl-L-alanine amidase, Ami1, from Mycobacterium smegmatis
Descriptor: N-acetylmuramoyl-L-alanine amidase, ZINC ION
Authors:Blaise, M, Alsarraf, M.A.B.
Deposit date:2020-09-23
Release date:2020-11-18
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Functional Characterization of the N -Acetylmuramyl-l-Alanine Amidase, Ami1, from Mycobacterium abscessus .
Cells, 9, 2020
7AGL
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BU of 7agl by Molmil
crystal structure of the apo form of the N-acetylmuramyl-L-alanine amidase, Ami1, from Mycobacterium abscessus.
Descriptor: N-acetylmuramoyl-L-alanine amidase, ZINC ION
Authors:Blaise, M.
Deposit date:2020-09-23
Release date:2020-11-18
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Functional Characterization of the N -Acetylmuramyl-l-Alanine Amidase, Ami1, from Mycobacterium abscessus .
Cells, 9, 2020
6SHW
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BU of 6shw by Molmil
N-terminal domain of Drosophila X Virus VP3
Descriptor: SULFATE ION, Structural polyprotein
Authors:Ferrero, D.S, Garriga, D, Guerra, P, Uson, I, Verdaguer, N.
Deposit date:2019-08-08
Release date:2020-11-18
Last modified:2024-05-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure and dsRNA-binding activity of the Birnavirus Drosophila X Virus VP3 protein.
J.Virol., 2020
6SI6
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BU of 6si6 by Molmil
N-terminal domain of Drosophila X virus VP3
Descriptor: GLYCEROL, IMIDAZOLE, Structural polyprotein
Authors:Ferrero, D.S, Garriga, D, Guerra, P, Uson, I, Verdaguer, N.
Deposit date:2019-08-08
Release date:2020-11-18
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Structure and dsRNA-binding activity of the Birnavirus Drosophila X Virus VP3 protein.
J.Virol., 2020
2KB3
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BU of 2kb3 by Molmil
NMR Structure of the phosphorylated form of OdhI, pOdhI.
Descriptor: Oxoglutarate dehydrogenase inhibitor
Authors:Barthe, P, Roumestand, C, Canova, M, Hurard, C, Molle, V, Cohen-Gonsaud, M.
Deposit date:2008-11-20
Release date:2009-05-05
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Dynamic and Structural Characterization of a Bacterial FHA Protein Reveals a New Autoinhibition Mechanism.
Structure, 17, 2009
2KB4
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BU of 2kb4 by Molmil
NMR structure of the unphosphorylated form of OdhI, OdhI.
Descriptor: Oxoglutarate dehydrogenase inhibitor
Authors:Barthe, P, Roumestand, C, Canova, M, Hurard, C, Molle, V, Cohen-Gonsaud, M.
Deposit date:2008-11-20
Release date:2009-05-05
Last modified:2024-05-08
Method:SOLUTION NMR
Cite:Dynamic and Structural Characterization of a Bacterial FHA Protein Reveals a New Autoinhibition Mechanism.
Structure, 17, 2009
2KFS
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BU of 2kfs by Molmil
NMR structure of Rv2175c
Descriptor: Conserved hypothetical regulatory protein
Authors:Barthe, P, Cohen-Gonsaud, M, Roumestand, C, Molle, V.
Deposit date:2009-02-27
Release date:2009-05-19
Last modified:2024-05-08
Method:SOLUTION NMR
Cite:The Mycobacterium tuberculosis Ser/Thr Kinase Substrate Rv2175c Is a DNA-binding Protein Regulated by Phosphorylation.
J.Biol.Chem., 284, 2009
2NV6
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BU of 2nv6 by Molmil
Mycobacterium tuberculosis InhA (S94A) bound with INH-NAD adduct
Descriptor: Enoyl-[acyl-carrier-protein] reductase [NADH, ISONICOTINIC-ACETYL-NICOTINAMIDE-ADENINE DINUCLEOTIDE
Authors:Wang, F, Sacchettini, J.C.
Deposit date:2006-11-10
Release date:2006-11-21
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Transfer of a point mutation in Mycobacterium tuberculosis inhA resolves the target of isoniazid.
NAT.MED. (N.Y.), 12, 2006
2GEJ
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BU of 2gej by Molmil
Crystal Structure of phosphatidylinositol mannosyltransferase (PimA) from Mycobacterium smegmatis in complex with GDP-Man
Descriptor: GUANOSINE-5'-DIPHOSPHATE-ALPHA-D-MANNOSE, PHOSPHATIDYLINOSITOL MANNOSYLTRANSFERASE (PimA)
Authors:Guerin, M.E, Buschiazzo, A, Kordulakova, J, Jackson, M, Alzari, P.M.
Deposit date:2006-03-20
Release date:2007-04-03
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Molecular recognition and interfacial catalysis by the essential phosphatidylinositol mannosyltransferase PimA from mycobacteria.
J.Biol.Chem., 282, 2007
2GEK
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BU of 2gek by Molmil
Crystal Structure of phosphatidylinositol mannosyltransferase (PimA) from Mycobacterium smegmatis in complex with GDP
Descriptor: GUANOSINE-5'-DIPHOSPHATE, PHOSPHATIDYLINOSITOL MANNOSYLTRANSFERASE (PimA)
Authors:Guerin, M.E, Buschiazzo, A, Kordulakova, J, Jackson, M, Alzari, P.M.
Deposit date:2006-03-20
Release date:2007-04-03
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Molecular recognition and interfacial catalysis by the essential phosphatidylinositol mannosyltransferase PimA from mycobacteria.
J.Biol.Chem., 282, 2007
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