7U0O

Crystal structure of an enoyl-[acyl-carrier-protein] reductase InhA from Mycobacterium fortuitum bound to NAD and NITD-916

Summary for 7U0O

Entry DOI	10.2210/pdb7u0o/pdb
Descriptor	Enoyl-[acyl-carrier-protein] reductase [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE, 6-[(4,4-dimethylcyclohexyl)methyl]-4-hydroxy-3-phenylpyridin-2(1H)-one, ... (6 entities in total)
Functional Keywords	inha, mycobacterium, pulmonary infection, cf, nad-depdendent enzyme, structural genomics, seattle structural genomics center for infectious disease, ssgcid, oxidoreductase
Biological source	Mycolicibacterium fortuitum
Total number of polymer chains	2
Total formula weight	60880.10
Authors	Seattle Structural Genomics Center for Infectious Disease,Seattle Structural Genomics Center for Infectious Disease (SSGCID) (deposition date: 2022-02-18, release date: 2023-02-22, Last modification date: 2023-10-25)
Primary citation	Roquet-Baneres, F.,Alcaraz, M.,Hamela, C.,Abendroth, J.,Edwards, T.E.,Kremer, L. In Vitro and In Vivo Efficacy of NITD-916 against Mycobacterium fortuitum. Antimicrob.Agents Chemother., 67:e0160722-e0160722, 2023 Cited by PubMed: 36920188 DOI: 10.1128/aac.01607-22 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.05 Å)

Structure validation