7KLI

Crystal Structure of Enoyl-[acyl-carrier-protein] reductase [NADH] (InhA) from Mycobacterium abscessus

Summary for 7KLI

• Entry DOI: 10.2210/pdb7kli/pdb
• Descriptor: Enoyl-[acyl-carrier-protein] reductase [NADH], 1,2-ETHANEDIOL, SULFATE ION, ... (4 entities in total)
• Functional Keywords: ssgcid, enoyl-[acyl-carrier-protein] reductase, inha, mab_2722c, structural genomics, seattle structural genomics center for infectious disease, oxidoreductase
• Biological source: Mycobacteroides abscessus (strain ATCC 19977 / DSM 44196 / CIP 104536 / JCM 13569 / NCTC 13031 / TMC 1543)
• Total number of polymer chains: 4
• Total formula weight: 119921.21

Authors

Seattle Structural Genomics Center for Infectious Disease (SSGCID) (deposition date: 2020-10-30, release date: 2020-11-11, Last modification date: 2023-10-18)

• Primary citation: Alcaraz, M.,Roquet-Baneres, F.,Leon-Icaza, S.A.,Abendroth, J.,Boudehen, Y.M.,Cougoule, C.,Edwards, T.E.,Kremer, L.; Efficacy and Mode of Action of a Direct Inhibitor of Mycobacterium abscessus InhA.; Acs Infect Dis., 8:2171-2186, 2022; PubMed: 36107992; DOI: 10.1021/acsinfecdis.2c00314

Experimental method

X-RAY DIFFRACTION (1.75 Å)