7L6C

Crystal Structure of Enoyl-[acyl-carrier-protein] reductase InhA from Mycobacterium abscessus in complex with NAD

Summary for 7L6C

• Entry DOI: 10.2210/pdb7l6c/pdb
• Related: 7KLI
• Descriptor: Enoyl-[acyl-carrier-protein] reductase [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE, 1,2-ETHANEDIOL, ... (5 entities in total)
• Functional Keywords: ssgcid, enoyl-[acyl-carrier-protein] reductase, inha, mab_2722c, nad, structural genomics, seattle structural genomics center for infectious disease, oxidoreductase
• Biological source: Mycobacteroides abscessus (strain ATCC 19977 / DSM 44196 / CIP 104536 / JCM 13569 / NCTC 13031 / TMC 1543)
• Total number of polymer chains: 4
• Total formula weight: 121650.09

Authors

Seattle Structural Genomics Center for Infectious Disease (SSGCID) (deposition date: 2020-12-23, release date: 2021-01-13, Last modification date: 2023-10-18)

• Primary citation: Alcaraz, M.,Roquet-Baneres, F.,Leon-Icaza, S.A.,Abendroth, J.,Boudehen, Y.M.,Cougoule, C.,Edwards, T.E.,Kremer, L.; Efficacy and Mode of Action of a Direct Inhibitor of Mycobacterium abscessus InhA.; Acs Infect Dis., 8:2171-2186, 2022; PubMed: 36107992; DOI: 10.1021/acsinfecdis.2c00314

Experimental method

X-RAY DIFFRACTION (1.85 Å)