7U0M

Crystal structure of a enoyl-[acyl-carrier-protein] reductase (InhA) from Mycobacterium abscessus bound to NAD and NITD-916

Summary for 7U0M

Entry DOI	10.2210/pdb7u0m/pdb
Descriptor	Enoyl-[acyl-carrier-protein] reductase [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE, 6-[(4,4-dimethylcyclohexyl)methyl]-4-hydroxy-3-phenylpyridin-2(1H)-one, ... (5 entities in total)
Functional Keywords	inha, mycobacterium, tuberculosis, cystic fibrosis, cf, pulmonary infections, structural genomics, seattle structural genomics center for infectious disease, ssgcid, oxidoreductase
Biological source	Mycobacteroides abscessus
Total number of polymer chains	2
Total formula weight	61385.81
Authors	Seattle Structural Genomics Center for Infectious Disease,Seattle Structural Genomics Center for Infectious Disease (SSGCID) (deposition date: 2022-02-18, release date: 2022-10-05, Last modification date: 2023-10-18)
Primary citation	Alcaraz, M.,Roquet-Baneres, F.,Leon-Icaza, S.A.,Abendroth, J.,Boudehen, Y.M.,Cougoule, C.,Edwards, T.E.,Kremer, L. Efficacy and Mode of Action of a Direct Inhibitor of Mycobacterium abscessus InhA. Acs Infect Dis., 8:2171-2186, 2022 Cited by PubMed: 36107992 DOI: 10.1021/acsinfecdis.2c00314 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.45 Å)

Structure validation