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2CPL
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BU of 2cpl by Molmil
SIMILARITIES AND DIFFERENCES BETWEEN HUMAN CYCLOPHILIN A AND OTHER BETA-BARREL STRUCTURES. STRUCTURAL REFINEMENT AT 1.63 ANGSTROMS RESOLUTION
分子名称: CYCLOPHILIN A
著者Ke, H.
登録日1992-06-30
公開日1993-10-31
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.63 Å)
主引用文献Similarities and differences between human cyclophilin A and other beta-barrel structures. Structural refinement at 1.63 A resolution.
J.Mol.Biol., 228, 1992
2RMC
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Crystal structure of murine cyclophilin C complexed with immunosuppressive drug cyclosporin A
分子名称: CYCLOSPORIN A, PEPTIDYL-PROLYL CIS-TRANS ISOMERASE C
著者Ke, H, Zhao, Y, Luo, F, Weissman, I, Friedman, J.
登録日1994-01-07
公開日1995-02-14
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (1.64 Å)
主引用文献Crystal Structure of Murine Cyclophilin C Complexed with Immunosuppressive Drug Cyclosporin A
Proc.Natl.Acad.Sci.USA, 90, 1993
2RMA
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Crystal structures of cyclophilin A complexed with cyclosporin A and N-methyl-4-[(E)-2-butenyl]-4,4-dimethylthreonine cyclosporin A
分子名称: CYCLOSPORIN A, PEPTIDYL-PROLYL CIS-TRANS ISOMERASE
著者Ke, H, Mayrose, D.
登録日1994-01-07
公開日1995-02-07
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal Structures of Cyclophilin a Complexed with Cyclosporin a and N-Methyl-4-[(E)-2-Butenyl]-4,4-Dimethylthreonine Cyclosporin A.
Structure, 2, 1994
2RMB
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Crystal structures of cyclophilin A complexed with cyclosporin A and N-methyl-4-[(E)-2-butenyl]-4,4-dimethylthreonine cyclosporin A
分子名称: CYCLOSPORIN A, PEPTIDYL-PROLYL CIS-TRANS ISOMERASE
著者Ke, H, Mayrose, D.
登録日1994-01-07
公開日1995-02-07
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal Structures of Cyclophilin a Complexed with Cyclosporin a and N-Methyl-4-[(E)-2-Butenyl]-4,4-Dimethylthreonine Cyclosporin A.
Structure, 2, 1994
2FBP
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BU of 2fbp by Molmil
STRUCTURE REFINEMENT OF FRUCTOSE-1,6-BISPHOSPHATASE AND ITS FRUCTOSE 2,6-BISPHOSPHATE COMPLEX AT 2.8 ANGSTROMS RESOLUTION
分子名称: FRUCTOSE 1,6-BISPHOSPHATASE
著者Ke, H, Thorpe, C.M, Seaton, B.A, Marcus, F, Lipscomb, W.N.
登録日1990-06-07
公開日1992-04-15
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structure refinement of fructose-1,6-bisphosphatase and its fructose 2,6-bisphosphate complex at 2.8 A resolution.
J.Mol.Biol., 212, 1990
2QYL
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Crystal structure of PDE4B2B in complex with inhibitor NPV
分子名称: 4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acid, MAGNESIUM ION, Phosphodiesterase 4B, ...
著者Ke, H.
登録日2007-08-15
公開日2008-04-08
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Structures of the four subfamilies of phosphodiesterase-4 provide insight into the selectivity of their inhibitors.
Biochem.J., 408, 2007
2QYM
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crystal structure of unliganded PDE4C2
分子名称: MAGNESIUM ION, Phosphodiesterase 4C, ZINC ION
著者Ke, H.
登録日2007-08-15
公開日2008-04-08
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structures of the four subfamilies of phosphodiesterase-4 provide insight into the selectivity of their inhibitors.
Biochem.J., 408, 2007
3FBP
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STRUCTURE REFINEMENT OF FRUCTOSE-1,6-BISPHOSPHATASE AND ITS FRUCTOSE 2,6-BISPHOSPHATE COMPLEX AT 2.8 ANGSTROMS RESOLUTION
分子名称: 2,6-di-O-phosphono-beta-D-fructofuranose, FRUCTOSE 1,6-BISPHOSPHATASE
著者Ke, H, Thorpe, C.M, Seaton, B.A, Marcus, F, Lipscomb, W.N.
登録日1990-06-07
公開日1992-04-15
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structure refinement of fructose-1,6-bisphosphatase and its fructose 2,6-bisphosphate complex at 2.8 A resolution.
J.Mol.Biol., 212, 1990
2QYN
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Crystal structure of PDE4D2 in complex with inhibitor NPV
分子名称: 4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acid, MAGNESIUM ION, ZINC ION, ...
著者Ke, H.
登録日2007-08-15
公開日2008-04-08
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.57 Å)
主引用文献Structures of the four subfamilies of phosphodiesterase-4 provide insight into the selectivity of their inhibitors.
Biochem.J., 408, 2007
6X88
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PDE6 chicken GAF domain
分子名称: Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'
著者Ke, H.
登録日2020-06-01
公開日2020-11-04
実験手法X-RAY DIFFRACTION (3.1997447 Å)
主引用文献Structural Analysis of the Regulatory GAF Domains of cGMP Phosphodiesterase Elucidates the Allosteric Communication Pathway.
J.Mol.Biol., 432, 2020
1FBP
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CRYSTAL STRUCTURE OF FRUCTOSE-1,6-BISPHOSPHATASE COMPLEXED WITH FRUCTOSE 6-PHOSPHATE, AMP, AND MAGNESIUM
分子名称: 6-O-phosphono-beta-D-fructofuranose, ADENOSINE MONOPHOSPHATE, FRUCTOSE 1,6-BISPHOSPHATASE, ...
著者Ke, H, Zhang, Y, Lipscomb, W.N.
登録日1990-05-31
公開日1992-04-15
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal structure of fructose-1,6-bisphosphatase complexed with fructose 6-phosphate, AMP, and magnesium.
Proc.Natl.Acad.Sci.USA, 87, 1990
4FBP
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CONFORMATIONAL TRANSITION OF FRUCTOSE-1,6-BISPHOSPHATASE: STRUCTURE COMPARISON BETWEEN THE AMP COMPLEX (T FORM) AND THE FRUCTOSE 6-PHOSPHATE COMPLEX (R FORM)
分子名称: ADENOSINE MONOPHOSPHATE, FRUCTOSE 1,6-BISPHOSPHATASE
著者Ke, H, Zhang, Y, Liang, J.-Y, Lipscomb, W.N.
登録日1991-02-11
公開日1992-07-15
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Conformational transition of fructose-1,6-bisphosphatase: structure comparison between the AMP complex (T form) and the fructose 6-phosphate complex (R form).
Biochemistry, 30, 1991
6VBI
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crystal structure of PDE5 in complex with a non-competitive inhibitor
分子名称: (13bS)-4,9-dimethoxy-14-methyl-8,13,13b,14-tetrahydroindolo[2',3':3,4]pyrido[2,1-b]quinazolin-5(7H)-one, cGMP-specific 3',5'-cyclic phosphodiesterase
著者Ke, H, Luo, H.B.
登録日2019-12-18
公開日2021-01-20
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.30000758 Å)
主引用文献Identification of a novel allosteric pocket and its regulation mechanism
To Be Published
6CPT
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crystal structure of yeast caPDE2 in complex with IBMX
分子名称: 3-ISOBUTYL-1-METHYLXANTHINE, MAGNESIUM ION, Phosphodiesterase, ...
著者Ke, h, Wang, Y.
登録日2018-03-14
公開日2019-02-20
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal Structures of Candida albicans Phosphodiesterase 2 and Implications for Its Biological Functions.
Biochemistry, 57, 2018
6CPU
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Crystal structure of yeast caPDE2
分子名称: MAGNESIUM ION, Phosphodiesterase, ZINC ION
著者Ke, H, Wang, y.
登録日2018-03-14
公開日2019-02-20
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal Structures of Candida albicans Phosphodiesterase 2 and Implications for Its Biological Functions.
Biochemistry, 57, 2018
8ATC
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COMPLEX OF N-PHOSPHONACETYL-L-ASPARTATE WITH ASPARTATE CARBAMOYLTRANSFERASE. X-RAY REFINEMENT, ANALYSIS OF CONFORMATIONAL CHANGES AND CATALYTIC AND ALLOSTERIC MECHANISMS
分子名称: ASPARTATE CARBAMOYLTRANSFERASE (R STATE), CATALYTIC CHAIN, ASPARTATE CARBAMOYLTRANSFERASE REGULATORY CHAIN, ...
著者Ke, H, Lipscomb, W.N, Cho, Y, Honzatko, R.B.
登録日1989-08-25
公開日1990-10-15
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Complex of N-phosphonacetyl-L-aspartate with aspartate carbamoyltransferase. X-ray refinement, analysis of conformational changes and catalytic and allosteric mechanisms.
J.Mol.Biol., 204, 1988
5FBP
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CRYSTAL STRUCTURE OF THE NEUTRAL FORM OF FRUCTOSE-1,6-BISPHOSPHATASE COMPLEXED WITH THE PRODUCT FRUCTOSE 6-PHOSPHATE AT 2.1-ANGSTROMS RESOLUTION
分子名称: 6-O-phosphono-beta-D-fructofuranose, FRUCTOSE 1,6-BISPHOSPHATASE
著者Ke, H, Liang, J.-Y, Zhang, Y, Lipscomb, W.N.
登録日1991-02-11
公開日1992-07-15
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal structure of the neutral form of fructose-1,6-bisphosphatase complexed with the product fructose 6-phosphate at 2.1-A resolution.
Proc.Natl.Acad.Sci.USA, 88, 1991
5X9S
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Crystal structure of fully modified H-Ras-GppNHp
分子名称: CALCIUM ION, GTPase HRas, MAGNESIUM ION, ...
著者Matsumoto, S, Ke, H, Murashima, Y, Taniguchi-Tamura, H, Miyamoto, R, Yoshikawa, Y, Kumasaka, T, Mizohata, E, Edamatsu, H, Kataoka, T.
登録日2017-03-09
公開日2017-08-30
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural basis for intramolecular interaction of post-translationally modified H-RasGTP prepared by protein ligation
FEBS Lett., 591, 2017
5WH6
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Crystal structure of PDE4D2 in complex with inhibitor (S_Zl-n-91)
分子名称: 1-[4-(difluoromethoxy)-3-{[(3S)-oxolan-3-yl]oxy}phenyl]-3-methylbutan-1-one, MAGNESIUM ION, ZINC ION, ...
著者Ke, H, Wang, H.
登録日2017-07-14
公開日2018-07-18
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Identification of a PDE4-Specific Pocket for the Design of Selective Inhibitors.
Biochemistry, 57, 2018
2FM5
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Crystal structure of PDE4D2 in complex with inhibitor L-869299
分子名称: (R)-3-(2-(3-CYCLOPROPOXY-4-(DIFLUOROMETHOXY)PHENYL)-2-(5-(1,1,1,3,3,3-HEXAFLUORO-2-HYDROXYPROPAN-2-YL)THIAZOL-2-YL)ETHYL)PYRIDINE 1-OXIDE, MAGNESIUM ION, ZINC ION, ...
著者Huai, Q, Sun, Y, Wang, H, Macdonald, D, Aspiotis, R, Robinson, H, Huang, Z, Ke, H.
登録日2006-01-07
公開日2006-03-28
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.03 Å)
主引用文献Enantiomer Discrimination Illustrated by the High Resolution Crystal Structures of Type 4 Phosphodiesterase
J.Med.Chem., 49, 2006
2FM0
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Crystal structure of PDE4D in complex with L-869298
分子名称: (S)-3-(2-(3-CYCLOPROPOXY-4-(DIFLUOROMETHOXY)PHENYL)-2-(5-(1,1,1,3,3,3-HEXAFLUORO-2-HYDROXYPROPAN-2-YL)THIAZOL-2-YL)ETHY L)PYRIDINE 1-OXIDE, MAGNESIUM ION, ZINC ION, ...
著者Huai, Q, Sun, Y, Wang, H, Macdonald, D, Aspiotis, R, Robinson, H, Huang, Z, Ke, H.
登録日2006-01-06
公開日2006-03-28
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Enantiomer Discrimination Illustrated by the High Resolution Crystal Structures of Type 4 Phosphodiesterase
J.Med.Chem., 49, 2006
4EKZ
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Crystal structure of reduced hPDI (abb'xa')
分子名称: Protein disulfide-isomerase
著者Wang, C, Li, W, Ren, J, Ke, H, Gong, W, Feng, W, Wang, C.-C.
登録日2012-04-10
公開日2013-04-10
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.51 Å)
主引用文献Structural insights into the redox-regulated dynamic conformations of human protein disulfide isomerase
Antioxid Redox Signal, 19, 2013
4EL1
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Crystal structure of oxidized hPDI (abb'xa')
分子名称: Protein disulfide-isomerase
著者Wang, C, Li, W, Ren, J, Ke, H, Gong, W, Feng, W, Wang, C.-C.
登録日2012-04-10
公開日2013-04-10
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.883 Å)
主引用文献Structural insights into the redox-regulated dynamic conformations of human protein disulfide isomerase
Antioxid Redox Signal, 19, 2013
3ECN
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Crystal structure of PDE8A catalytic domain in complex with IBMX
分子名称: 3-ISOBUTYL-1-METHYLXANTHINE, High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A, MAGNESIUM ION, ...
著者Wang, H, Yan, Z, Yang, S, Cai, J, Robinson, H, Ke, H.
登録日2008-09-01
公開日2008-11-25
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Kinetic and structural studies of phosphodiesterase-8A and implication on the inhibitor selectivity
Biochemistry, 47, 2008
3ECM
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Crystal structure of the unliganded PDE8A catalytic domain
分子名称: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A, MAGNESIUM ION, ZINC ION
著者Wang, H, Yan, Z, Yang, S, Cai, J, Robinson, H, Ke, H.
登録日2008-09-01
公開日2008-11-25
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Kinetic and structural studies of phosphodiesterase-8A and implication on the inhibitor selectivity
Biochemistry, 47, 2008

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