5WH6

Crystal structure of PDE4D2 in complex with inhibitor (S_Zl-n-91)

Summary for 5WH6

• Entry DOI: 10.2210/pdb5wh6/pdb
• Descriptor: cAMP-specific 3',5'-cyclic phosphodiesterase 4D, 1-[4-(difluoromethoxy)-3-{[(3S)-oxolan-3-yl]oxy}phenyl]-3-methylbutan-1-one, ZINC ION, ... (5 entities in total)
• Functional Keywords: phosphodiesterase, inhibitor zl-n-91, pde4d-s91 complex, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 116551.39

Authors

Ke, H.,Wang, H. (deposition date: 2017-07-14, release date: 2018-07-18, Last modification date: 2024-03-13)

• Primary citation: Feng, X.,Wang, H.,Ye, M.,Xu, X.T.,Xu, Y.,Yang, W.,Zhang, H.T.,Song, G.,Ke, H.; Identification of a PDE4-Specific Pocket for the Design of Selective Inhibitors.; Biochemistry, 57:4518-4525, 2018; PubMed: 29975048; DOI: 10.1021/acs.biochem.8b00336

Experimental method

X-RAY DIFFRACTION (1.6 Å)