6VBI

crystal structure of PDE5 in complex with a non-competitive inhibitor

Summary for 6VBI

• Entry DOI: 10.2210/pdb6vbi/pdb
• Descriptor: cGMP-specific 3',5'-cyclic phosphodiesterase, (13bS)-4,9-dimethoxy-14-methyl-8,13,13b,14-tetrahydroindolo[2',3':3,4]pyrido[2,1-b]quinazolin-5(7H)-one (3 entities in total)
• Functional Keywords: pde5, allosteric regulation, non-competitive inhibitors, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 76047.62

Authors

Ke, H.,Luo, H.B. (deposition date: 2019-12-18, release date: 2021-01-20, Last modification date: 2024-10-30)

• Primary citation: Zhang, T.,Ke, H.,Luo, H.; Identification of a novel allosteric pocket and its regulation mechanism; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.30000752706 Å)