6VBI
crystal structure of PDE5 in complex with a non-competitive inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | cGMP-specific 3',5'-cyclic phosphodiesterase | polymer | 325 | 37660.4 | 2 | UniProt (O76074) Pfam (PF00233) | Homo sapiens (Human) | cGMP-binding cGMP-specific phosphodiesterase,CGB-PDE |
| 2 | C, D (A, B) | (13bS)-4,9-dimethoxy-14-methyl-8,13,13b,14-tetrahydroindolo[2',3':3,4]pyrido[2,1-b]quinazolin-5(7H)-one | non-polymer | 363.4 | 2 | Chemie (FZA) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 146 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 75320.8 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 726.8 | |
| All* | Total formula weight | 76047.6 |
