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CRYSTAL AND MOLECULAR STRUCTURE OF HUMAN ANNEXIN V AFTER REFINEMENT. IMPLICATIONS FOR STRUCTURE, MEMBRANE BINDING AND ION CHANNEL FORMATION OF THE ANNEXIN FAMILY OF PROTEINS
分子名称:	ANNEXIN V, CALCIUM ION, SULFATE ION
著者	Huber, R, Berendes, R, Burger, A, Schneider, M, Karshikov, A, Luecke, H, Roemisch, J, Paques, E.
登録日	1991-10-17
公開日	1994-01-31
最終更新日	2024-02-07
実験手法	X-RAY DIFFRACTION (2.3 Å)
主引用文献	Crystal and molecular structure of human annexin V after refinement. Implications for structure, membrane binding and ion channel formation of the annexin family of proteins. J.Mol.Biol., 223, 1992

1AVR

CRYSTAL AND MOLECULAR STRUCTURE OF HUMAN ANNEXIN V AFTER REFINEMENT. IMPLICATIONS FOR STRUCTURE, MEMBRANE BINDING AND ION CHANNEL FORMATION OF THE ANNEXIN FAMILY OF PROTEINS
分子名称:	ANNEXIN V, CALCIUM ION, SULFATE ION
著者	Huber, R, Berendes, R, Burger, A, Schneider, M, Karshikov, A, Luecke, H, Roemisch, J, Paques, E.
登録日	1991-10-17
公開日	1994-01-31
最終更新日	2024-02-07
実験手法	X-RAY DIFFRACTION (2.3 Å)
主引用文献	Crystal and molecular structure of human annexin V after refinement. Implications for structure, membrane binding and ion channel formation of the annexin family of proteins. J.Mol.Biol., 223, 1992

1AIX

HUMAN ALPHA-THROMBIN TERNARY COMPLEX WITH EXOSITE INHIBITOR HIRUGEN AND ACTIVE SITE INHIBITOR PHCH2OCO-D-DPA-PRO-BOROVAL
分子名称:	ALPHA-THROMBIN (LARGE SUBUNIT), ALPHA-THROMBIN (SMALL SUBUNIT), HIRUGEN, ...
著者	Skordalakes, E, Dodson, G, Elgendy, S, Goodwin, C.A, Green, D, Tyrrel, R, Scully, M.F, Freyssinet, J, Kakkar, V.V, Deadman, J.
登録日	1997-04-30
公開日	1997-10-15
最終更新日	2013-03-13
実験手法	X-RAY DIFFRACTION (2.1 Å)
主引用文献	The refined 1.9-A X-ray crystal structure of D-Phe-Pro-Arg chloromethylketone-inhibited human alpha-thrombin: structure analysis, overall structure, electrostatic properties, detailed active-site geometry, and structure-function relationships. Protein Sci., 1, 1992

1AI8

HUMAN ALPHA-THROMBIN TERNARY COMPLEX WITH THE EXOSITE INHIBITOR HIRUGEN AND ACTIVE SITE INHIBITOR PHCH2OCO-D-DPA-PRO-BOROMPG
分子名称:	ALPHA-THROMBIN (LARGE SUBUNIT), ALPHA-THROMBIN (SMALL SUBUNIT), HIRUDIN IIIB, ...
著者	Skordalakes, E, Dodson, G, Elgendy, S, Goodwin, C.A, Green, D, Tyrrel, R, Scully, M.F, Freyssinet, J, Kakkar, V.V, Deadman, J.
登録日	1997-05-01
公開日	1997-10-15
最終更新日	2023-08-02
実験手法	X-RAY DIFFRACTION (1.85 Å)
主引用文献	The refined 1.9-A X-ray crystal structure of D-Phe-Pro-Arg chloromethylketone-inhibited human alpha-thrombin: structure analysis, overall structure, electrostatic properties, detailed active-site geometry, and structure-function relationships. Protein Sci., 1, 1992

1PPB

THE REFINED 1.9 ANGSTROMS CRYSTAL STRUCTURE OF HUMAN ALPHA-THROMBIN: INTERACTION WITH D-PHE-PRO-ARG CHLOROMETHYLKETONE AND SIGNIFICANCE OF THE TYR-PRO-PRO-TRP INSERTION SEGMENT
分子名称:	ALPHA-THROMBIN (LARGE SUBUNIT), ALPHA-THROMBIN (SMALL SUBUNIT), D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide
著者	Bode, W.
登録日	1991-10-24
公開日	1994-01-31
最終更新日	2013-02-27
実験手法	X-RAY DIFFRACTION (1.92 Å)
主引用文献	The refined 1.9 A crystal structure of human alpha-thrombin: interaction with D-Phe-Pro-Arg chloromethylketone and significance of the Tyr-Pro-Pro-Trp insertion segment. EMBO J., 8, 1989

1TBQ

CRYSTAL STRUCTURE OF INSECT DERIVED DOUBLE DOMAIN KAZAL INHIBITOR RHODNIIN IN COMPLEX WITH THROMBIN
分子名称:	RHODNIIN, THROMBIN
著者	Van De Locht, A, Lamba, D, Bode, W.
登録日	1995-03-02
公開日	1996-10-14
最終更新日	2011-07-13
実験手法	X-RAY DIFFRACTION (3.1 Å)
主引用文献	Two heads are better than one: crystal structure of the insect derived double domain Kazal inhibitor rhodniin in complex with thrombin. EMBO J., 14, 1995

1TBR

CRYSTAL STRUCTURE OF INSECT DERIVED DOUBLE DOMAIN KAZAL INHIBITOR RHODNIIN IN COMPLEX WITH THROMBIN
分子名称:	RHODNIIN, THROMBIN
著者	Van De Locht, A, Lamba, D, Bode, W.
登録日	1995-03-03
公開日	1996-10-14
最終更新日	2011-07-13
実験手法	X-RAY DIFFRACTION (2.6 Å)
主引用文献	Two heads are better than one: crystal structure of the insect derived double domain Kazal inhibitor rhodniin in complex with thrombin. EMBO J., 14, 1995

1SAV

HUMAN ANNEXIN V WITH PROLINE SUBSTITUTION BY THIOPROLINE
分子名称:	ANNEXIN V, CALCIUM ION
著者	Medrano, F.J, Minks, C, Budisa, N, Huber, R.
登録日	1997-11-24
公開日	1998-05-27
最終更新日	2023-08-09
実験手法	X-RAY DIFFRACTION (2.5 Å)
主引用文献	Crystal and molecular structure of human annexin V after refinement. Implications for structure, membrane binding and ion channel formation of the annexin family of proteins. J.Mol.Biol., 223, 1992

1CEW

THE 2.0 ANGSTROMS X-RAY CRYSTAL STRUCTURE OF CHICKEN EGG WHITE CYSTATIN AND ITS POSSIBLE MODE OF INTERACTION WITH CYSTEINE PROTEINASES
分子名称:	CYSTATIN
著者	Bode, W, Musil, D, Huber, R.
登録日	1993-04-21
公開日	1994-01-31
最終更新日	2011-09-07
実験手法	X-RAY DIFFRACTION (2 Å)
主引用文献	The 2.0 A X-ray crystal structure of chicken egg white cystatin and its possible mode of interaction with cysteine proteinases. EMBO J., 7, 1988

1HVE

STRUCTURAL AND ELECTROPHYSIOLOGICAL ANALYSIS OF ANNEXIN V MUTANTS. MUTAGENESIS OF HUMAN ANNEXIN V, AN IN VITRO VOLTAGE-GATED CALCIUM CHANNEL, PROVIDES INFORMATION ABOUT THE STRUCTURAL FEATURES OF THE ION PATHWAY, THE VOLTAGE SENSOR AND THE ION SELECTIVITY FILTER
分子名称:	ANNEXIN V, CALCIUM ION, SULFATE ION
著者	Burger, A, Huber, R.
登録日	1994-06-29
公開日	1995-03-31
最終更新日	2024-02-07
実験手法	X-RAY DIFFRACTION (2.3 Å)
主引用文献	Structural and electrophysiological analysis of annexin V mutants. Mutagenesis of human annexin V, an in vitro voltage-gated calcium channel, provides information about the structural features of the ion pathway, the voltage sensor and the ion selectivity filter J.Mol.Biol., 237, 1994

1HVG

STRUCTURAL AND ELECTROPHYSIOLOGICAL ANALYSIS OF ANNEXIN V MUTANTS. MUTAGENESIS OF HUMAN ANNEXIN V, AN IN VITRO VOLTAGE-GATED CALCIUM CHANNEL, PROVIDES INFORMATION ABOUT THE STRUCTURAL FEATURES OF THE ION PATHWAY, THE VOLTAGE SENSOR AND THE ION SELECTIVITY FILTER
分子名称:	ANNEXIN V
著者	Burger, A, Huber, R.
登録日	1994-06-29
公開日	1995-03-31
最終更新日	2024-02-07
実験手法	X-RAY DIFFRACTION (3 Å)
主引用文献	Structural and electrophysiological analysis of annexin V mutants. Mutagenesis of human annexin V, an in vitro voltage-gated calcium channel, provides information about the structural features of the ion pathway, the voltage sensor and the ion selectivity filter J.Mol.Biol., 237, 1994

1HVF

STRUCTURAL AND ELECTROPHYSIOLOGICAL ANALYSIS OF ANNEXIN V MUTANTS. MUTAGENESIS OF HUMAN ANNEXIN V, AN IN VITRO VOLTAGE-GATED CALCIUM CHANNEL, PROVIDES INFORMATION ABOUT THE STRUCTURAL FEATURES OF THE ION PATHWAY, THE VOLTAGE SENSOR AND THE ION SELECTIVITY FILTER
分子名称:	ANNEXIN V, CALCIUM ION, SULFATE ION
著者	Burger, A, Huber, R.
登録日	1994-06-29
公開日	1995-03-31
最終更新日	2024-02-07
実験手法	X-RAY DIFFRACTION (2 Å)
主引用文献	Structural and electrophysiological analysis of annexin V mutants. Mutagenesis of human annexin V, an in vitro voltage-gated calcium channel, provides information about the structural features of the ion pathway, the voltage sensor and the ion selectivity filter J.Mol.Biol., 237, 1994

1HVD

STRUCTURAL AND ELECTROPHYSIOLOGICAL ANALYSIS OF ANNEXIN V MUTANTS. MUTAGENESIS OF HUMAN ANNEXIN V, AN IN VITRO VOLTAGE-GATED CALCIUM CHANNEL, PROVIDES INFORMATION ABOUT THE STRUCTURAL FEATURES OF THE ION PATHWAY, THE VOLTAGE SENSOR AND THE ION SELECTIVITY FILTER
分子名称:	ANNEXIN V, CALCIUM ION
著者	Burger, A, Huber, R.
登録日	1994-06-29
公開日	1995-03-31
最終更新日	2024-02-07
実験手法	X-RAY DIFFRACTION (2 Å)
主引用文献	Structural and electrophysiological analysis of annexin V mutants. Mutagenesis of human annexin V, an in vitro voltage-gated calcium channel, provides information about the structural features of the ion pathway, the voltage sensor and the ion selectivity filter J.Mol.Biol., 237, 1994

1HAK

CRYSTAL STRUCTURE OF RECOMBINANT HUMAN PLACENTAL ANNEXIN V COMPLEXED WITH K-201 AS A CALCIUM CHANNEL ACTIVITY INHIBITOR
分子名称:	4-[3-{1-(4-BENZYL)PIPERODINYL}PROPIONYL]-7-METHOXY-2,3,4,5-TERTRAHYDRO-1,4-BENZOTHIAZEPINE, ANNEXIN V
著者	Ago, H, Inagaki, E, Miyano, M.
登録日	1997-12-10
公開日	1999-02-16
最終更新日	2023-08-09
実験手法	X-RAY DIFFRACTION (3 Å)
主引用文献	Crystal structure of annexin V with its ligand K-201 as a calcium channel activity inhibitor. J.Mol.Biol., 274, 1997

1G96

HUMAN CYSTATIN C; DIMERIC FORM WITH 3D DOMAIN SWAPPING
分子名称:	CHLORIDE ION, CYSTATIN C, GLYCEROL
著者	Janowski, R, Kozak, M, Jankowska, E, Grzonka, Z, Grubb, A, Abrahamson, M, Jaskolski, M.
登録日	2000-11-22
公開日	2001-04-06
最終更新日	2023-08-09
実験手法	X-RAY DIFFRACTION (2.5 Å)
主引用文献	Human cystatin C, an amyloidogenic protein, dimerizes through three-dimensional domain swapping. Nat.Struct.Biol., 8, 2001

1DOJ

Crystal structure of human alpha-thrombin*RWJ-51438 complex at 1.7 A
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, ALPHA-THROMBIN, HIRUGEN, ...
著者	Recacha, R, Costanzo, M.J, Maryanoff, B.E, Carson, M, DeLucas, L, Chattopadhyay, D.
登録日	1999-12-21
公開日	2000-11-03
最終更新日	2024-03-13
実験手法	X-RAY DIFFRACTION (1.7 Å)
主引用文献	Structure of human alpha-thrombin complexed with RWJ-51438 at 1.7 A: unusual perturbation of the 60A-60I insertion loop. Acta Crystallogr.,Sect.D, 56, 2000

1FPH

THE INTERACTION OF THROMBIN WITH FIBRINOGEN: A STRUCTURAL BASIS FOR ITS SPECIFICITY
分子名称:	ALPHA-THROMBIN (LARGE SUBUNIT), ALPHA-THROMBIN (SMALL SUBUNIT), FIBRINOPEPTIDE A, ...
著者	Stubbs, M.T, Bode, W.
登録日	1993-04-21
公開日	1994-01-31
最終更新日	2012-12-12
実験手法	X-RAY DIFFRACTION (2.5 Å)
主引用文献	The interaction of thrombin with fibrinogen. A structural basis for its specificity. Eur.J.Biochem., 206, 1992

1DWB

CRYSTALLOGRAPHIC ANALYSIS AT 3.0-ANGSTROMS RESOLUTION OF THE BINDING TO HUMAN THROMBIN OF FOUR ACTIVE SITE-DIRECTED INHIBITORS
分子名称:	ALPHA-THROMBIN (LARGE SUBUNIT), ALPHA-THROMBIN (SMALL SUBUNIT), BENZAMIDINE, ...
著者	Banner, D.W, Hadvary, P.
登録日	1992-08-19
公開日	1994-01-31
最終更新日	2011-07-13
実験手法	X-RAY DIFFRACTION (3.16 Å)
主引用文献	Crystallographic analysis at 3.0-A resolution of the binding to human thrombin of four active site-directed inhibitors. J.Biol.Chem., 266, 1991

1DWE

Crystallographic analysis at 3.0-Angstroms resolution of the binding to human thrombin of four active site-directed inhibitors
分子名称:	ALPHA-THROMBIN heavy chain, ALPHA-THROMBIN light chain, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, ...
著者	Banner, D.W, Hadvary, P.
登録日	1992-08-19
公開日	1994-01-31
最終更新日	2013-02-27
実験手法	X-RAY DIFFRACTION (3 Å)
主引用文献	Crystallographic analysis at 3.0-A resolution of the binding to human thrombin of four active site-directed inhibitors. J.Biol.Chem., 266, 1991

1DWD

CRYSTALLOGRAPHIC ANALYSIS AT 3.0-ANGSTROMS RESOLUTION OF THE BINDING TO HUMAN THROMBIN OF FOUR ACTIVE SITE-DIRECTED INHIBITORS
分子名称:	1-[N-(naphthalen-2-ylsulfonyl)glycyl-4-carbamimidoyl-D-phenylalanyl]piperidine, ALPHA-THROMBIN (LARGE SUBUNIT), ALPHA-THROMBIN (SMALL SUBUNIT), ...
著者	Banner, D.W, Hadvary, P.
登録日	1992-08-19
公開日	1994-01-31
最終更新日	2012-12-12
実験手法	X-RAY DIFFRACTION (3 Å)
主引用文献	Crystallographic analysis at 3.0-A resolution of the binding to human thrombin of four active site-directed inhibitors. J.Biol.Chem., 266, 1991

1DWC

CRYSTALLOGRAPHIC ANALYSIS AT 3.0-ANGSTROMS RESOLUTION OF THE BINDING TO HUMAN THROMBIN OF FOUR ACTIVE SITE-DIRECTED INHIBITORS
分子名称:	ALPHA-THROMBIN (LARGE SUBUNIT), ALPHA-THROMBIN (SMALL SUBUNIT), HIRUDIN IIIA, ...
著者	Banner, D.W, Hadvary, P.
登録日	1992-08-19
公開日	1994-01-31
最終更新日	2012-12-12
実験手法	X-RAY DIFFRACTION (3 Å)
主引用文献	Crystallographic analysis at 3.0-A resolution of the binding to human thrombin of four active site-directed inhibitors. J.Biol.Chem., 266, 1991

1DE7

INTERACTION OF FACTOR XIII ACTIVATION PEPTIDE WITH ALPHA-THROMBIN: CRYSTAL STRUCTURE OF THE ENZYME-SUBSTRATE COMPLEX
分子名称:	ALPHA-THROMBIN (HEAVY CHAIN), ALPHA-THROMBIN (LIGHT CHAIN), FACTOR XIII ACTIVATION PEPTIDE (28-37), ...
著者	Sadasivan, C, Yee, V.C.
登録日	1999-11-13
公開日	2000-12-13
最終更新日	2023-08-09
実験手法	X-RAY DIFFRACTION (2 Å)
主引用文献	Interaction of the factor XIII activation peptide with alpha -thrombin. Crystal structure of its enzyme-substrate analog complex. J.Biol.Chem., 275, 2000

1PPC

GEOMETRY OF BINDING OF THE BENZAMIDINE-AND ARGININE-BASED INHIBITORS N-ALPHA-(2-NAPHTHYL-SULPHONYL-GLYCYL)-DL-P-AMIDINOPHENYLALANYL-PIPERIDINE (NAPAP) AND (2R,4R)-4-METHYL-1-[N-ALPHA-(3-METHYL-1,2,3,4-TETRAHYDRO-8-QUINOLINESULPHONYL)-L-ARGINYL]-2-PIPERIDINE CARBOXYLIC ACID (MQPA) TO HUMAN ALPHA-THROMBIN: X-RAY CRYSTALLOGRAPHIC DETERMINATION OF THE NAPAP-TRYPSIN COMPLEX AND MODELING OF NAPAP-THROMBIN AND MQPA-THROMBIN
分子名称:	1-[N-(naphthalen-2-ylsulfonyl)glycyl-4-carbamimidoyl-D-phenylalanyl]piperidine, CALCIUM ION, TRYPSIN
著者	Bode, W, Turk, D.
登録日	1991-10-24
公開日	1994-01-31
最終更新日	2012-12-12
実験手法	X-RAY DIFFRACTION (1.8 Å)
主引用文献	Geometry of binding of the benzamidine- and arginine-based inhibitors N alpha-(2-naphthyl-sulphonyl-glycyl)-DL-p-amidinophenylalanyl-pipe ridine (NAPAP) and (2R,4R)-4-methyl-1-[N alpha-(3-methyl-1,2,3,4-tetrahydr quinolinesulphonyl)-L-arginyl]-2-piperidine carboxylic acid (MQPA) to human alpha-thrombin.X-ray crystallographic determination of the NAPAP-trypsin complex and modeling of NAPAP-thrombin and MQPA-thrombin. Eur.J.Biochem., 193, 1990

1E0F

Crystal structure of the human alpha-thrombin-haemadin complex: an exosite II-binding inhibitor
分子名称:	HAEMADIN, THROMBIN
著者	Richardson, J.L, Kroeger, B, Hoefken, W, Pereira, P, Huber, R, Bode, W, Fuentes-Prior, P.
登録日	2000-03-27
公開日	2000-11-03
最終更新日	2023-12-06
実験手法	X-RAY DIFFRACTION (3.1 Å)
主引用文献	Crystal Structure of the Human Alpha-Thrombin-Haemadin Complex: An Exosite II-Binding Inhibitor Embo J., 19, 2000

1ETT

REFINED 2.3 ANGSTROMS X-RAY CRYSTAL STRUCTURE OF BOVINE THROMBIN COMPLEXES FORMED WITH THE BENZAMIDINE AND ARGININE-BASED THROMBIN INHIBITORS NAPAP, 4-TAPAP AND MQPA: A STARTING POINT FOR IMPROVING ANTITHROMBOTICS
分子名称:	4-[(2S)-2-{[(4-methylphenyl)sulfonyl]amino}-3-oxo-3-(piperidin-1-yl)propyl]benzene-1-carboximidamide, EPSILON-THROMBIN
著者	Bode, W, Brandstetter, H.
登録日	1992-07-06
公開日	1994-01-31
最終更新日	2018-09-12
実験手法	X-RAY DIFFRACTION (2.5 Å)
主引用文献	Refined 2.3 A X-ray crystal structure of bovine thrombin complexes formed with the benzamidine and arginine-based thrombin inhibitors NAPAP, 4-TAPAP and MQPA. A starting point for improving antithrombotics. J.Mol.Biol., 226, 1992

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