1DE7

INTERACTION OF FACTOR XIII ACTIVATION PEPTIDE WITH ALPHA-THROMBIN: CRYSTAL STRUCTURE OF THE ENZYME-SUBSTRATE COMPLEX

Summary for 1DE7

• Entry DOI: 10.2210/pdb1de7/pdb
• Descriptor: ALPHA-THROMBIN (LIGHT CHAIN), ALPHA-THROMBIN (HEAVY CHAIN), FACTOR XIII ACTIVATION PEPTIDE (28-37), ... (5 entities in total)
• Functional Keywords: enzyme-substrate complex, alpha-thrombin, factor xiii activation peptide, hydrolase/peptide, blood clotting, hydrolase-hydrolase substrate complex, hydrolase/hydrolase substrate
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted, extracellular space: P00734 P00734
• Total number of polymer chains: 6
• Total formula weight: 70065.01

Authors

Sadasivan, C.,Yee, V.C. (deposition date: 1999-11-13, release date: 2000-12-13, Last modification date: 2023-08-09)

• Primary citation: Sadasivan, C.,Yee, V.C.; Interaction of the factor XIII activation peptide with alpha -thrombin. Crystal structure of its enzyme-substrate analog complex.; J.Biol.Chem., 275:36942-36948, 2000; PubMed: 10956659; DOI: 10.1074/jbc.M006076200

Experimental method

X-RAY DIFFRACTION (2 Å)