1AIX

HUMAN ALPHA-THROMBIN TERNARY COMPLEX WITH EXOSITE INHIBITOR HIRUGEN AND ACTIVE SITE INHIBITOR PHCH2OCO-D-DPA-PRO-BOROVAL

Summary for 1AIX

DescriptorALPHA-THROMBIN (SMALL SUBUNIT), ALPHA-THROMBIN (LARGE SUBUNIT), HIRUGEN, ... (5 entities in total)
Functional Keywordsserine proteinase, blood coagulation, hydrolase-hydrolase inhibitor complex, blood coagulation-hydrolase inhibitor complex, blood coagulation/hydrolase inhibitor
Biological sourceHomo sapiens (human)
More
Cellular locationSecreted, extracellular space P00734 P00734
Secreted P28510
Total number of polymer chains3
Total molecular weight36050.81
Authors
Skordalakes, E.,Dodson, G.,Elgendy, S.,Goodwin, C.A.,Green, D.,Tyrrel, R.,Scully, M.F.,Freyssinet, J.,Kakkar, V.V.,Deadman, J. (deposition date: 1997-04-30, release date: 1997-10-15, Last modification date: 2013-03-13)
Primary citation
Bode, W.,Turk, D.,Karshikov, A.
The refined 1.9-A X-ray crystal structure of D-Phe-Pro-Arg chloromethylketone-inhibited human alpha-thrombin: structure analysis, overall structure, electrostatic properties, detailed active-site geometry, and structure-function relationships.
Protein Sci., 1:426-471, 1992
PubMed: 1304349 (PDB entries with the same primary citation)
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.1 Å)
NMR Information
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Structure validation

ClashscoreRamachandran outliersSidechain outliers120.4%6.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report