1AIX
HUMAN ALPHA-THROMBIN TERNARY COMPLEX WITH EXOSITE INHIBITOR HIRUGEN AND ACTIVE SITE INHIBITOR PHCH2OCO-D-DPA-PRO-BOROVAL
Summary for 1AIX
Entry DOI | 10.2210/pdb1aix/pdb |
Descriptor | ALPHA-THROMBIN (SMALL SUBUNIT), ALPHA-THROMBIN (LARGE SUBUNIT), HIRUGEN, ... (5 entities in total) |
Functional Keywords | serine proteinase, blood coagulation, hydrolase-hydrolase inhibitor complex, blood coagulation-hydrolase inhibitor complex, blood coagulation/hydrolase inhibitor |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted, extracellular space: P00734 P00734 Secreted: P28510 |
Total number of polymer chains | 3 |
Total formula weight | 36050.81 |
Authors | Skordalakes, E.,Dodson, G.,Elgendy, S.,Goodwin, C.A.,Green, D.,Tyrrel, R.,Scully, M.F.,Freyssinet, J.,Kakkar, V.V.,Deadman, J. (deposition date: 1997-04-30, release date: 1997-10-15, Last modification date: 2013-03-13) |
Primary citation | Bode, W.,Turk, D.,Karshikov, A. The refined 1.9-A X-ray crystal structure of D-Phe-Pro-Arg chloromethylketone-inhibited human alpha-thrombin: structure analysis, overall structure, electrostatic properties, detailed active-site geometry, and structure-function relationships. Protein Sci., 1:426-471, 1992 Cited by PubMed: 1304349PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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