1AIX

HUMAN ALPHA-THROMBIN TERNARY COMPLEX WITH EXOSITE INHIBITOR HIRUGEN AND ACTIVE SITE INHIBITOR PHCH2OCO-D-DPA-PRO-BOROVAL

Summary for 1AIX

Entry DOI	10.2210/pdb1aix/pdb
Descriptor	ALPHA-THROMBIN (SMALL SUBUNIT), ALPHA-THROMBIN (LARGE SUBUNIT), HIRUGEN, ... (5 entities in total)
Functional Keywords	serine proteinase, blood coagulation, hydrolase-hydrolase inhibitor complex, blood coagulation-hydrolase inhibitor complex, blood coagulation/hydrolase inhibitor
Biological source	Homo sapiens (human) More
Cellular location	Secreted, extracellular space: P00734 P00734 Secreted: P28510
Total number of polymer chains	3
Total formula weight	36050.81
Authors	Skordalakes, E.,Dodson, G.,Elgendy, S.,Goodwin, C.A.,Green, D.,Tyrrel, R.,Scully, M.F.,Freyssinet, J.,Kakkar, V.V.,Deadman, J. (deposition date: 1997-04-30, release date: 1997-10-15, Last modification date: 2013-03-13)
Primary citation	Bode, W.,Turk, D.,Karshikov, A. The refined 1.9-A X-ray crystal structure of D-Phe-Pro-Arg chloromethylketone-inhibited human alpha-thrombin: structure analysis, overall structure, electrostatic properties, detailed active-site geometry, and structure-function relationships. Protein Sci., 1:426-471, 1992 Cited by PubMed: 1304349 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation