8B9D
| Human replisome bound by Pol Alpha | Descriptor: | Cell division control protein 45 homolog, Claspin, DNA Molecule, ... | Authors: | Jones, M.L, Yeeles, J.T.P. | Deposit date: | 2022-10-05 | Release date: | 2023-08-09 | Last modified: | 2023-08-30 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | How Pol alpha-primase is targeted to replisomes to prime eukaryotic DNA replication. Mol.Cell, 83, 2023
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8B9C
| S. cerevisiae pol alpha - replisome complex | Descriptor: | Cell division control protein 45, Chromosome segregation in meiosis protein 3, DNA polymerase alpha catalytic subunit A, ... | Authors: | Jones, M.L, Yeeles, J.T.P. | Deposit date: | 2022-10-05 | Release date: | 2023-08-09 | Last modified: | 2023-08-30 | Method: | ELECTRON MICROSCOPY (4.6 Å) | Cite: | How Pol alpha-primase is targeted to replisomes to prime eukaryotic DNA replication. Mol.Cell, 83, 2023
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8B9B
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8B9A
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1Z3N
| Human aldose reductase in complex with NADP+ and the inhibitor lidorestat at 1.04 angstrom | Descriptor: | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, aldose reductase, {3-[(4,5,7-TRIFLUORO-1,3-BENZOTHIAZOL-2-YL)METHYL]-1H-INDOL-1-YL}ACETIC ACID | Authors: | Van Zandt, M.C, Jones, M.L, Gunn, D.E, Geraci, L.S, Jones, J.H, Sawicki, D.R, Sredy, J, Jacot, J.L, Dicioccio, A.T, Petrova, T, Mitschler, A, Podjarny, A.D. | Deposit date: | 2005-03-14 | Release date: | 2006-03-14 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.04 Å) | Cite: | Discovery of 3-[(4,5,7-trifluorobenzothiazol-2-yl)methyl]indole-N-acetic acid (lidorestat) and congeners as highly potent and selective inhibitors of aldose reductase for treatment of chronic diabetic complications J.Med.Chem., 48, 2005
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7PFO
| Core human replisome | Descriptor: | Cell division control protein 45 homolog, Claspin, DNA polymerase epsilon catalytic subunit A, ... | Authors: | Jones, M.J, Yeeles, J.T.P. | Deposit date: | 2021-08-11 | Release date: | 2021-11-10 | Last modified: | 2023-10-18 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structure of a human replisome shows the organisation and interactions of a DNA replication machine. Embo J., 40, 2021
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6SXB
| XPF-ERCC1 Cryo-EM Structure, DNA-Bound form | Descriptor: | DNA (5'-D(*TP*CP*AP*GP*CP*AP*TP*CP*TP*G)-3'), DNA (5'-D(P*CP*AP*GP*AP*TP*GP*CP*TP*GP*A)-3'), DNA excision repair protein ERCC-1, ... | Authors: | Jones, M.L, Briggs, D.C, McDonald, N.Q. | Deposit date: | 2019-09-25 | Release date: | 2020-03-11 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (7.9 Å) | Cite: | Cryo-EM structures of the XPF-ERCC1 endonuclease reveal how DNA-junction engagement disrupts an auto-inhibited conformation. Nat Commun, 11, 2020
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6SXA
| XPF-ERCC1 Cryo-EM Structure, Apo-form | Descriptor: | DNA excision repair protein ERCC-1, DNA repair endonuclease XPF | Authors: | Jones, M.L, Briggs, D.C, McDonald, N.Q. | Deposit date: | 2019-09-25 | Release date: | 2020-03-11 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Cryo-EM structures of the XPF-ERCC1 endonuclease reveal how DNA-junction engagement disrupts an auto-inhibited conformation. Nat Commun, 11, 2020
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7PLO
| H. sapiens replisome-CUL2/LRR1 complex | Descriptor: | Cell division control protein 45 homolog, Claspin, Cullin-2, ... | Authors: | Jones, M.J, Yeeles, J.T.P, Deegan, T.D, Jenkyn-Bedford, M. | Deposit date: | 2021-09-01 | Release date: | 2021-11-10 | Last modified: | 2023-10-18 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | A conserved mechanism for regulating replisome disassembly in eukaryotes. Nature, 600, 2021
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7PMK
| S. cerevisiae replisome-SCF(Dia2) complex bound to double-stranded DNA (conformation I) | Descriptor: | Cell division control protein 45,Cell division control protein 45, Chromosome segregation in meiosis protein 3, DNA helicase, ... | Authors: | Jenkyn-Bedford, M, Yeeles, J.T.P, Deegan, T.D. | Deposit date: | 2021-09-02 | Release date: | 2021-11-10 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | A conserved mechanism for regulating replisome disassembly in eukaryotes. Nature, 600, 2021
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7PMN
| S. cerevisiae replisome-SCF(Dia2) complex bound to double-stranded DNA (conformation II) | Descriptor: | Cell division control protein 45,Cell division control protein 45, Chromosome segregation in meiosis protein 3, DNA polymerase alpha-binding protein, ... | Authors: | Jenkyn-Bedford, M, Yeeles, J.T.P, Deegan, T.D. | Deposit date: | 2021-09-02 | Release date: | 2021-11-10 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | A conserved mechanism for regulating replisome disassembly in eukaryotes. Nature, 600, 2021
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4I01
| Structure of the mutant Catabolite gen activator protein V140L | Descriptor: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Catabolite gene activator | Authors: | Pohl, E, Townsend, P.D, Rodgers, T, Burnell, D, McLeish, T.C.B, Wilson, M.R, Cann, M.J. | Deposit date: | 2012-11-16 | Release date: | 2013-10-30 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Modulation of global low-frequency motions underlies allosteric regulation: demonstration in CRP/FNR family transcription factors. Plos Biol., 11, 2013
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4I0A
| structure of the mutant Catabolite gene activator protein V132A | Descriptor: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Catabolite gene activator, GLYCEROL | Authors: | Pohl, E, Townsend, P.D, Rodgers, T, Burnell, D, McLeish, T.C.B, Wilson, M.R, Cann, M.J. | Deposit date: | 2012-11-16 | Release date: | 2013-10-30 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Modulation of global low-frequency motions underlies allosteric regulation: demonstration in CRP/FNR family transcription factors. Plos Biol., 11, 2013
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4I09
| structure of the mutant Catabolite gene activator protein V132L | Descriptor: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Catabolite gene activator | Authors: | Pohl, E, Townsend, P.D, Rodgers, T, Burnell, D, McLeish, T.C.B, Wilson, M.R, Cann, M.J. | Deposit date: | 2012-11-16 | Release date: | 2013-10-30 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Modulation of global low-frequency motions underlies allosteric regulation: demonstration in CRP/FNR family transcription factors. Plos Biol., 11, 2013
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4HZF
| structure of the wild type Catabolite gene Activator Protein | Descriptor: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Catabolite gene activator, GLYCEROL, ... | Authors: | Pohl, E, Townsend, P.D, Rodgers, T, Burnell, D, McLeish, T.C.B, Wilson, M.R, Cann, M. | Deposit date: | 2012-11-15 | Release date: | 2013-10-30 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.48 Å) | Cite: | Modulation of global low-frequency motions underlies allosteric regulation: demonstration in CRP/FNR family transcription factors. Plos Biol., 11, 2013
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4I02
| structure of the mutant Catabolite gene activator protein V140A | Descriptor: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Catabolite gene activator | Authors: | Pohl, E, Townsend, P.D, Rodgers, T, Burnell, D, McLeish, T.C.B, Wilson, M.R, Cann, M.J. | Deposit date: | 2012-11-16 | Release date: | 2013-10-30 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Modulation of global low-frequency motions underlies allosteric regulation: demonstration in CRP/FNR family transcription factors. Plos Biol., 11, 2013
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4I0B
| structure of the mutant Catabolite gene activator protein H160L | Descriptor: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Catabolite gene activator | Authors: | Pohl, E, Townsend, P.D, Rodgers, T, Burnell, D, McLeish, T.C.B, Wilson, M.R, Cann, M.J. | Deposit date: | 2012-11-16 | Release date: | 2013-10-30 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Modulation of global low-frequency motions underlies allosteric regulation: demonstration in CRP/FNR family transcription factors. Plos Biol., 11, 2013
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1AOE
| CANDIDA ALBICANS DIHYDROFOLATE REDUCTASE COMPLEXED WITH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE (NADPH) AND 1,3-DIAMINO-7-(1-ETHYEPROPYE)-7H-PYRRALO-[3,2-F]QUINAZOLINE (GW345) | Descriptor: | 7-(1-ETHYL-PROPYL)-7H-PYRROLO-[3,2-F]QUINAZOLINE-1,3-DIAMINE, DIHYDROFOLATE REDUCTASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Whitlow, M, Howard, A.J, Stewart, D. | Deposit date: | 1997-07-02 | Release date: | 1998-01-07 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | X-ray crystallographic studies of Candida albicans dihydrofolate reductase. High resolution structures of the holoenzyme and an inhibited ternary complex. J.Biol.Chem., 272, 1997
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