1Z3N

Human aldose reductase in complex with NADP+ and the inhibitor lidorestat at 1.04 angstrom

Summary for 1Z3N

Entry DOI	10.2210/pdb1z3n/pdb
Related	1US0
Descriptor	aldose reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, {3-[(4,5,7-TRIFLUORO-1,3-BENZOTHIAZOL-2-YL)METHYL]-1H-INDOL-1-YL}ACETIC ACID, ... (4 entities in total)
Functional Keywords	oxidoreductase, nadp+, lidorestat
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	37302.39
Authors	Van Zandt, M.C.,Jones, M.L.,Gunn, D.E.,Geraci, L.S.,Jones, J.H.,Sawicki, D.R.,Sredy, J.,Jacot, J.L.,Dicioccio, A.T.,Petrova, T.,Mitschler, A.,Podjarny, A.D. (deposition date: 2005-03-14, release date: 2006-03-14, Last modification date: 2024-03-13)
Primary citation	Van Zandt, M.C.,Jones, M.L.,Gunn, D.E.,Geraci, L.S.,Jones, J.H.,Sawicki, D.R.,Sredy, J.,Jacot, J.L.,Dicioccio, A.T.,Petrova, T.,Mitschler, A.,Podjarny, A.D. Discovery of 3-[(4,5,7-trifluorobenzothiazol-2-yl)methyl]indole-N-acetic acid (lidorestat) and congeners as highly potent and selective inhibitors of aldose reductase for treatment of chronic diabetic complications J.Med.Chem., 48:3141-3152, 2005 Cited by PubMed: 15857120 DOI: 10.1021/jm0492094 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.04 Å)

Structure validation