1Z3N
Human aldose reductase in complex with NADP+ and the inhibitor lidorestat at 1.04 angstrom
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | aldose reductase | polymer | 319 | 36180.6 | 1 | GenBank (178489) Pfam (PF00248) UniProt (by SIFTS) (P15121) In PDB | Homo sapiens (human) | |
| 2 | A | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 1 | Chemie (NDP) | |||
| 3 | A | {3-[(4,5,7-TRIFLUORO-1,3-BENZOTHIAZOL-2-YL)METHYL]-1H-INDOL-1-YL}ACETIC ACID | non-polymer | 376.4 | 1 | Chemie (3NA) | |||
| 4 | water | water | 18.0 | 397 | Chemie (HOH) |
Sequence modifications
A: 0 - 315 (GenBank: 178489)
| PDB | External Database | Details |
|---|---|---|
| Gly -3 | - | expression tag |
| Ser -2 | - | expression tag |
| His -1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 36180.6 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1121.8 | |
| All* | Total formula weight | 37302.4 |
