1AOE

CANDIDA ALBICANS DIHYDROFOLATE REDUCTASE COMPLEXED WITH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE (NADPH) AND 1,3-DIAMINO-7-(1-ETHYEPROPYE)-7H-PYRRALO-[3,2-F]QUINAZOLINE (GW345)

Summary for 1AOE

Entry DOI	10.2210/pdb1aoe/pdb
Descriptor	DIHYDROFOLATE REDUCTASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 7-(1-ETHYL-PROPYL)-7H-PYRROLO-[3,2-F]QUINAZOLINE-1,3-DIAMINE, ... (4 entities in total)
Functional Keywords	oxidoreductase, antifungal target, reductase
Biological source	Candida albicans
Total number of polymer chains	2
Total formula weight	46418.59
Authors	Whitlow, M.,Howard, A.J.,Stewart, D. (deposition date: 1997-07-02, release date: 1998-01-07, Last modification date: 2023-08-02)
Primary citation	Whitlow, M.,Howard, A.J.,Stewart, D.,Hardman, K.D.,Kuyper, L.F.,Baccanari, D.P.,Fling, M.E.,Tansik, R.L. X-ray crystallographic studies of Candida albicans dihydrofolate reductase. High resolution structures of the holoenzyme and an inhibited ternary complex. J.Biol.Chem., 272:30289-30298, 1997 Cited by PubMed: 9374515 DOI: 10.1074/jbc.272.48.30289 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation