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6C6K
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BU of 6c6k by Molmil
Structural basis for preferential recognition of cap 0 RNA by a human IFIT1-IFIT3 protein complex
Descriptor: Interferon-induced protein with tetratricopeptide repeats 1, Interferon-induced protein with tetratricopeptide repeats 3, MAGNESIUM ION, ...
Authors:Amarasinghe, G.K, Leung, D.W, Johnson, B, Xu, W.
Deposit date:2018-01-18
Release date:2018-04-04
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.54 Å)
Cite:Human IFIT3 Modulates IFIT1 RNA Binding Specificity and Protein Stability.
Immunity, 48, 2018
5V19
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BU of 5v19 by Molmil
Structure-based drug design of novel ASK1 inhibitors using a fully integrated lead optimization strategy
Descriptor: Mitogen-activated protein kinase kinase kinase 5, N-(1-ethyl-1H-pyrazol-4-yl)furan-3-carboxamide
Authors:Dougan, D.R, Lawson, J.D, Lane, W.
Deposit date:2017-03-01
Release date:2017-03-29
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structure-based drug design of novel ASK1 inhibitors using an integrated lead optimization strategy.
Bioorg. Med. Chem. Lett., 27, 2017
5W0X
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BU of 5w0x by Molmil
Crystal structure of mouse TOR signaling pathway regulator-like (TIPRL) delta 94-103
Descriptor: TIP41-like protein
Authors:Wu, C, Zheng, A, Li, J, Satyshur, K, Xing, Y.
Deposit date:2017-06-01
Release date:2018-01-17
Last modified:2020-01-01
Method:X-RAY DIFFRACTION (2.717 Å)
Cite:Methylation-regulated decommissioning of multimeric PP2A complexes.
Nat Commun, 8, 2017
5W0W
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BU of 5w0w by Molmil
Crystal structure of Protein Phosphatase 2A bound to TIPRL
Descriptor: MANGANESE (II) ION, Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform, ...
Authors:Wu, C, Zheng, A, Li, J, Satyshur, K, Xing, Y.
Deposit date:2017-06-01
Release date:2018-01-17
Last modified:2020-01-01
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:Methylation-regulated decommissioning of multimeric PP2A complexes.
Nat Commun, 8, 2017
6XIH
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BU of 6xih by Molmil
Structure-guided optimization of a novel class of ASK1 inhibitors with increased sp3 character and an exquisite selectivity profile
Descriptor: (2R)-N-{6-[4-(propan-2-yl)-4H-1,2,4-triazol-3-yl]pyridin-2-yl}oxane-2-carboxamide, Mitogen-activated protein kinase kinase kinase 5
Authors:Dougan, D.R.
Deposit date:2020-06-19
Release date:2020-08-12
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structure-guided optimization of a novel class of ASK1 inhibitors with increased sp3character and an exquisite selectivity profile.
Bioorg.Med.Chem.Lett., 30, 2020
6C54
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BU of 6c54 by Molmil
Ebola nucleoprotein nucleocapsid-like assembly and the asymmetric unit
Descriptor: Nucleoprotein
Authors:Su, Z, Wu, C, Pintilie, G.D, Chiu, W, Amarasinghe, G.K, Leung, D.W.
Deposit date:2018-01-13
Release date:2018-03-07
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (5.8 Å)
Cite:Electron Cryo-microscopy Structure of Ebola Virus Nucleoprotein Reveals a Mechanism for Nucleocapsid-like Assembly.
Cell, 172, 2018
4M0Q
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BU of 4m0q by Molmil
Ebola virus VP24 structure
Descriptor: Membrane-associated protein VP24
Authors:Xu, W, Leung, D.W, Borek, D, Amarasinghe, G.K.
Deposit date:2013-08-01
Release date:2014-03-19
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.921 Å)
Cite:The Marburg Virus VP24 Protein Interacts with Keap1 to Activate the Cytoprotective Antioxidant Response Pathway.
Cell Rep, 6, 2014
7UAQ
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BU of 7uaq by Molmil
Structure of the SARS-CoV-2 NTD in complex with C1520, local refinement
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, C1520 Fab Heavy Chain, ...
Authors:Barnes, C.O.
Deposit date:2022-03-13
Release date:2022-04-27
Last modified:2022-06-22
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Analysis of memory B cells identifies conserved neutralizing epitopes on the N-terminal domain of variant SARS-Cov-2 spike proteins.
Immunity, 55, 2022
7UAP
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BU of 7uap by Molmil
Structure of the SARS-CoV-2 S 6P trimer in complex with the neutralizing antibody Fab fragment, C1520
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, C1520 Fab Heavy Chain, ...
Authors:Barnes, C.O.
Deposit date:2022-03-13
Release date:2022-04-27
Last modified:2022-06-22
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Analysis of memory B cells identifies conserved neutralizing epitopes on the N-terminal domain of variant SARS-Cov-2 spike proteins.
Immunity, 55, 2022
7UAR
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BU of 7uar by Molmil
Structure of the SARS-CoV-2 S 6P trimer in complex with the neutralizing antibody Fab fragment, C1717
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, C1717 Fab Heavy Chain, ...
Authors:Barnes, C.O.
Deposit date:2022-03-13
Release date:2022-04-27
Last modified:2022-06-22
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Analysis of memory B cells identifies conserved neutralizing epitopes on the N-terminal domain of variant SARS-Cov-2 spike proteins.
Immunity, 55, 2022
2QE5
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BU of 2qe5 by Molmil
Structure of HCV NS5B Bound to an Anthranilic Acid Inhibitor
Descriptor: 2-{[(4-CHLOROPHENOXY)ACETYL]AMINO}BENZOIC ACID, RNA-directed RNA polymerase
Authors:Chopra, R, Svenson, K, Bard, J.
Deposit date:2007-06-22
Release date:2007-10-02
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Identification of Anthranilic Acid Derivatives as a Novel Class of Allosteric Inhibitors of Hepatitis C NS5B Polymerase
J.Med.Chem., 50, 2007
2QE2
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BU of 2qe2 by Molmil
Structure of HCV NS5B Bound to an Anthranilic Acid Inhibitor
Descriptor: 2-{[N-(2-ACETYL-5-CHLORO-4-FLUOROPHENYL)GLYCYL]AMINO}BENZOIC ACID, RNA-directed RNA polymerase
Authors:Chopra, R, Svenson, K, Bard, J.
Deposit date:2007-06-22
Release date:2007-10-02
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Identification of Anthranilic Acid Derivatives as a Novel Class of Allosteric Inhibitors of Hepatitis C NS5B Polymerase
J.Med.Chem., 50, 2007
5V24
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BU of 5v24 by Molmil
Structure-based drug design of novel ASK1 inhibitors using a fully integrated lead optimization strategy
Descriptor: 2-[4-(propan-2-yl)-4H-1,2,4-triazol-3-yl]-N-(pyridin-2-yl)-1,3-thiazole-4-carboxamide, Mitogen-activated protein kinase kinase kinase 5
Authors:Dougan, D.R, Lawson, J.D.
Deposit date:2017-03-02
Release date:2017-03-29
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure-based drug design of novel ASK1 inhibitors using an integrated lead optimization strategy.
Bioorg. Med. Chem. Lett., 27, 2017

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