Structure of HCV NS5B Bound to an Anthranilic Acid Inhibitor

Summary for 2QE2

DescriptorRNA-directed RNA polymerase, 2-{[N-(2-ACETYL-5-CHLORO-4-FLUOROPHENYL)GLYCYL]AMINO}BENZOIC ACID (2 entities in total)
Functional Keywordstransferase
Biological sourceHepatitis C virus subtype 1b
Total number of polymer chains2
Total molecular weight129224.71
Chopra, R.,Svenson, K.,Bard, J. (deposition date: 2007-06-22, release date: 2007-10-02, Last modification date: 2011-07-13)
Primary citation
Nittoli, T.,Curran, K.,Insaf, S.,DiGrandi, M.,Orlowski, M.,Chopra, R.,Agarwal, A.,Howe, A.Y.M.,Prashad, A.,Brawner Floyd, M.,Johnson, B.,Sutherland, A.,Wheless, K.,Feld, B.,O'Connell, J.,Mansour, T.S.,Bloom, J.
Identification of Anthranilic Acid Derivatives as a Novel Class of Allosteric Inhibitors of Hepatitis C NS5B Polymerase
J.Med.Chem., 50:2108-2116, 2007
PubMed: 17402724 (PDB entries with the same primary citation)
DOI: 10.1021/jm061428x
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.290240.7%4.8%3.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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