2QE5

Structure of HCV NS5B Bound to an Anthranilic Acid Inhibitor

Summary for 2QE5

Entry DOI	10.2210/pdb2qe5/pdb
Related	2QE2
Descriptor	RNA-directed RNA polymerase, 2-{[(4-CHLOROPHENOXY)ACETYL]AMINO}BENZOIC ACID (3 entities in total)
Functional Keywords	transferase polymerase, transferase
Biological source	Hepatitis C virus subtype 1b
Total number of polymer chains	4
Total formula weight	257296.10
Authors	Chopra, R.,Svenson, K.,Bard, J. (deposition date: 2007-06-22, release date: 2007-10-02, Last modification date: 2023-08-30)
Primary citation	Nittoli, T.,Curran, K.,Insaf, S.,DiGrandi, M.,Orlowski, M.,Chopra, R.,Agarwal, A.,Howe, A.Y.M.,Prashad, A.,Floyd, M.B.,Johnson, B.,Sutherland, A.,Wheless, K.,Feld, B.,O'Connell, J.,Mansour, T.S.,Bloom, J. Identification of Anthranilic Acid Derivatives as a Novel Class of Allosteric Inhibitors of Hepatitis C NS5B Polymerase J.Med.Chem., 50:2108-2116, 2007 Cited by PubMed: 17402724 DOI: 10.1021/jm061428x PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation