Structure of HCV NS5B Bound to an Anthranilic Acid Inhibitor

Summary for 2QE5

DescriptorRNA-directed RNA polymerase, 2-{[(4-CHLOROPHENOXY)ACETYL]AMINO}BENZOIC ACID (3 entities in total)
Functional Keywordstransferase polymerase, transferase
Biological sourceHepatitis C virus subtype 1b
Total number of polymer chains4
Total molecular weight257296.11
Chopra, R.,Svenson, K.,Bard, J. (deposition date: 2007-06-22, release date: 2007-10-02, Last modification date: 2011-07-13)
Primary citation
Nittoli, T.,Curran, K.,Insaf, S.,DiGrandi, M.,Orlowski, M.,Chopra, R.,Agarwal, A.,Howe, A.Y.M.,Prashad, A.,Floyd, M.B.,Johnson, B.,Sutherland, A.,Wheless, K.,Feld, B.,O'Connell, J.,Mansour, T.S.,Bloom, J.
Identification of Anthranilic Acid Derivatives as a Novel Class of Allosteric Inhibitors of Hepatitis C NS5B Polymerase
J.Med.Chem., 50:2108-2116, 2007
PubMed: 17402724 (PDB entries with the same primary citation)
DOI: 10.1021/jm061428x
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.225181.6%9.3%6.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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