1W3B
 
 | | The superhelical TPR domain of O-linked GlcNAc transferase reveals structural similarities to importin alpha. | | Descriptor: | CALCIUM ION, UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE 110 | | Authors: | Jinek, M, Rehwinkel, J, Lazarus, B.D, Izaurralde, E, Hanover, J.A, Conti, E. | | Deposit date: | 2004-07-14 | | Release date: | 2004-09-09 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.85 Å) | | Cite: | The Superhelical Tpr-Repeat Domain of O-Linked Glcnac Transferase Exhibits Structural Similarities to Importin Alpha
Nat.Struct.Mol.Biol., 11, 2004
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2J0B
 | | Structure of the catalytic domain of mouse Manic Fringe in complex with UDP and manganese | | Descriptor: | BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE MANIC FRINGE, MANGANESE (II) ION, POTASSIUM ION, ... | | Authors: | Jinek, M, Chen, Y.-W, Clausen, H, Cohen, S.M, Conti, E. | | Deposit date: | 2006-08-01 | | Release date: | 2006-09-04 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structural Insights Into the Notch-Modifying Glycosyltransferase Fringe
Nat.Struct.Mol.Biol., 13, 2006
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2J0A
 | | Structure of the catalytic domain of mouse Manic Fringe | | Descriptor: | BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE MANIC FRINGE, POTASSIUM ION, SULFATE ION | | Authors: | Jinek, M, Chen, Y.-W, Clausen, H, Cohen, S.M, Conti, E. | | Deposit date: | 2006-08-01 | | Release date: | 2006-09-04 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structural Insights Into the Notch-Modifying Glycosyltransferase Fringe
Nat.Struct.Mol.Biol., 13, 2006
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4CMP
 | | Crystal structure of S. pyogenes Cas9 | | Descriptor: | CRISPR-ASSOCIATED ENDONUCLEASE CAS9/CSN1, MAGNESIUM ION, SULFATE ION | | Authors: | Jinek, M, Jiang, F, Taylor, D.W, Sternberg, S.H, Kaya, E, Ma, E, Anders, C, Hauer, M, Zhou, K, Lin, S, Kaplan, M, Iavarone, A.T, Charpentier, E, Nogales, E, Doudna, J.A. | | Deposit date: | 2014-01-16 | | Release date: | 2014-02-12 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.62 Å) | | Cite: | Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation.
Science, 343, 2014
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4CMQ
 | | Crystal structure of Mn-bound S.pyogenes Cas9 | | Descriptor: | CRISPR-ASSOCIATED ENDONUCLEASE CAS9/CSN1, MANGANESE (II) ION, SULFATE ION | | Authors: | Jinek, M, Jiang, F, Taylor, D.W, Sternberg, S.H, Kaya, E, Ma, E, Anders, C, Hauer, M, Zhou, K, Lin, S, Kaplan, M, Iavarone, A.T, Charpentier, E, Nogales, E, Doudna, J.A. | | Deposit date: | 2014-01-17 | | Release date: | 2014-02-12 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (3.09 Å) | | Cite: | Structures of Cas9 Endonucleases Reveal RNA- Mediated Conformational Activation
Science, 343, 2014
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2VXG
 | | Crystal structure of the conserved C-terminal region of Ge-1 | | Descriptor: | CG6181-PA, ISOFORM A | | Authors: | Jinek, M, Eulalio, A, Lingel, A, Helms, S, Conti, E, Izaurralde, E. | | Deposit date: | 2008-07-04 | | Release date: | 2008-09-09 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | The C-Terminal Region of Ge-1 Presents Conserved Structural Features Required for P-Body Localization.
RNA, 14, 2008
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2X04
 | | Crystal structure of the PABC-TNRC6C complex | | Descriptor: | POLYADENYLATE-BINDING PROTEIN 1, SULFATE ION, TRINUCLEOTIDE REPEAT-CONTAINING GENE 6C PROTEIN | | Authors: | Jinek, M, Fabian, M.R, Coyle, S.M, Sonenberg, N, Doudna, J.A. | | Deposit date: | 2009-12-04 | | Release date: | 2010-01-19 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.49 Å) | | Cite: | Structural Insights Into the Human Gw182-Pabc Interaction in Microrna-Mediated Deadenylation
Nat.Struct.Mol.Biol., 17, 2010
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2Y35
 | | Crystal structure of Xrn1-substrate complex | | Descriptor: | DT11 (5'-D(*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP)-3', LD22664P, MAGNESIUM ION | | Authors: | Jinek, M, Coyle, S.M, Doudna, J.A. | | Deposit date: | 2010-12-18 | | Release date: | 2011-03-16 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Coupled 5' Nucleotide Recognition and Processivity in Xrn1-Mediated Mrna Decay.
Mol.Cell, 41, 2011
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6I1K
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6F9S
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6FDL
 | | Crystal structure of the NYN domain of human MARF1 | | Descriptor: | Meiosis regulator and mRNA stability factor 1 | | Authors: | Jinek, M, Brandmann, T. | | Deposit date: | 2017-12-26 | | Release date: | 2018-11-07 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Human MARF1 is an endoribonuclease that interacts with the DCP1:2 decapping complex and degrades target mRNAs.
Nucleic Acids Res., 46, 2018
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6I1L
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4C8Y
 | | Cas6 (TTHA0078) substrate mimic complex | | Descriptor: | CRISPR-associated protein Cas6 C-terminal domain-containing protein, R1 REPEAT RNA SUBSTRATE MIMIC, SULFATE ION | | Authors: | Jinek, M, Niewoehner, O, Doudna, J.A. | | Deposit date: | 2013-10-02 | | Release date: | 2013-11-06 | | Last modified: | 2025-11-12 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Evolution of Crispr RNA Recognition and Processing by Cas6 Endonucleases.
Nucleic Acids Res., 42, 2014
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4C97
 | | Cas6 (TTHA0078) H37A mutant | | Descriptor: | CAS6A, SULFATE ION | | Authors: | Jinek, M, Niewoehner, O, Doudna, J.A. | | Deposit date: | 2013-10-02 | | Release date: | 2013-11-06 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Evolution of Crispr RNA Recognition and Processing by Cas6 Endonucleases.
Nucleic Acids Res., 42, 2014
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4C9D
 | | Cas6 (TTHB231) product complex | | Descriptor: | CAS6B, R3 REPEAT RNA CLEAVAGE PRODUCT | | Authors: | Jinek, M, Niewoehner, O, Doudna, J.A. | | Deposit date: | 2013-10-02 | | Release date: | 2013-11-06 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Evolution of CRISPR RNA recognition and processing by Cas6 endonucleases.
Nucleic Acids Res., 42, 2014
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4C8Z
 | | Cas6 (TTHA0078) product complex | | Descriptor: | CAS6A, POTASSIUM ION, R1 REPEAT RNA CLEAVAGE PRODUCT, ... | | Authors: | Jinek, M, Niewoehner, O, Doudna, J.A. | | Deposit date: | 2013-10-02 | | Release date: | 2013-11-06 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.503 Å) | | Cite: | Evolution of Crispr RNA Recognition and Processing by Cas6 Endonucleases.
Nucleic Acids Res., 42, 2014
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4C98
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6FUW
 | | Cryo-EM structure of the human CPSF160-WDR33-CPSF30 complex bound to the PAS AAUAAA motif at 3.1 Angstrom resolution | | Descriptor: | Cleavage and polyadenylation specificity factor subunit 1, Cleavage and polyadenylation specificity factor subunit 4, RNA (5'-R(P*AP*AP*UP*AP*AP*AP*GP*G)-3'), ... | | Authors: | Clerici, M, Faini, M, Jinek, M. | | Deposit date: | 2018-02-28 | | Release date: | 2018-03-21 | | Last modified: | 2024-07-10 | | Method: | ELECTRON MICROSCOPY (3.07 Å) | | Cite: | Structural basis of AAUAAA polyadenylation signal recognition by the human CPSF complex.
Nat. Struct. Mol. Biol., 25, 2018
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8R3Z
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9EZX
 | | Vibrio cholerae DdmD apo complex | | Descriptor: | Helicase/UvrB N-terminal domain-containing protein | | Authors: | Loeff, L, Jinek, M. | | Deposit date: | 2024-04-14 | | Release date: | 2024-06-19 | | Last modified: | 2024-07-24 | | Method: | ELECTRON MICROSCOPY (2.55 Å) | | Cite: | Molecular mechanism of plasmid elimination by the DdmDE defense system.
Science, 385, 2024
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9EZY
 | | Vibrio cholerae DdmD-DdmE holo complex | | Descriptor: | 14 nucleotide DNA guide with terminal 5' phosphate, Helicase/UvrB N-terminal domain-containing protein, MAGNESIUM ION, ... | | Authors: | Loeff, L, Jinek, M. | | Deposit date: | 2024-04-14 | | Release date: | 2024-09-04 | | Method: | ELECTRON MICROSCOPY (2.56 Å) | | Cite: | Molecular mechanism of plasmid elimination by the DdmDE defense system.
Science, 385, 2024
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3ICQ
 | | Karyopherin nuclear state | | Descriptor: | Exportin-T, GTP-binding nuclear protein GSP1/CNR1, GUANOSINE-5'-TRIPHOSPHATE, ... | | Authors: | Cook, A.G, Fukuhara, N, Jinek, M, Conti, E. | | Deposit date: | 2009-07-18 | | Release date: | 2009-08-25 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Structures of the tRNA export factor in the nuclear and cytosolic states
Nature, 461, 2009
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3IBV
 | | Karyopherin cytosolic state | | Descriptor: | CALCIUM ION, Exportin-T | | Authors: | Cook, A.G, Fukuhara, N, Jinek, M, Conti, E. | | Deposit date: | 2009-07-17 | | Release date: | 2009-08-25 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Structures of the tRNA export factor in the nuclear and cytosolic states
Nature, 461, 2009
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6O16
 | | Crystal structure of murine DHX37 in complex with RNA | | Descriptor: | DEAH (Asp-Glu-Ala-His) box polypeptide 37, RNA (5'-R(*UP*UP*UP*UP*UP*UP*UP*UP*UP*U)-3') | | Authors: | Boneberg, F, Brandmann, T, Kobel, L, van den Heuvel, J, Bargsten, K, Bammert, L, Kutay, U, Jinek, M. | | Deposit date: | 2019-02-18 | | Release date: | 2019-04-17 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.875 Å) | | Cite: | Molecular mechanism of the RNA helicase DHX37 and its activation by UTP14A in ribosome biogenesis.
Rna, 25, 2019
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8BD5
 | | Cas12k-sgRNA-dsDNA-S15-TniQ-TnsC transposon recruitment complex | | Descriptor: | 30S ribosomal protein S15, ADENOSINE-5'-TRIPHOSPHATE, DNA non-target strand, ... | | Authors: | Schmitz, M, Querques, I, Oberli, S, Chanez, C, Jinek, M. | | Deposit date: | 2022-10-18 | | Release date: | 2022-12-28 | | Last modified: | 2024-07-24 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Structural basis for the assembly of the type V CRISPR-associated transposon complex.
Cell, 185, 2022
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