2ZCQ
 
 | | Crystal structure of the C(30) carotenoid dehydrosqualene synthase from Staphylococcus aureus complexed with bisphosphonate BPH-652 | | 分子名称: | (1R)-4-(3-phenoxyphenyl)-1-phosphonobutane-1-sulfonic acid, Dehydrosqualene synthase, MAGNESIUM ION | | 著者 | Liu, C.I, Jeng, W.Y, Wang, A.H, Oldfield, E. | | 登録日 | 2007-11-11 | | 公開日 | 2008-03-11 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.38 Å) | | 主引用文献 | A cholesterol biosynthesis inhibitor blocks Staphylococcus aureus virulence.
Science, 319, 2008
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2ZCR
 | | Crystal structure of the C(30) carotenoid dehydrosqualene synthase from Staphylococcus aureus complexed with bisphosphonate BPH-698 | | 分子名称: | Dehydrosqualene synthase, MAGNESIUM ION, tripotassium (1R)-4-(4'-butylbiphenyl-4-yl)-1-phosphonatobutane-1-sulfonate | | 著者 | Liu, C.I, Jeng, W.Y, Wang, A.H, Oldfield, E. | | 登録日 | 2007-11-11 | | 公開日 | 2008-03-11 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.92 Å) | | 主引用文献 | A cholesterol biosynthesis inhibitor blocks Staphylococcus aureus virulence.
Science, 319, 2008
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2ZCO
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3A7I
 | | Human MST3 kinase in complex with adenine | | 分子名称: | ADENINE, Serine/threonine kinase 24 (STE20 homolog, yeast) | | 著者 | Ko, T.P, Jeng, W.Y, Liu, C.I, Lai, M.D, Wang, A.H.J. | | 登録日 | 2009-09-26 | | 公開日 | 2010-02-02 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | | 主引用文献 | Structures of human MST3 kinase in complex with adenine, ADP and Mn2+.
Acta Crystallogr.,Sect.D, 66, 2010
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3A7J
 | | Human MST3 kinase in complex with MnADP | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, MANGANESE (II) ION, Serine/threonine kinase 24 (STE20 homolog, ... | | 著者 | Ko, T.P, Jeng, W.Y, Liu, C.I, Lai, M.D, Wang, A.H.J. | | 登録日 | 2009-09-27 | | 公開日 | 2010-02-02 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Structures of human MST3 kinase in complex with adenine, ADP and Mn2+.
Acta Crystallogr.,Sect.D, 66, 2010
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3A7F
 | | Human MST3 kinase | | 分子名称: | Serine/threonine kinase 24 (STE20 homolog, yeast) | | 著者 | Ko, T.P, Jeng, W.Y, Liu, C.I, Lai, M.D, Wang, A.H.J. | | 登録日 | 2009-09-26 | | 公開日 | 2010-02-02 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | Structures of human MST3 kinase in complex with adenine, ADP and Mn2+.
Acta Crystallogr.,Sect.D, 66, 2010
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3A7H
 | | Human MST3 kinase in complex with ATP | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Serine/threonine kinase 24 (STE20 homolog, yeast) | | 著者 | Ko, T.P, Jeng, W.Y, Liu, C.I, Lai, M.D, Wang, A.H.J. | | 登録日 | 2009-09-26 | | 公開日 | 2010-02-02 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | | 主引用文献 | Structures of human MST3 kinase in complex with adenine, ADP and Mn2+.
Acta Crystallogr.,Sect.D, 66, 2010
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3A7G
 | | Human MST3 kinase | | 分子名称: | Serine/threonine kinase 24 (STE20 homolog, yeast) | | 著者 | Ko, T.P, Jeng, W.Y, Liu, C.I, Lai, M.D, Wang, A.H.J. | | 登録日 | 2009-09-26 | | 公開日 | 2010-02-02 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structures of human MST3 kinase in complex with adenine, ADP and Mn2+.
Acta Crystallogr.,Sect.D, 66, 2010
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3VJA
 | | Crystal structure of the human squalene synthase | | 分子名称: | NICKEL (II) ION, Squalene synthase | | 著者 | Liu, C.I, Jeng, W.Y, Chang, W.J, Wang, A.H.J. | | 登録日 | 2011-10-14 | | 公開日 | 2012-04-11 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | | 主引用文献 | Binding modes of zaragozic acid A to human squalene synthase and staphylococcal dehydrosqualene synthase
J.Biol.Chem., 287, 2012
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3VJB
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3VJC
 | | Crystal structure of the human squalene synthase in complex with zaragozic acid A | | 分子名称: | MAGNESIUM ION, PHOSPHATE ION, Squalene synthase, ... | | 著者 | Liu, C.I, Jeng, W.Y, Chang, W.J, Ko, T.P, Wang, A.H.J. | | 登録日 | 2011-10-14 | | 公開日 | 2012-04-11 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | | 主引用文献 | Binding modes of zaragozic acid A to human squalene synthase and staphylococcal dehydrosqualene synthase
J.Biol.Chem., 287, 2012
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3VJ9
 | | Crystal structure of the human squalene synthase | | 分子名称: | CALCIUM ION, NICKEL (II) ION, Squalene synthase | | 著者 | Liu, C.I, Jeng, W.Y, Chang, W.J, Wang, A.H.J. | | 登録日 | 2011-10-14 | | 公開日 | 2012-04-11 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.52 Å) | | 主引用文献 | Binding modes of zaragozic acid A to human squalene synthase and staphylococcal dehydrosqualene synthase
J.Biol.Chem., 287, 2012
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3VJ8
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3WEH
 | | Crystal structure of the human squalene synthase in complex with presqualene pyrophosphate | | 分子名称: | MAGNESIUM ION, Squalene synthase, {(1R,2R,3R)-2-[(3E)-4,8-dimethylnona-3,7-dien-1-yl]-2-methyl-3-[(1E,5E)-2,6,10-trimethylundeca-1,5,9-trien-1-yl]cyclopropyl}methyl trihydrogen diphosphate | | 著者 | Liu, C.I, Jeng, W.Y, Wang, A.H.J. | | 登録日 | 2013-07-07 | | 公開日 | 2014-02-12 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.87 Å) | | 主引用文献 | Structural insights into the catalytic mechanism of human squalene synthase.
Acta Crystallogr.,Sect.D, 70, 2014
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3WEI
 | | Crystal structure of the human squalene synthase Y73A mutant in complex with presqualene pyrophosphate | | 分子名称: | MANGANESE (II) ION, Squalene synthase, {(1R,2R,3R)-2-[(3E)-4,8-dimethylnona-3,7-dien-1-yl]-2-methyl-3-[(1E,5E)-2,6,10-trimethylundeca-1,5,9-trien-1-yl]cyclopropyl}methyl trihydrogen diphosphate | | 著者 | Liu, C.I, Jeng, W.Y, Wang, A.H.J. | | 登録日 | 2013-07-07 | | 公開日 | 2014-02-12 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | | 主引用文献 | Structural insights into the catalytic mechanism of human squalene synthase.
Acta Crystallogr.,Sect.D, 70, 2014
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3WEK
 | | Crystal structure of the human squalene synthase F288L mutant in complex with presqualene pyrophosphate | | 分子名称: | MAGNESIUM ION, Squalene synthase, {(1R,2R,3R)-2-[(3E)-4,8-dimethylnona-3,7-dien-1-yl]-2-methyl-3-[(1E,5E)-2,6,10-trimethylundeca-1,5,9-trien-1-yl]cyclopropyl}methyl trihydrogen diphosphate | | 著者 | Liu, C.I, Jeng, W.Y, Wang, A.H.J. | | 登録日 | 2013-07-07 | | 公開日 | 2014-02-12 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Structural insights into the catalytic mechanism of human squalene synthase.
Acta Crystallogr.,Sect.D, 70, 2014
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3WEF
 | | Crystal structure of the human squalene synthase in complex with farnesyl thiopyrophosphate | | 分子名称: | S-[(2E,6E)-3,7,11-TRIMETHYLDODECA-2,6,10-TRIENYL] TRIHYDROGEN THIODIPHOSPHATE, Squalene synthase | | 著者 | Liu, C.I, Jeng, W.Y, Wang, A.H.J. | | 登録日 | 2013-07-07 | | 公開日 | 2014-02-12 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | Structural insights into the catalytic mechanism of human squalene synthase.
Acta Crystallogr.,Sect.D, 70, 2014
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3W7F
 | | Crystal structure of the C(30) carotenoid dehydrosqualene synthase from staphylococcus aureus complexed with farnesyl thiopyrophosphate | | 分子名称: | Dehydrosqualene synthase, MAGNESIUM ION, S-[(2E,6E)-3,7,11-TRIMETHYLDODECA-2,6,10-TRIENYL] TRIHYDROGEN THIODIPHOSPHATE | | 著者 | Liu, C.I, Jeng, W.Y, Wang, A.H, Oldfield, E. | | 登録日 | 2013-02-28 | | 公開日 | 2013-04-10 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | A cholesterol biosynthesis inhibitor blocks Staphylococcus aureus virulence.
Science, 319, 2008
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3WH0
 | | Structure of Pin1 Complex with 18-crown-6 | | 分子名称: | 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, ... | | 著者 | Lee, C.C, Liu, C.I, Jeng, W.Y, Wang, A.H.J. | | 登録日 | 2013-08-20 | | 公開日 | 2014-10-15 | | 最終更新日 | 2022-08-24 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Crowning proteins: modulating the protein surface properties using crown ethers.
Angew.Chem.Int.Ed.Engl., 53, 2014
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3WEJ
 | | Crystal structure of the human squalene synthase F288A mutant in complex with presqualene pyrophosphate | | 分子名称: | MAGNESIUM ION, Squalene synthase, {(1R,2R,3R)-2-[(3E)-4,8-dimethylnona-3,7-dien-1-yl]-2-methyl-3-[(1E,5E)-2,6,10-trimethylundeca-1,5,9-trien-1-yl]cyclopropyl}methyl trihydrogen diphosphate | | 著者 | Liu, C.I, Jeng, W.Y, Wang, A.H.J. | | 登録日 | 2013-07-07 | | 公開日 | 2014-02-12 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structural insights into the catalytic mechanism of human squalene synthase.
Acta Crystallogr.,Sect.D, 70, 2014
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3WEG
 | | Crystal structure of the human squalene synthase in complex with farnesyl thiopyrophosphate and magnesium ion | | 分子名称: | MAGNESIUM ION, S-[(2E,6E)-3,7,11-TRIMETHYLDODECA-2,6,10-TRIENYL] TRIHYDROGEN THIODIPHOSPHATE, Squalene synthase | | 著者 | Liu, C.I, Jeng, W.Y, Wang, A.H.J. | | 登録日 | 2013-07-07 | | 公開日 | 2014-02-12 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Structural insights into the catalytic mechanism of human squalene synthase.
Acta Crystallogr.,Sect.D, 70, 2014
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2PJF
 | | Solution structure of rhodostomin | | 分子名称: | Rhodostoxin-disintegrin rhodostomin | | 著者 | Chuang, W.J, Chen, Y.C, Chen, C.Y, Chang, Y.T. | | 登録日 | 2007-04-16 | | 公開日 | 2007-05-08 | | 最終更新日 | 2022-03-16 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Effect of D to E mutation of the RGD motif in rhodostomin on its activity, structure, and dynamics: Importance of the interactions between the D residue and integrin
Proteins, 2009
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2PJG
 | | Solution structure of rhodostomin D51E mutant | | 分子名称: | Rhodostoxin-disintegrin rhodostomin | | 著者 | Chuang, W.J, Chen, Y.C, Chen, C.Y, Chou, L.J. | | 登録日 | 2007-04-16 | | 公開日 | 2007-05-08 | | 最終更新日 | 2021-11-10 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Effect of D to E mutation of the RGD motif in rhodostomin on its activity, structure, and dynamics: Importance of the interactions between the D residue and integrin
Proteins, 2009
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4EJT
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3NPR
 | | Crystal structure of the C(30) carotenoid dehydrosqualene synthase from S. aureus complexed with Presqualene diphosphate (PSPP) | | 分子名称: | Dehydrosqualene synthase, MAGNESIUM ION, {(1R,2R,3R)-2-[(3E)-4,8-dimethylnona-3,7-dien-1-yl]-2-methyl-3-[(1E,5E)-2,6,10-trimethylundeca-1,5,9-trien-1-yl]cyclopropyl}methyl trihydrogen diphosphate | | 著者 | Lin, F.-Y, Liu, C.-I, Liu, Y.-L, Wang, K, Zhang, Y, Oldfield, E. | | 登録日 | 2010-06-28 | | 公開日 | 2010-12-22 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Mechanism of action and inhibition of dehydrosqualene synthase.
Proc.Natl.Acad.Sci.USA, 107, 2010
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