3NPR

Crystal structure of the C(30) carotenoid dehydrosqualene synthase from S. aureus complexed with Presqualene diphosphate (PSPP)

Summary for 3NPR

Entry DOI	10.2210/pdb3npr/pdb
Related	2ZCO 2ZCP
Descriptor	Dehydrosqualene synthase, {(1R,2R,3R)-2-[(3E)-4,8-dimethylnona-3,7-dien-1-yl]-2-methyl-3-[(1E,5E)-2,6,10-trimethylundeca-1,5,9-trien-1-yl]cyclopropyl}methyl trihydrogen diphosphate, MAGNESIUM ION, ... (4 entities in total)
Functional Keywords	dehydrosqualene synthase, crtm, presqualene diphosphate, pspp, virulence factor, carotenoid, transferase
Biological source	Staphylococcus aureus
Total number of polymer chains	1
Total formula weight	35422.78
Authors	Lin, F.-Y.,Liu, C.-I.,Liu, Y.-L.,Wang, K.,Zhang, Y.,Oldfield, E. (deposition date: 2010-06-28, release date: 2010-12-22, Last modification date: 2023-09-06)
Primary citation	Lin, F.Y.,Liu, C.I.,Liu, Y.L.,Zhang, Y.,Wang, K.,Jeng, W.Y.,Ko, T.P.,Cao, R.,Wang, A.H.,Oldfield, E. Mechanism of action and inhibition of dehydrosqualene synthase. Proc.Natl.Acad.Sci.USA, 107:21337-21342, 2010 Cited by PubMed: 21098670 DOI: 10.1073/pnas.1010907107 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation