7DRX
| Cryo-EM structure of Dnf1 from Saccharomyces cerevisiae in 90PS with beryllium fluoride (E2P state) | Descriptor: | (4S,7R)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSAN-1-AMINIUM 4-OXIDE, Alkylphosphocholine resistance protein LEM3, BERYLLIUM TRIFLUORIDE ION, ... | Authors: | Xu, J, He, Y, Wu, X, Li, L. | Deposit date: | 2020-12-30 | Release date: | 2022-03-23 | Last modified: | 2022-03-30 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Conformational changes of a phosphatidylcholine flippase in lipid membranes. Cell Rep, 38, 2022
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7DSI
| Cryo-EM structure of Dnf1 from Saccharomyces cerevisiae in yeast lipids with AMPPCP ( resting state ) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alkylphosphocholine resistance protein LEM3, ... | Authors: | Xu, J, He, Y, Wu, X, Li, L. | Deposit date: | 2020-12-31 | Release date: | 2022-03-23 | Last modified: | 2022-04-20 | Method: | ELECTRON MICROSCOPY (3.21 Å) | Cite: | Conformational changes of a phosphatidylcholine flippase in lipid membranes. Cell Rep, 38, 2022
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7DSH
| Cryo-EM structure of Dnf1 from Saccharomyces cerevisiae in 90PS with AMPPCP (E1-ATP state) | Descriptor: | Alkylphosphocholine resistance protein LEM3, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... | Authors: | Xu, J, He, Y, Wu, X, Li, L. | Deposit date: | 2020-12-31 | Release date: | 2022-03-23 | Last modified: | 2022-03-30 | Method: | ELECTRON MICROSCOPY (3.67 Å) | Cite: | Conformational changes of a phosphatidylcholine flippase in lipid membranes. Cell Rep, 38, 2022
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7WHV
| Cryo-EM structure of Dnf1 from Saccharomyces cerevisiae in detergent with beryllium fluoride (E2P state) | Descriptor: | (4S,7R)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSAN-1-AMINIUM 4-OXIDE, Alkylphosphocholine resistance protein LEM3, BERYLLIUM TRIFLUORIDE ION, ... | Authors: | Xu, J, He, Y, Wu, X, Li, L. | Deposit date: | 2021-12-31 | Release date: | 2022-03-23 | Last modified: | 2022-03-30 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Conformational changes of a phosphatidylcholine flippase in lipid membranes. Cell Rep, 38, 2022
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7WHW
| Cryo-EM structure of Dnf1 from Saccharomyces cerevisiae in detergent with AMPPCP (E1-ATP state) | Descriptor: | Alkylphosphocholine resistance protein LEM3, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... | Authors: | Xu, J, He, Y, Wu, X, Li, L. | Deposit date: | 2021-12-31 | Release date: | 2022-03-23 | Last modified: | 2022-03-30 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Conformational changes of a phosphatidylcholine flippase in lipid membranes. Cell Rep, 38, 2022
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6JLI
| Crystal structure of CTLD7 domain of human PLA2R | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Secretory phospholipase A2 receptor | Authors: | Yu, B, Hu, Z, Kong, D, Cheng, C, He, Y. | Deposit date: | 2019-03-06 | Release date: | 2019-07-17 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.778 Å) | Cite: | Crystal structure of the CTLD7 domain of human M-type phospholipase A2 receptor. J.Struct.Biol., 207, 2019
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5K0M
| Targeting the PRC2 complex through a novel protein-protein interaction inhibitor of EED | Descriptor: | (3R,4S)-1-[(1S)-7-fluoro-2,3-dihydro-1H-inden-1-yl]-N,N-dimethyl-4-{4-[4-(methylsulfonyl)piperazin-1-yl]phenyl}pyrrolidin-3-amine, Polycomb protein EED | Authors: | Jakob, C.G, Bigelow, L.J, Zhu, H, Sun, C. | Deposit date: | 2016-05-17 | Release date: | 2017-01-25 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.83 Å) | Cite: | The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complex. Nat. Chem. Biol., 13, 2017
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7PRM
| CRYSTAL STRUCTURE OF HUMAN MONOGLYCERIDE LIPASE WITH COMPOUND 13 | Descriptor: | (4~{R})-1-[4-(4-fluorophenyl)phenyl]-4-[4-(furan-2-ylcarbonyl)piperazin-1-yl]pyrrolidin-2-one, 1,2-ETHANEDIOL, Monoglyceride lipase | Authors: | Grether, U, Gobbi, L, Kuhn, B, Collin, L, Leibrock, L, Heer, D, Wittwer, M, Benz, J. | Deposit date: | 2021-09-22 | Release date: | 2022-02-16 | Last modified: | 2022-02-23 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Development of High Brain-Penetrant and Reversible Monoacylglycerol Lipase PET Tracers for Neuroimaging. J.Med.Chem., 65, 2022
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7YVR
| Crystal Structure of L-Threonine Aldolase from Neptunomonas marina | Descriptor: | GLYCEROL, L-threonine aldolase | Authors: | He, Y.Z, Wang, J, Yan, W.P, Zhang, Y, Feng, Y. | Deposit date: | 2022-08-19 | Release date: | 2023-05-24 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Discovery and Engineering of the L-Threonine Aldolase from Neptunomonas marine for the Efficient Synthesis of beta-Hydroxy-alpha-amino Acids via C-C Formation Acs Catalysis, 2023
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5ZFL
| Crystal structure of beta-lactamase PenP mutant E166Y | Descriptor: | 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Beta-lactamase | Authors: | Pan, X, Zhao, Y. | Deposit date: | 2018-03-06 | Release date: | 2019-03-20 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | The hydrolytic water molecule of Class A beta-lactamase relies on the acyl-enzyme intermediate ES* for proper coordination and catalysis. Sci Rep, 10, 2020
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5ZG6
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5ZFT
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5NMI
| Cytochrome bc1 bound to the inhibitor MJM170 | Descriptor: | (4aS)-2-methyl-3-(4-phenoxyphenyl)-5,6,7,8-tetrahydroquinolin-4(4aH)-one, 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine, ARG-ASN-TRP-VAL-PRO-THR-ALA-GLN-LEU-TRP-GLY-ALA-VAL-GLY-ALA-VAL-GLY-LEU-VAL-SER-ALA-THR, ... | Authors: | Capper, N.J, Antonyuk, S.V, Hasnain, S.S. | Deposit date: | 2017-04-05 | Release date: | 2017-06-14 | Last modified: | 2018-12-19 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | New paradigms for understanding and step changes in treating active and chronic, persistent apicomplexan infections. Sci Rep, 6, 2016
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5HV2
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5HV1
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5HV6
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5HV3
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8E6Y
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4RDD
| Co-crystal structure of SHP2 in complex with a Cefsulodin derivative | Descriptor: | 1-({(2R)-4-carboxy-2-[(R)-carboxy{[(2R)-2-phenyl-2-sulfoacetyl]amino}methyl]-3,6-dihydro-2H-1,3-thiazin-5-yl}methyl)pyridinium, Tyrosine-protein phosphatase non-receptor type 11 | Authors: | Zhang, Z.Y, Yu, Z.H, He, R, Zhang, R.Y. | Deposit date: | 2014-09-18 | Release date: | 2015-07-01 | Last modified: | 2015-12-16 | Method: | X-RAY DIFFRACTION (1.601 Å) | Cite: | Exploring the Existing Drug Space for Novel pTyr Mimetic and SHP2 Inhibitors. ACS Med Chem Lett, 6, 2015
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2MVT
| Solution structure of scoloptoxin SSD609 from Scolopendra mutilans | Descriptor: | Scoloptoxin SSD609 | Authors: | Wu, F, Sun, P, Wang, C, He, Y, Zhang, L, Tian, C. | Deposit date: | 2014-10-14 | Release date: | 2015-09-23 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | A distinct three-helix centipede toxin SSD609 inhibits Iks channels by interacting with the KCNE1 auxiliary subunit. Sci Rep, 5, 2015
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6UAI
| Imidazole-triggered RAS-specific subtilisin SUBT_BACAM complexed with YSAM peptide | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | Authors: | Toth, E.A, Bryan, P.N, Orban, J. | Deposit date: | 2019-09-10 | Release date: | 2020-09-16 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | Engineering subtilisin proteases that specifically degrade active RAS. Commun Biol, 4, 2021
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6UAO
| Imidazole-triggered RAS-specific subtilisin SUBT_BACAM complexed with the peptide EEYSAM | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, Peptide EEYSAM, ... | Authors: | Toth, E.A, Bryan, P.N, Orban, J. | Deposit date: | 2019-09-11 | Release date: | 2020-09-16 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.63 Å) | Cite: | Engineering subtilisin proteases that specifically degrade active RAS. Commun Biol, 4, 2021
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6UBE
| Azide-triggered subtilisin SUBT_BACAM complexed with the peptide LFRAL | Descriptor: | AZIDE ION, GLYCEROL, Peptide LFRAL, ... | Authors: | Toth, E.A, Bryan, P.N, Orban, J, Gallagher, D.T, Custer, G. | Deposit date: | 2019-09-11 | Release date: | 2020-09-16 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Engineering subtilisin proteases that specifically degrade active RAS. Commun Biol, 4, 2021
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6U9L
| Imidazole-triggered RAS-specific subtilisin SUBT_BACAM | Descriptor: | GLYCEROL, POTASSIUM ION, SUBTILISIN BPN', ... | Authors: | Toth, E.A, Bryan, P.N, Orban, J. | Deposit date: | 2019-09-09 | Release date: | 2020-09-16 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Engineering subtilisin proteases that specifically degrade active RAS. Commun Biol, 4, 2021
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8GY9
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