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Crystal Structure of MERS-CoV neutralizing antibody G4 Fab
分子名称:	G4 antibody heavy chain, G4 antibody light chain, GLYCEROL
著者	Wang, N, Wrapp, D, McLellan, J.S.
登録日	2017-05-29
公開日	2017-08-30
最終更新日	2023-10-04
実験手法	X-RAY DIFFRACTION (1.57 Å)
主引用文献	Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen. Proc. Natl. Acad. Sci. U.S.A., 114, 2017

5W9O

MERS S ectodomain trimer in complex with variable domain of neutralizing antibody G4
分子名称:	G4 VH, G4 VL, Spike glycoprotein
著者	Pallesen, J, Ward, A.B.
登録日	2017-06-23
公開日	2017-08-16
最終更新日	2020-01-01
実験手法	ELECTRON MICROSCOPY (4.5 Å)
主引用文献	Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen. Proc. Natl. Acad. Sci. U.S.A., 114, 2017

5W9L

MERS S ectodomain trimer in complex with variable domain of neutralizing antibody G4
分子名称:	G4 VH, G4 VL, Spike glycoprotein
著者	Pallesen, J, Ward, A.B.
登録日	2017-06-23
公開日	2017-08-16
最終更新日	2019-12-11
実験手法	ELECTRON MICROSCOPY (4.8 Å)
主引用文献	Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen. Proc. Natl. Acad. Sci. U.S.A., 114, 2017

5W9H

MERS S ectodomain trimer in complex with variable domain of neutralizing antibody G4
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, G4 VH, ...
著者	Pallesen, J, Ward, A.B.
登録日	2017-06-23
公開日	2017-08-16
最終更新日	2020-07-29
実験手法	ELECTRON MICROSCOPY (4 Å)
主引用文献	Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen. Proc. Natl. Acad. Sci. U.S.A., 114, 2017

3QWO

Crystal structure of a motavizumab epitope-scaffold bound to motavizumab Fab
分子名称:	1,2-ETHANEDIOL, SULFATE ION, motavizumab epitope scaffold, ...
著者	McLellan, J.S, Kwong, P.D.
登録日	2011-02-28
公開日	2011-05-04
最終更新日	2023-09-13
実験手法	X-RAY DIFFRACTION (1.9 Å)
主引用文献	Design and characterization of epitope-scaffold immunogens that present the motavizumab epitope from respiratory syncytial virus. J.Mol.Biol., 409, 2011

6CS1

SARS Spike Glycoprotein, Trypsin-cleaved, Stabilized variant, two S1 CTDs in an upwards conformation
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein,Fibritin, ...
著者	Kirchdoerfer, R.N, Wang, N, Pallesen, J, Turner, H.L, Cottrell, C.A, McLellan, J.S, Ward, A.B.
登録日	2018-03-19
公開日	2018-04-11
最終更新日	2020-07-29
実験手法	ELECTRON MICROSCOPY (4.6 Å)
主引用文献	Stabilized coronavirus spikes are resistant to conformational changes induced by receptor recognition or proteolysis. Sci Rep, 8, 2018

7S3N

SARS-CoV-2 S stem helix peptide bound to Fab22
分子名称:	Fab22 Heavy Chain, Fab22 Light Chain, Spike glycoprotein
著者	Goldsmith, J.A, McLellan, J.S.
登録日	2021-09-07
公開日	2021-10-27
最終更新日	2023-10-18
実験手法	X-RAY DIFFRACTION (1.9 Å)
主引用文献	Stabilized coronavirus spike stem elicits a broadly protective antibody. Cell Rep, 37, 2021

7S3M

MERS-CoV S stem helix peptide bound to Fab22
分子名称:	Fab22 Heavy Chain, Fab22 Light Chain, Spike glycoprotein
著者	Goldsmith, J.A, McLellan, J.S.
登録日	2021-09-07
公開日	2021-10-27
最終更新日	2023-10-18
実験手法	X-RAY DIFFRACTION (2.4 Å)
主引用文献	Stabilized coronavirus spike stem elicits a broadly protective antibody. Cell Rep, 37, 2021

7SG4

Structure of SARS-CoV S protein in complex with Receptor Binding Domain antibody DH1047
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, DH1047 Heavy chain, DH1047 light chain, ...
著者	Gobeil, S, Acharya, P.
登録日	2021-10-04
公開日	2021-11-10
最終更新日	2022-02-09
実験手法	ELECTRON MICROSCOPY (3.43 Å)
主引用文献	A broadly cross-reactive antibody neutralizes and protects against sarbecovirus challenge in mice. Sci Transl Med, 14, 2022

6CS0

SARS Spike Glycoprotein, Trypsin-cleaved, Stabilized variant, one S1 CTD in an upwards conformation
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein,Fibritin, ...
著者	Kirchdoerfer, R.N, Wang, N, Pallesen, J, Turner, H.L, Cottrell, C.A, McLellan, J.S, Ward, A.B.
登録日	2018-03-19
公開日	2018-04-11
最終更新日	2020-07-29
実験手法	ELECTRON MICROSCOPY (3.8 Å)
主引用文献	Stabilized coronavirus spikes are resistant to conformational changes induced by receptor recognition or proteolysis. Sci Rep, 8, 2018

7TB4

Cryo-EM structure of the spike of SARS-CoV-2 Omicron variant of concern
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Surface glycoprotein
著者	Zhou, T, Tsybovsky, T, Kwong, P.D.
登録日	2021-12-21
公開日	2022-01-12
最終更新日	2022-01-19
実験手法	ELECTRON MICROSCOPY (3.29 Å)
主引用文献	Antibodies with potent and broad neutralizing activity against antigenically diverse and highly transmissible SARS-CoV-2 variants. Biorxiv, 2021

6CS2

SARS Spike Glycoprotein - human ACE2 complex, Stabilized variant, all ACE2-bound particles
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, ...
著者	Kirchdoerfer, R.N, Wang, N, Pallesen, J, Turner, H.L, Cottrell, C.A, McLellan, J.S, Ward, A.B.
登録日	2018-03-19
公開日	2018-04-11
最終更新日	2020-07-29
実験手法	ELECTRON MICROSCOPY (4.4 Å)
主引用文献	Stabilized coronavirus spikes are resistant to conformational changes induced by receptor recognition or proteolysis. Sci Rep, 8, 2018

6CRX

SARS Spike Glycoprotein, Stabilized variant, two S1 CTDs in the upwards conformation
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein,Fibritin, ...
著者	Kirchdoerfer, R.N, Wang, N, Pallesen, J, Turner, H.L, Cottrell, C.A, McLellan, J.S, Ward, A.B.
登録日	2018-03-19
公開日	2018-04-11
最終更新日	2020-07-29
実験手法	ELECTRON MICROSCOPY (3.9 Å)
主引用文献	Stabilized coronavirus spikes are resistant to conformational changes induced by receptor recognition or proteolysis. Sci Rep, 8, 2018

7TB8

Cryo-EM structure of SARS-CoV-2 spike in complex with antibodies B1-182.1 and A19-61.1
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者	Zhou, T, Tsybovsky, T, Kwong, P.D.
登録日	2021-12-21
公開日	2022-03-30
最終更新日	2022-10-19
実験手法	ELECTRON MICROSCOPY (2.83 Å)
主引用文献	Structural basis for potent antibody neutralization of SARS-CoV-2 variants including B.1.1.529. Science, 376, 2022

7TCA

Cryo-EM structure of SARS-CoV-2 Omicron spike in complex with antibody A19-46.1
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of antibody A19-46.1, ...
著者	Zhou, T, Kwong, P.D.
登録日	2021-12-23
公開日	2022-03-30
最終更新日	2022-10-19
実験手法	ELECTRON MICROSCOPY (3.85 Å)
主引用文献	Structural basis for potent antibody neutralization of SARS-CoV-2 variants including B.1.1.529. Science, 376, 2022

7TBF

Locally refined region of SARS-CoV-2 spike in complex with antibodies B1-182.1 and A19-61.1
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of SARS-CoV-2 antibody A19-61.1, Heavy chain of SARS-CoV-2 antibody B1-182.1, ...
著者	Zhou, T, Tsybovsky, T, Kwong, P.D.
登録日	2021-12-21
公開日	2022-03-30
最終更新日	2022-10-19
実験手法	ELECTRON MICROSCOPY (3.1 Å)
主引用文献	Structural basis for potent antibody neutralization of SARS-CoV-2 variants including B.1.1.529. Science, 376, 2022

7TCC

Cryo-EM structure of SARS-CoV-2 Omicron spike in complex with antibodies A19-46.1 and B1-182.1
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of antibody A19-46.1, ...
著者	Zhou, T, Kwong, P.D.
登録日	2021-12-23
公開日	2022-03-30
最終更新日	2022-10-19
実験手法	ELECTRON MICROSCOPY (3.86 Å)
主引用文献	Structural basis for potent antibody neutralization of SARS-CoV-2 variants including B.1.1.529. Science, 376, 2022

6CRW

SARS Spike Glycoprotein, Stabilized variant, single upwards S1 CTD conformation
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein,Fibritin, ...
著者	Kirchdoerfer, R.N, Wang, N, Pallesen, J, Turner, H.L, Cottrell, C.A, McLellan, J.S, Ward, A.B.
登録日	2018-03-19
公開日	2018-04-11
最終更新日	2020-07-29
実験手法	ELECTRON MICROSCOPY (3.9 Å)
主引用文献	Stabilized coronavirus spikes are resistant to conformational changes induced by receptor recognition or proteolysis. Sci Rep, 8, 2018

7TC9

Locally refined region of SARS-CoV-2 spike in complex with antibody A19-46.1
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of antibody A19-46.1, Light chain of antibody A19-46.1, ...
著者	Zhou, T, Kwong, P.D.
登録日	2021-12-23
公開日	2022-03-30
最終更新日	2022-10-19
実験手法	ELECTRON MICROSCOPY (5.08 Å)
主引用文献	Structural basis for potent antibody neutralization of SARS-CoV-2 variants including B.1.1.529. Science, 376, 2022

7NS6

SARS-CoV-2 Spike (dimers) in complex with six Fu2 nanobodies
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, Fu2 nanobody, Spike glycoprotein,Fibritin, ...
著者	Das, H, Hallberg, B.M.
登録日	2021-03-05
公開日	2022-02-02
実験手法	ELECTRON MICROSCOPY (3.18 Å)
主引用文献	A bispecific monomeric nanobody induces spike trimer dimers and neutralizes SARS-CoV-2 in vivo. Nat Commun, 13, 2022

4ZPT

Structure of MERS-Coronavirus Spike Receptor-binding Domain (England1 Strain) in Complex with Vaccine-Elicited Murine Neutralizing Antibody D12 (Crystal Form 1)
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, D12 Fab Heavy chain, D12 Fab Light chain, ...
著者	Joyce, M.G, Mascola, J.R, Graham, B.S, Kwong, P.D.
登録日	2015-05-08
公開日	2015-10-21
最終更新日	2020-07-29
実験手法	X-RAY DIFFRACTION (2.591 Å)
主引用文献	Evaluation of candidate vaccine approaches for MERS-CoV Nat Commun, 6, 2015

4OLY

Crystal structure of antibody VRC07-G54R in complex with clade A/E 93TH057 HIV-1 gp120 core
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, Antigen binding fragment of heavy chain: Antibody VRC01, Antigen binding fragment of light chain: Antibody VRC01, ...
著者	Kwon, Y.D, Kwong, P.D.
登録日	2014-01-25
公開日	2014-09-03
最終更新日	2023-09-20
実験手法	X-RAY DIFFRACTION (2.351 Å)
主引用文献	Enhanced Potency of a Broadly Neutralizing HIV-1 Antibody In Vitro Improves Protection against Lentiviral Infection In Vivo. J.Virol., 88, 2014

4OM0

Crystal structure of antibody VRC07-G54Y in complex with clade A/E 93TH057 HIV-1 gp120 core
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, Antigen binding fragment of heavy chain: Antibody VRC01, Antigen binding fragment of light chain: Antibody VRC01, ...
著者	Kwon, Y.D, Kwong, P.D.
登録日	2014-01-25
公開日	2014-09-03
最終更新日	2023-09-20
実験手法	X-RAY DIFFRACTION (2.289 Å)
主引用文献	Enhanced Potency of a Broadly Neutralizing HIV-1 Antibody In Vitro Improves Protection against Lentiviral Infection In Vivo. J.Virol., 88, 2014

4OLW

Crystal structure of antibody VRC07-G54H in complex with clade A/E 93TH057 HIV-1 gp120 core
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, Antigen binding fragment of heavy chain: Antibody VRC01, Antigen binding fragment of light chain: Antibody VRC01, ...
著者	Kwon, Y.D, Kwong, P.D.
登録日	2014-01-25
公開日	2014-09-03
最終更新日	2023-09-20
実験手法	X-RAY DIFFRACTION (2.709 Å)
主引用文献	Enhanced Potency of a Broadly Neutralizing HIV-1 Antibody In Vitro Improves Protection against Lentiviral Infection In Vivo. J.Virol., 88, 2014

4N9G

Crystal Structure of a Computationally Designed RSV-Presenting Epitope Scaffold And Its Elicited Antibody 17HD9
分子名称:	Antibody 17HD9, Heavy Chain, Light Chain, ...
著者	Carrico, C.T.D, Strong, R.K.
登録日	2013-10-21
公開日	2014-02-12
最終更新日	2023-09-20
実験手法	X-RAY DIFFRACTION (2.5 Å)
主引用文献	Proof of principle for epitope-focused vaccine design. Nature, 507, 2014

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