7NS6

SARS-CoV-2 Spike (dimers) in complex with six Fu2 nanobodies

Summary for 7NS6

• Entry DOI: 10.2210/pdb7ns6/pdb
• EMDB information: 12561
• Descriptor: Fu2 nanobody, Spike glycoprotein,Fibritin, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• Functional Keywords: nanobody, spike, complex, dimer, viral protein
• Biological source: Vicugna pacos (alpaca); More
• Total number of polymer chains: 12
• Total formula weight: 961368.94

Authors

Das, H.,Hallberg, B.M. (deposition date: 2021-03-05, release date: 2022-02-02)

• Primary citation: Hanke, L.,Das, H.,Sheward, D.J.,Perez Vidakovics, L.,Urgard, E.,Moliner-Morro, A.,Kim, C.,Karl, V.,Pankow, A.,Smith, N.L.,Porebski, B.,Fernandez-Capetillo, O.,Sezgin, E.,Pedersen, G.K.,Coquet, J.M.,Hallberg, B.M.,Murrell, B.,McInerney, G.M.; A bispecific monomeric nanobody induces spike trimer dimers and neutralizes SARS-CoV-2 in vivo.; Nat Commun, 13:155-155, 2022; PubMed: 35013189; DOI: 10.1038/s41467-021-27610-z

Experimental method

ELECTRON MICROSCOPY (3.18 Å)