7NS6
SARS-CoV-2 Spike (dimers) in complex with six Fu2 nanobodies
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| I | 0016020 | cellular_component | membrane |
| I | 0019031 | cellular_component | viral envelope |
| I | 0019064 | biological_process | fusion of virus membrane with host plasma membrane |
| I | 0039654 | biological_process | fusion of virus membrane with host endosome membrane |
| I | 0046813 | biological_process | receptor-mediated virion attachment to host cell |
| I | 0055036 | cellular_component | virion membrane |
| I | 0075509 | biological_process | endocytosis involved in viral entry into host cell |
| J | 0016020 | cellular_component | membrane |
| J | 0019031 | cellular_component | viral envelope |
| J | 0019064 | biological_process | fusion of virus membrane with host plasma membrane |
| J | 0039654 | biological_process | fusion of virus membrane with host endosome membrane |
| J | 0046813 | biological_process | receptor-mediated virion attachment to host cell |
| J | 0055036 | cellular_component | virion membrane |
| J | 0075509 | biological_process | endocytosis involved in viral entry into host cell |
| K | 0016020 | cellular_component | membrane |
| K | 0019031 | cellular_component | viral envelope |
| K | 0019064 | biological_process | fusion of virus membrane with host plasma membrane |
| K | 0039654 | biological_process | fusion of virus membrane with host endosome membrane |
| K | 0046813 | biological_process | receptor-mediated virion attachment to host cell |
| K | 0055036 | cellular_component | virion membrane |
| K | 0075509 | biological_process | endocytosis involved in viral entry into host cell |
| L | 0016020 | cellular_component | membrane |
| L | 0019031 | cellular_component | viral envelope |
| L | 0019064 | biological_process | fusion of virus membrane with host plasma membrane |
| L | 0039654 | biological_process | fusion of virus membrane with host endosome membrane |
| L | 0046813 | biological_process | receptor-mediated virion attachment to host cell |
| L | 0055036 | cellular_component | virion membrane |
| L | 0075509 | biological_process | endocytosis involved in viral entry into host cell |
| M | 0016020 | cellular_component | membrane |
| M | 0019031 | cellular_component | viral envelope |
| M | 0019064 | biological_process | fusion of virus membrane with host plasma membrane |
| M | 0039654 | biological_process | fusion of virus membrane with host endosome membrane |
| M | 0046813 | biological_process | receptor-mediated virion attachment to host cell |
| M | 0055036 | cellular_component | virion membrane |
| M | 0075509 | biological_process | endocytosis involved in viral entry into host cell |
| N | 0016020 | cellular_component | membrane |
| N | 0019031 | cellular_component | viral envelope |
| N | 0019064 | biological_process | fusion of virus membrane with host plasma membrane |
| N | 0039654 | biological_process | fusion of virus membrane with host endosome membrane |
| N | 0046813 | biological_process | receptor-mediated virion attachment to host cell |
| N | 0055036 | cellular_component | virion membrane |
| N | 0075509 | biological_process | endocytosis involved in viral entry into host cell |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | SITE: Cleavage; by host furin => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32142651, ECO:0000269|PubMed:32362314, ECO:0000269|PubMed:32703818, ECO:0000269|PubMed:34159616 |
| Chain | Residue | Details |
| I | SER685 | |
| K | SER685 | |
| M | SER685 | |
| J | SER685 | |
| L | SER685 | |
| N | SER685 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | SITE: Cleavage; by host TMPRSS2 or CTSL => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32703818, ECO:0000269|PubMed:34159616 |
| Chain | Residue | Details |
| I | ARG815 | |
| K | ARG815 | |
| M | ARG815 | |
| J | ARG815 | |
| L | ARG815 | |
| N | ARG815 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 18 |
| Details | CARBOHYD: N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942 |
| Chain | Residue | Details |
| I | ASN17 | |
| J | ASN17 | |
| J | ASN1158 | |
| J | ASN1173 | |
| L | ASN17 | |
| L | ASN1158 | |
| L | ASN1173 | |
| N | ASN17 | |
| N | ASN1158 | |
| N | ASN1173 | |
| I | ASN1158 | |
| I | ASN1173 | |
| K | ASN17 | |
| K | ASN1158 | |
| K | ASN1173 | |
| M | ASN17 | |
| M | ASN1158 | |
| M | ASN1173 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 30 |
| Details | CARBOHYD: N-linked (GlcNAc...) (hybrid) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942 |
| Chain | Residue | Details |
| I | ASN61 | |
| K | ASN1074 | |
| M | ASN61 | |
| M | ASN122 | |
| M | ASN717 | |
| M | ASN801 | |
| M | ASN1074 | |
| J | ASN61 | |
| J | ASN122 | |
| J | ASN717 | |
| J | ASN801 | |
| I | ASN122 | |
| J | ASN1074 | |
| L | ASN61 | |
| L | ASN122 | |
| L | ASN717 | |
| L | ASN801 | |
| L | ASN1074 | |
| N | ASN61 | |
| N | ASN122 | |
| N | ASN717 | |
| N | ASN801 | |
| I | ASN717 | |
| N | ASN1074 | |
| I | ASN801 | |
| I | ASN1074 | |
| K | ASN61 | |
| K | ASN122 | |
| K | ASN717 | |
| K | ASN801 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 18 |
| Details | CARBOHYD: N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942 |
| Chain | Residue | Details |
| I | ASN74 | |
| J | ASN74 | |
| J | ASN149 | |
| J | ASN1194 | |
| L | ASN74 | |
| L | ASN149 | |
| L | ASN1194 | |
| N | ASN74 | |
| N | ASN149 | |
| N | ASN1194 | |
| I | ASN149 | |
| I | ASN1194 | |
| K | ASN74 | |
| K | ASN149 | |
| K | ASN1194 | |
| M | ASN74 | |
| M | ASN149 | |
| M | ASN1194 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 42 |
| Details | CARBOHYD: N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942 |
| Chain | Residue | Details |
| I | ASN165 | |
| K | ASN331 | |
| K | ASN343 | |
| K | ASN616 | |
| K | ASN657 | |
| K | ASN1098 | |
| M | ASN165 | |
| M | ASN282 | |
| M | ASN331 | |
| M | ASN343 | |
| M | ASN616 | |
| I | ASN282 | |
| M | ASN657 | |
| M | ASN1098 | |
| J | ASN165 | |
| J | ASN282 | |
| J | ASN331 | |
| J | ASN343 | |
| J | ASN616 | |
| J | ASN657 | |
| J | ASN1098 | |
| L | ASN165 | |
| I | ASN331 | |
| L | ASN282 | |
| L | ASN331 | |
| L | ASN343 | |
| L | ASN616 | |
| L | ASN657 | |
| L | ASN1098 | |
| N | ASN165 | |
| N | ASN282 | |
| N | ASN331 | |
| N | ASN343 | |
| I | ASN343 | |
| N | ASN616 | |
| N | ASN657 | |
| N | ASN1098 | |
| I | ASN616 | |
| I | ASN657 | |
| I | ASN1098 | |
| K | ASN165 | |
| K | ASN282 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 12 |
| Details | CARBOHYD: N-linked (GlcNAc...) (high mannose) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942 |
| Chain | Residue | Details |
| I | ASN234 | |
| L | ASN709 | |
| N | ASN234 | |
| N | ASN709 | |
| I | ASN709 | |
| K | ASN234 | |
| K | ASN709 | |
| M | ASN234 | |
| M | ASN709 | |
| J | ASN234 | |
| J | ASN709 | |
| L | ASN234 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 6 |
| Details | CARBOHYD: O-linked (GalNAc) threonine; by host => ECO:0000269|PubMed:32363391 |
| Chain | Residue | Details |
| I | THR323 | |
| K | THR323 | |
| M | THR323 | |
| J | THR323 | |
| L | THR323 | |
| N | THR323 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 6 |
| Details | CARBOHYD: O-linked (HexNAc...) serine; by host => ECO:0000269|PubMed:32363391 |
| Chain | Residue | Details |
| I | SER325 | |
| K | SER325 | |
| M | SER325 | |
| J | SER325 | |
| L | SER325 | |
| N | SER325 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 6 |
| Details | CARBOHYD: N-linked (GlcNAc...) (hybrid) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942 |
| Chain | Residue | Details |
| I | ASN603 | |
| K | ASN603 | |
| M | ASN603 | |
| J | ASN603 | |
| L | ASN603 | |
| N | ASN603 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 12 |
| Details | CARBOHYD: O-linked (GlcNAc...) threonine; by host GALNT1 => ECO:0000269|PubMed:34732583 |
| Chain | Residue | Details |
| I | THR676 | |
| L | THR678 | |
| N | THR676 | |
| N | THR678 | |
| I | THR678 | |
| K | THR676 | |
| K | THR678 | |
| M | THR676 | |
| M | THR678 | |
| J | THR676 | |
| J | THR678 | |
| L | THR676 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 6 |
| Details | CARBOHYD: N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942 |
| Chain | Residue | Details |
| I | ASN1134 | |
| K | ASN1134 | |
| M | ASN1134 | |
| J | ASN1134 | |
| L | ASN1134 | |
| N | ASN1134 |
