7SG4

Structure of SARS-CoV S protein in complex with Receptor Binding Domain antibody DH1047

Summary for 7SG4

• Entry DOI: 10.2210/pdb7sg4/pdb
• Related: 7LD1
• EMDB information: 23279 25105
• Descriptor: Spike glycoprotein, DH1047 Heavy chain, DH1047 light chain, ... (4 entities in total)
• Functional Keywords: sars-cov spike protein trimer, viral protein
• Biological source: Severe acute respiratory syndrome coronavirus (SARS-CoV); More
• Total number of polymer chains: 5
• Total formula weight: 481563.10

Authors

Gobeil, S.,Acharya, P. (deposition date: 2021-10-04, release date: 2021-11-10, Last modification date: 2022-02-09)

• Primary citation: Martinez, D.R.,Schafer, A.,Gobeil, S.,Li, D.,De la Cruz, G.,Parks, R.,Lu, X.,Barr, M.,Stalls, V.,Janowska, K.,Beaudoin, E.,Manne, K.,Mansouri, K.,Edwards, R.J.,Cronin, K.,Yount, B.,Anasti, K.,Montgomery, S.A.,Tang, J.,Golding, H.,Shen, S.,Zhou, T.,Kwong, P.D.,Graham, B.S.,Mascola, J.R.,Montefiori, D.C.,Alam, S.M.,Sempowski, G.,Sempowski, G.D.,Khurana, S.,Wiehe, K.,Saunders, K.O.,Acharya, P.,Haynes, B.F.,Baric, R.S.; A broadly cross-reactive antibody neutralizes and protects against sarbecovirus challenge in mice.; Sci Transl Med, 14:eabj7125-eabj7125, 2022; PubMed: 34726473; DOI: 10.1126/scitranslmed.abj7125

Experimental method

ELECTRON MICROSCOPY (3.43 Å)