7SG4

Structure of SARS-CoV S protein in complex with Receptor Binding Domain antibody DH1047

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C (A, B, C)	Spike glycoprotein	polymer	1270	140644.5	3	UniProt (P59594) Pfam (PF16451) Pfam (PF09408) Pfam (PF01601)	Severe acute respiratory syndrome coronavirus (SARS-CoV)	S glycoprotein,E2,Peplomer protein
2	D (H)	DH1047 Heavy chain	polymer	232	24834.7	1		Homo sapiens (human)
3	E (L)	DH1047 light chain	polymer	220	24398.0	1		Homo sapiens (human)
4	AA, BA, CA, DA, EA... (B, A, C)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	47	Chemie (NAG)

Sequence modifications

A, B, C: 1 - 1190 (UniProt: P59594)

PDB	External Database	Details
Pro 968	Lys 968	engineered mutation
Pro 969	Val 969	engineered mutation
Gly 1191	-	expression tag
Ser 1192	-	expression tag
Gly 1193	-	expression tag
Tyr 1194	-	expression tag
Ile 1195	-	expression tag
Pro 1196	-	expression tag
Glu 1197	-	expression tag
Ala 1198	-	expression tag
Pro 1199	-	expression tag
Arg 1200	-	expression tag
Asp 1201	-	expression tag
Gly 1202	-	expression tag
Gln 1203	-	expression tag
Ala 1204	-	expression tag
Tyr 1205	-	expression tag
Val 1206	-	expression tag
Arg 1207	-	expression tag
Lys 1208	-	expression tag
Asp 1209	-	expression tag
Gly 1210	-	expression tag
Glu 1211	-	expression tag
Trp 1212	-	expression tag
Val 1213	-	expression tag
Leu 1214	-	expression tag
Leu 1215	-	expression tag
Ser 1216	-	expression tag
Thr 1217	-	expression tag
Phe 1218	-	expression tag
Leu 1219	-	expression tag
Gly 1220	-	expression tag
Arg 1221	-	expression tag
Ser 1222	-	expression tag
Leu 1223	-	expression tag
Glu 1224	-	expression tag
Val 1225	-	expression tag
Leu 1226	-	expression tag
Phe 1227	-	expression tag
Gln 1228	-	expression tag
Gly 1229	-	expression tag
Pro 1230	-	expression tag
Gly 1231	-	expression tag
His 1232	-	expression tag
His 1233	-	expression tag
His 1234	-	expression tag
His 1235	-	expression tag
His 1236	-	expression tag
His 1237	-	expression tag
His 1238	-	expression tag
His 1239	-	expression tag
Ser 1240	-	expression tag
Ala 1241	-	expression tag
Trp 1242	-	expression tag
Ser 1243	-	expression tag
His 1244	-	expression tag
Pro 1245	-	expression tag
Gln 1246	-	expression tag
Phe 1247	-	expression tag
Glu 1248	-	expression tag
Lys 1249	-	expression tag
Gly 1250	-	expression tag
Gly 1251	-	expression tag
Gly 1252	-	expression tag
Ser 1253	-	expression tag
Gly 1254	-	expression tag
Gly 1255	-	expression tag
Gly 1256	-	expression tag
Gly 1257	-	expression tag
Ser 1258	-	expression tag
Gly 1259	-	expression tag
Gly 1260	-	expression tag
Ser 1261	-	expression tag
Ala 1262	-	expression tag
Trp 1263	-	expression tag
Ser 1264	-	expression tag
His 1265	-	expression tag
Pro 1266	-	expression tag
Gln 1267	-	expression tag
Phe 1268	-	expression tag
Glu 1269	-	expression tag
Lys 1270	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	471166.3
Non-Polymers*	Number of molecules	47
	Total formula weight	10396.8
All*	Total formula weight	481563.1

*Water molecules are not included.