4ZPT

Structure of MERS-Coronavirus Spike Receptor-binding Domain (England1 Strain) in Complex with Vaccine-Elicited Murine Neutralizing Antibody D12 (Crystal Form 1)

Summary for 4ZPT

Entry DOI	10.2210/pdb4zpt/pdb
Related	4KR0 4ZPV 4ZPW
Descriptor	D12 Fab Heavy chain, D12 Fab Light chain, Spike glycoprotein, ... (5 entities in total)
Functional Keywords	vaccine, immunogen, viral protein-immune system complex, viral protein/immune system
Biological source	Human coronavirus EMC (isolate United Kingdom/H123990006/2012) (HCoV-EMC) More
Cellular location	Spike protein S2: Virion membrane ; Single-pass type I membrane protein . Spike protein S1: Virion membrane ; Peripheral membrane protein : K9N5Q8
Total number of polymer chains	6
Total formula weight	140092.24
Authors	Joyce, M.G.,Mascola, J.R.,Graham, B.S.,Kwong, P.D. (deposition date: 2015-05-08, release date: 2015-10-21, Last modification date: 2020-07-29)
Primary citation	Joyce, M.G. Evaluation of candidate vaccine approaches for MERS-CoV Nat Commun, 6:7712-, 2015 Cited by PubMed: 26218507 DOI: 10.1038/ncomms8712 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.591 Å)

Structure validation