4DW1
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6AWQ
| Anomalous chloride signal reveals the position of sertraline complexed with the serotonin transporter at the central site | 分子名称: | (1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 8B6 antibody FAB heavy chain, ... | 著者 | Coleman, J.A, Gouaux, E. | 登録日 | 2017-09-06 | 公開日 | 2017-10-25 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (4.046 Å) | 主引用文献 | Structural basis for recognition of diverse antidepressants by the human serotonin transporter. Nat. Struct. Mol. Biol., 25, 2018
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6AVE
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6AWN
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4FXZ
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4FY0
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4FZ0
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4FZ1
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6AWP
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6AWO
| X-ray structure of the ts3 human serotonin transporter complexed with sertraline at the central site | 分子名称: | (1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 8B6 antibody FAB heavy chain, ... | 著者 | Coleman, J.A, Gouaux, E. | 登録日 | 2017-09-06 | 公開日 | 2017-10-25 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (3.534 Å) | 主引用文献 | Structural basis for recognition of diverse antidepressants by the human serotonin transporter. Nat. Struct. Mol. Biol., 25, 2018
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7LGW
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7LH3
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7LGU
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7LH2
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2Q6H
| Crystal Structure Analysis of LeuT complexed with L-leucine, sodium, and clomipramine | 分子名称: | 3-(3-CHLORO-5H-DIBENZO[B,F]AZEPIN-5-YL)-N,N-DIMETHYLPROPAN-1-AMINE, LEUCINE, SODIUM ION, ... | 著者 | Singh, S.K, Yamashita, A, Gouaux, E. | 登録日 | 2007-06-05 | 公開日 | 2007-08-21 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Antidepressant binding site in a bacterial homologue of neurotransmitter transporters. Nature, 448, 2007
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2QTS
| Structure of an acid-sensing ion channel 1 at 1.9 A resolution and low pH | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Acid-sensing ion channel, CHLORIDE ION, ... | 著者 | Jasti, J, Furukawa, H, Gonzales, E.B, Gouaux, E. | 登録日 | 2007-08-02 | 公開日 | 2007-09-25 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structure of acid-sensing ion channel 1 at 1.9A resolution and low pH Nature, 449, 2007
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4XP4
| X-ray structure of Drosophila dopamine transporter in complex with cocaine | 分子名称: | 1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE, ANTIBODY FRAGMENT HEAVY CHAIN-PROTEIN, 9D5-HEAVY CHAIN, ... | 著者 | Aravind, P, Wang, K, Gouaux, E. | 登録日 | 2015-01-16 | 公開日 | 2015-05-06 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Neurotransmitter and psychostimulant recognition by the dopamine transporter. Nature, 521, 2015
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4XNU
| X-ray structure of Drosophila dopamine transporter in complex with nisoxetine | 分子名称: | CHLORIDE ION, CHOLESTEROL, Integral membrane protein-dopamine transporter, ... | 著者 | Aravind, P, Wang, K, Gouaux, E. | 登録日 | 2015-01-16 | 公開日 | 2015-05-13 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.98 Å) | 主引用文献 | X-ray structures of Drosophila dopamine transporter in complex with nisoxetine and reboxetine. Nat.Struct.Mol.Biol., 22, 2015
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4XPF
| X-ray structure of Drosophila dopamine transporter with subsiteB mutations (D121G/S426M) bound to RTI-55 | 分子名称: | 1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE, ANTIBODY FRAGMENT HEAVY CHAIN-PROTEIN, 9D5-HEAVY CHAIN, ... | 著者 | Penmatsa, A, Wang, K.H, Gouaux, E. | 登録日 | 2015-01-16 | 公開日 | 2015-05-06 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (3.273 Å) | 主引用文献 | Neurotransmitter and psychostimulant recognition by the dopamine transporter. Nature, 521, 2015
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4XPG
| X-ray structure of Drosophila dopamine transporter with subsiteB mutations (D121G/S426M) bound to beta-CFT or Win35428 | 分子名称: | CHLORIDE ION, CHOLESTEROL, Dopamine transporter, ... | 著者 | Penmatsa, A, Wang, K.H, Gouaux, E. | 登録日 | 2015-01-16 | 公開日 | 2015-05-06 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (3.21 Å) | 主引用文献 | Neurotransmitter and psychostimulant recognition by the dopamine transporter. Nature, 521, 2015
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4XPB
| X-ray structure of Drosophila dopamine transporter with subsiteB mutations (D121G/S426M) bound to cocaine | 分子名称: | Antibody fragment heavy chain-protein, 9D5-heavy chain, Antibody fragment light chain-protein, ... | 著者 | Aravind, P, Wang, K, Gouaux, E. | 登録日 | 2015-01-16 | 公開日 | 2015-05-13 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (3.05 Å) | 主引用文献 | Neurotransmitter and psychostimulant recognition by the dopamine transporter. Nature, 521, 2015
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4XPT
| X-ray structure of Drosophila dopamine transporter with subsiteB mutations D121G/S426M and EL2 deletion of 162-201 in complex with substrate analogue 3,4 dichlorophen ethylamine | 分子名称: | 2-(3,4-dichlorophenyl)ethanamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... | 著者 | Aravind, P, Wang, K, Gouaux, E. | 登録日 | 2015-01-17 | 公開日 | 2015-05-06 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (3.36 Å) | 主引用文献 | Neurotransmitter and psychostimulant recognition by the dopamine transporter. Nature, 521, 2015
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4XNX
| X-ray structure of Drosophila dopamine transporter in complex with reboxetine | 分子名称: | (2R)-2-[(R)-(2-ethoxyphenoxy)(phenyl)methyl]morpholine, Antibody fragment heavy chain, CHLORIDE ION, ... | 著者 | Aravind, P, Wang, K, Gouaux, E. | 登録日 | 2015-01-16 | 公開日 | 2015-05-13 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | X-ray structures of Drosophila dopamine transporter in complex with nisoxetine and reboxetine. Nat.Struct.Mol.Biol., 22, 2015
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4XP6
| X-ray structure of Drosophila dopamine transporter bound to psychostimulant methamphetamine | 分子名称: | (2S)-N-methyl-1-phenylpropan-2-amine, 2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody fragment heavy chain-protein, ... | 著者 | Aravind, P, Wang, K, Gouaux, E. | 登録日 | 2015-01-16 | 公開日 | 2015-05-13 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Neurotransmitter and psychostimulant recognition by the dopamine transporter. Nature, 521, 2015
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4XPH
| X-ray structure of Drosophila dopamine transporter with subsiteB mutations (D121G/S426M) bound to 3,4dichlorophenethylamine | 分子名称: | 1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE, 2-(3,4-dichlorophenyl)ethanamine, Antibody fragment heavy chain, ... | 著者 | Penmatsa, A, Wang, K, Gouaux, E. | 登録日 | 2015-01-17 | 公開日 | 2015-05-06 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Neurotransmitter and psychostimulant recognition by the dopamine transporter. Nature, 521, 2015
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