2M0M
 
 | | Structural Characterization of Minor Ampullate Spidroin Domains and their Distinct Roles in Fibroin Solubility and Fiber Formation | | 分子名称: | Minor ampullate fibroin 1 | | 著者 | Yang, D, Gao, Z, Lin, Z, Huang, W, Lai, C, Fan, J. | | 登録日 | 2012-10-30 | | 公開日 | 2013-03-27 | | 最終更新日 | 2024-05-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structural characterization of minor ampullate spidroin domains and their distinct roles in fibroin solubility and fiber formation
Plos One, 8, 2013
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2MT3
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4XO1
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1BJH
 | | HAIRPIN LOOPS CONSISTING OF SINGLE ADENINE RESIDUES CLOSED BY SHEARED A(DOT)A AND G(DOT)G PAIRS FORMED BY THE DNA TRIPLETS AAA AND GAG: SOLUTION STRUCTURE OF THE D(GTACAAAGTAC) HAIRPIN, NMR, 16 STRUCTURES | | 分子名称: | DNA (5'-D(*GP*TP*AP*CP*AP*AP*AP*GP*TP*AP*C)-3') | | 著者 | Chou, S.-H, Zhu, L, Gao, Z, Cheng, J.-W, Reid, B.R. | | 登録日 | 1997-07-25 | | 公開日 | 1997-12-03 | | 最終更新日 | 2022-02-16 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Hairpin loops consisting of single adenine residues closed by sheared A.A and G.G pairs formed by the DNA triplets AAA and GAG: solution structure of the d(GTACAAAGTAC) hairpin.
J.Mol.Biol., 264, 1996
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2MA1
 | | Solution structure of HRDC1 domain of RecQ helicase from Deinococcus radiodurans | | 分子名称: | DNA helicase RecQ | | 著者 | Liu, S, Zhang, W, Gao, Z, Ming, Q, Hou, H, Lan, W, Wu, H, Cao, C, Dong, Y. | | 登録日 | 2013-06-24 | | 公開日 | 2013-07-10 | | 最終更新日 | 2023-06-14 | | 実験手法 | SOLUTION NMR | | 主引用文献 | NMR structure of the N-terminal-most HRDC1 domain of RecQ helicase from Deinococcus radiodurans
To be Published
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4ZW0
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4FVD
 | | Crystal structure of EV71 2A proteinase C110A mutant in complex with substrate | | 分子名称: | 10-mer peptide from 2A proteinase, 2A proteinase, ZINC ION | | 著者 | Cai, Q, Muhammad, Y, Liu, W, Gao, Z, Peng, X, Cai, Y, Wu, C, Zheng, Q, Li, J, Lin, T. | | 登録日 | 2012-06-29 | | 公開日 | 2013-06-19 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.66 Å) | | 主引用文献 | Conformational Plasticity of 2A Proteinase from Enterovirus 71
J.Virol., 87, 2013
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4FVB
 | | Crystal structure of EV71 2A proteinase C110A mutant | | 分子名称: | 2A proteinase, ZINC ION | | 著者 | Cai, Q, Muhammad, Y, Liu, W, Gao, Z, Peng, X, Cai, Y, Wu, C, Zheng, Q, Li, J, Lin, T. | | 登録日 | 2012-06-29 | | 公開日 | 2013-06-19 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Conformational Plasticity of 2A Proteinase from Enterovirus 71
J.Virol., 87, 2013
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4LX3
 | | Conserved Residues that Modulate Protein trans-Splicing of Npu DnaE Split Intein | | 分子名称: | DNA polymerase III, alpha subunit, Nucleic acid binding, ... | | 著者 | Wu, Q, Gao, Z, Wei, Y, Ma, G, Zheng, Y, Dong, Y, Liu, Y. | | 登録日 | 2013-07-29 | | 公開日 | 2014-06-25 | | 最終更新日 | 2022-08-24 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Conserved residues that modulate protein trans-splicing of Npu DnaE split intein.
Biochem.J., 461, 2014
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4MMJ
 | | crystal structure of YafQ from E.coli strain BL21(DE3) | | 分子名称: | Addiction module toxin, RelE/StbE family, SULFATE ION | | 著者 | Liang, Y, Gao, Z, Liu, Q, Dong, Y. | | 登録日 | 2013-09-09 | | 公開日 | 2014-06-25 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structural and Functional Characterization of Escherichia coli Toxin-Antitoxin Complex DinJ-YafQ
J.Biol.Chem., 289, 2014
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6ITW
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6JPI
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6LB3
 | | Crystal structure of PA4674 in complex with its operator DNA (18bp) from Pseudomonas aeruginosa | | 分子名称: | DNA (5'-D(P*AP*CP*CP*CP*TP*TP*AP*AP*CP*GP*TP*TP*AP*AP*GP*CP*GP*T)-3'), DNA (5'-D(P*AP*CP*GP*CP*TP*TP*AP*AP*CP*GP*TP*TP*AP*AP*GP*GP*GP*T)-3'), HTH cro/C1-type domain-containing protein, ... | | 著者 | Liu, Y, Zhang, H, Gao, Z, Dong, Y. | | 登録日 | 2019-11-13 | | 公開日 | 2020-11-18 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.497 Å) | | 主引用文献 | Crystal structure of PA4674 in complex with its operator DNA (18bp) from Pseudomonas aeruginosa
To Be Published
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6M10
 | | Crystal structure of PA4853 (Fis) from Pseudomonas aeruginosa | | 分子名称: | Putative Fis-like DNA-binding protein | | 著者 | Zhang, H, Gao, Z, Zhou, J, Dong, Y. | | 登録日 | 2020-02-24 | | 公開日 | 2020-05-13 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.985 Å) | | 主引用文献 | Crystal structure of the nucleoid-associated protein Fis (PA4853) from Pseudomonas aeruginosa.
Acta Crystallogr.,Sect.F, 76, 2020
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5YOX
 | | HD domain-containing protein YGK1(YGL101W) | | 分子名称: | HD domain-containing protein YGL101W, ZINC ION | | 著者 | Yang, J, Wang, F, Gao, Z, Zhou, K, Liu, Q. | | 登録日 | 2017-10-31 | | 公開日 | 2018-11-21 | | 実験手法 | X-RAY DIFFRACTION (2.61 Å) | | 主引用文献 | HD domain-containing protein YGK1(YGL101W)
To Be Published
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7YHS
 | | Structure of Csy-AcrIF4-dsDNA | | 分子名称: | AcrIF4, CRISPR type I-F/YPEST-associated protein Csy2, CRISPR-associated protein Csy3, ... | | 著者 | Feng, Y, Zhang, L.X. | | 登録日 | 2022-07-14 | | 公開日 | 2023-03-29 | | 実験手法 | ELECTRON MICROSCOPY (3.37 Å) | | 主引用文献 | Anti-CRISPR protein AcrIF4 inhibits the type I-F CRISPR-Cas surveillance complex by blocking nuclease recruitment and DNA cleavage.
J.Biol.Chem., 298, 2022
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4NK5
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7QJU
 | | EED in complex with PRC2 allosteric inhibitor compound 7 | | 分子名称: | CHLORIDE ION, Histone-lysine N-methyltransferase EZH2, N-(2,3-dihydro-1-benzofuran-4-ylmethyl)-8-[4-[(dimethylamino)methyl]phenyl]-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine, ... | | 著者 | Zhao, K, Zhao, M, Luo, X, Zhang, H, Scheufler, C. | | 登録日 | 2021-12-17 | | 公開日 | 2022-04-13 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Discovery of the Clinical Candidate MAK683: An EED-Directed, Allosteric, and Selective PRC2 Inhibitor for the Treatment of Advanced Malignancies.
J.Med.Chem., 65, 2022
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7QJG
 | | EED in complex with PRC2 allosteric inhibitor compound 6 | | 分子名称: | CHLORIDE ION, Histone-lysine N-methyltransferase EZH2, N-(2,3-dihydro-1-benzofuran-7-ylmethyl)-8-[4-[(dimethylamino)methyl]phenyl]-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine, ... | | 著者 | Zhao, K, Zhao, M, Luo, X, Zhang, H, Scheufler, C. | | 登録日 | 2021-12-16 | | 公開日 | 2022-04-13 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Discovery of the Clinical Candidate MAK683: An EED-Directed, Allosteric, and Selective PRC2 Inhibitor for the Treatment of Advanced Malignancies.
J.Med.Chem., 65, 2022
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7QK4
 | | EED in complex with PRC2 allosteric inhibitor compound 22 (MAK683) | | 分子名称: | CHLORIDE ION, Histone-lysine N-methyltransferase EZH2, N-[(5-fluoranyl-2,3-dihydro-1-benzofuran-4-yl)methyl]-8-(2-methylpyridin-3-yl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine, ... | | 著者 | Zhao, K, Zhao, M, Luo, X, Zhang, H, Scheufler, C. | | 登録日 | 2021-12-17 | | 公開日 | 2022-04-13 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.602 Å) | | 主引用文献 | Discovery of the Clinical Candidate MAK683: An EED-Directed, Allosteric, and Selective PRC2 Inhibitor for the Treatment of Advanced Malignancies.
J.Med.Chem., 65, 2022
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6WMW
 | | GFRAL receptor bound with two antibody Fabs (3P10, 25M22) | | 分子名称: | FAB25M22 heavy chain fragment, FAB25M22 light chain, FAB3P10 heavy chain fragment, ... | | 著者 | White, A, Lakshminarasimhan, D, Olland, A, Suto, R.K. | | 登録日 | 2020-04-21 | | 公開日 | 2020-07-15 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.91 Å) | | 主引用文献 | Antibody-mediated inhibition of GDF15-GFRAL activity reverses cancer cachexia in mice.
Nat Med, 26, 2020
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4XO2
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4U93
 | | Crystal Structure of Hsp90-alpha N-domain Bound to the Inhibitor NVP-HSP990 | | 分子名称: | (7R)-2-amino-7-[4-fluoro-2-(6-methoxypyridin-2-yl)phenyl]-4-methyl-7,8-dihydropyrido[4,3-d]pyrimidin-5(6H)-one, Heat shock protein HSP 90-alpha | | 著者 | Bellamacina, C.R, Shafer, C.M, Bussiere, D. | | 登録日 | 2014-08-05 | | 公開日 | 2014-11-19 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | Design, Structure-Activity Relationship, and in Vivo Characterization of the Development Candidate NVP-HSP990.
J.Med.Chem., 57, 2014
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4W7T
 | | Crystal Structure of Hsp90-alpha N-domain Bound to the Inhibitor NVP-HSP990 | | 分子名称: | (7S)-2-amino-4-methyl-7-phenyl-7,8-dihydroquinazolin-5(6H)-one, Heat shock protein HSP 90-alpha | | 著者 | Bellamacina, C.R, Shafer, C.M, Bussiere, D. | | 登録日 | 2014-08-22 | | 公開日 | 2014-11-26 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Design, Structure-Activity Relationship, and in Vivo Characterization of the Development Candidate NVP-HSP990.
J.Med.Chem., 57, 2014
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5C2O
 | | Crystal structure of Streptococcus mutans Deoxycytidylate Deaminase complexed with dTTP | | 分子名称: | MAGNESIUM ION, Putative deoxycytidylate deaminase, THYMIDINE-5'-TRIPHOSPHATE, ... | | 著者 | Li, Y.H, Gao, Z.Q, Hou, H.F, Dong, Y.H. | | 登録日 | 2015-06-16 | | 公開日 | 2016-07-13 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | Mechanism of the allosteric regulation of Streptococcus mutans 2'-deoxycytidylate deaminase.
Acta Crystallogr D Struct Biol, 72, 2016
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