4JWX
 
 | | GluN2A ligand-binding core in complex with propyl-NHP5G | | Descriptor: | (2R)-amino(1-hydroxy-4-propyl-1H-pyrazol-5-yl)ethanoic acid, GluN2A | | Authors: | Hansen, K.B, Tajima, N, Risgaard, R, Perszyk, R.E, Jorgensen, L, Vance, K.M, Ogden, K.K, Clausen, R.P, Furukawa, H, Traynelis, S.F. | | Deposit date: | 2013-03-27 | | Release date: | 2013-05-29 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Structural determinants of agonist efficacy at the glutamate binding site of N-methyl-d-aspartate receptors.
Mol.Pharmacol., 84, 2013
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8E94
 | | PYD-106-bound Human GluN1a-GluN2C NMDA receptor in intact conformation | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Chou, T.-H, Furukawa, H. | | Deposit date: | 2022-08-26 | | Release date: | 2022-12-07 | | Last modified: | 2022-12-14 | | Method: | ELECTRON MICROSCOPY (3.72 Å) | | Cite: | Structural insights into assembly and function of GluN1-2C, GluN1-2A-2C, and GluN1-2D NMDARs.
Mol.Cell, 82, 2022
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8E93
 | | D-cycloserine and glutamate bound Human GluN1a-GluN2C NMDA receptor in splayed conformation | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ... | | Authors: | Chou, T.-H, Furukawa, H. | | Deposit date: | 2022-08-26 | | Release date: | 2022-12-07 | | Last modified: | 2022-12-14 | | Method: | ELECTRON MICROSCOPY (3.71 Å) | | Cite: | Structural insights into assembly and function of GluN1-2C, GluN1-2A-2C, and GluN1-2D NMDARs.
Mol.Cell, 82, 2022
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8E97
 | | PYD-106-bound Human GluN1a-GluN2C NMDA receptor in splayed conformation | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ... | | Authors: | Chou, T.-H, Furukawa, H. | | Deposit date: | 2022-08-26 | | Release date: | 2022-12-07 | | Last modified: | 2022-12-14 | | Method: | ELECTRON MICROSCOPY (4.19 Å) | | Cite: | Structural insights into assembly and function of GluN1-2C, GluN1-2A-2C, and GluN1-2D NMDARs.
Mol.Cell, 82, 2022
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8E99
 | | Human GluN1a-GluN2A-GluN2C triheteromeric NMDA receptor in complex with Nb-4 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ... | | Authors: | Chou, T.-H, Furukawa, H. | | Deposit date: | 2022-08-26 | | Release date: | 2022-12-07 | | Last modified: | 2022-12-14 | | Method: | ELECTRON MICROSCOPY (4.24 Å) | | Cite: | Structural insights into assembly and function of GluN1-2C, GluN1-2A-2C, and GluN1-2D NMDARs.
Mol.Cell, 82, 2022
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8E92
 | | D-cycloserine and glutamate bound Human GluN1a-GluN2C NMDA receptor in intact conformation | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ... | | Authors: | Chou, T.-H, Furukawa, H. | | Deposit date: | 2022-08-26 | | Release date: | 2022-12-07 | | Last modified: | 2022-12-14 | | Method: | ELECTRON MICROSCOPY (3.96 Å) | | Cite: | Structural insights into assembly and function of GluN1-2C, GluN1-2A-2C, and GluN1-2D NMDARs.
Mol.Cell, 82, 2022
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8E98
 | | D-cycloserine and glutamate bound Human GluN1a-GluN2C NMDA receptor in nanodisc - intact conformation | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, NMDA 1, ... | | Authors: | Chou, T.-H, Furukawa, H. | | Deposit date: | 2022-08-26 | | Release date: | 2022-12-07 | | Last modified: | 2022-12-14 | | Method: | ELECTRON MICROSCOPY (3.75 Å) | | Cite: | Structural insights into assembly and function of GluN1-2C, GluN1-2A-2C, and GluN1-2D NMDARs.
Mol.Cell, 82, 2022
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8G18
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3QEL
 | | Crystal structure of amino terminal domains of the NMDA receptor subunit GluN1 and GluN2B in complex with ifenprodil | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-[(1R,2S)-2-(4-benzylpiperidin-1-yl)-1-hydroxypropyl]phenol, Glutamate [NMDA] receptor subunit epsilon-2, ... | | Authors: | Karakas, E, Simorowski, N, Furukawa, H. | | Deposit date: | 2011-01-20 | | Release date: | 2011-06-15 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Subunit arrangement and phenylethanolamine binding in GluN1/GluN2B NMDA receptors.
Nature, 475, 2011
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3QEK
 | | Crystal structure of amino terminal domain of the NMDA receptor subunit GluN1 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, NMDA glutamate receptor subunit, POTASSIUM ION, ... | | Authors: | Karakas, E, Simorowski, N, Furukawa, H. | | Deposit date: | 2011-01-20 | | Release date: | 2011-06-15 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.001 Å) | | Cite: | Subunit arrangement and phenylethanolamine binding in GluN1/GluN2B NMDA receptors.
Nature, 475, 2011
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3QEM
 | | Crystal structure of amino terminal domains of the NMDA receptor subunit GluN1 and GluN2B in complex with Ro 25-6981 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-[(1R,2S)-3-(4-benzylpiperidin-1-yl)-1-hydroxy-2-methylpropyl]phenol, Glutamate [NMDA] receptor subunit epsilon-2, ... | | Authors: | Karakas, E, Simorowski, N, Furukawa, H. | | Deposit date: | 2011-01-20 | | Release date: | 2011-06-15 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (3.003 Å) | | Cite: | Subunit arrangement and phenylethanolamine binding in GluN1/GluN2B NMDA receptors.
Nature, 475, 2011
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6E7R
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5TPZ
 | | Crystal structure of amino terminal domains of the NMDA receptor subunit GluN1 and GluN2B in apo closed state | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, NMDA 2B, ... | | Authors: | Romero-Hernandez, A, Simorwski, N, Karakas, E, Furukawa, H. | | Deposit date: | 2016-10-21 | | Release date: | 2016-12-14 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (3.095 Å) | | Cite: | Molecular Basis for Subtype Specificity and High-Affinity Zinc Inhibition in the GluN1-GluN2A NMDA Receptor Amino-Terminal Domain.
Neuron, 92, 2016
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5U8C
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5TQ0
 | | Crystal structure of amino terminal domains of the NMDA receptor subunit GluN1 and GluN2A in the presence of EDTA | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, FAB, HEAVY CHAIN, ... | | Authors: | Romero-Hernandez, A, Simorowski, N, Karakas, E, Furukawa, H. | | Deposit date: | 2016-10-21 | | Release date: | 2016-12-14 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Molecular Basis for Subtype Specificity and High-Affinity Zinc Inhibition in the GluN1-GluN2A NMDA Receptor Amino-Terminal Domain.
Neuron, 92, 2016
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5TPW
 | | Crystal structure of amino terminal domains of the NMDA receptor subunit GluN1 and GluN2A in complex with zinc at the GluN2A | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, FAB, HEAVY CHAIN, ... | | Authors: | Romero-Hernandez, A, Simorowski, N, Karakas, E, Furukawa, H. | | Deposit date: | 2016-10-21 | | Release date: | 2016-12-14 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.909 Å) | | Cite: | Molecular Basis for Subtype Specificity and High-Affinity Zinc Inhibition in the GluN1-GluN2A NMDA Receptor Amino-Terminal Domain.
Neuron, 92, 2016
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5TQ2
 | | Crystal structure of amino terminal domains of the NMDA receptor subunit GluN1 and GluN2A in complex with zinc at GluN1 and GluN2A | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, FAB, HEAVY CHAIN, ... | | Authors: | Romero-Hernandez, A, Simorowski, N, Karakas, E, Furukawa, H. | | Deposit date: | 2016-10-21 | | Release date: | 2016-12-14 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (3.289 Å) | | Cite: | Molecular Basis for Subtype Specificity and High-Affinity Zinc Inhibition in the GluN1-GluN2A NMDA Receptor Amino-Terminal Domain.
Neuron, 92, 2016
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8GMP
 | | Cryo-EM structure of octameric human CALHM1 with a I109W point mutation | | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Calcium homeostasis modulator protein 1 | | Authors: | Syrjanen, J.L, Furukawa, H. | | Deposit date: | 2023-03-27 | | Release date: | 2023-07-26 | | Last modified: | 2024-05-01 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Structure of human CALHM1 reveals key locations for channel regulation and blockade by ruthenium red.
Nat Commun, 14, 2023
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8GMR
 | | Cryo-EM structure of octameric human CALHM1 | | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Calcium homeostasis modulator protein 1 | | Authors: | Syrjanen, J.L, Furukawa, H. | | Deposit date: | 2023-03-27 | | Release date: | 2023-07-26 | | Last modified: | 2024-05-01 | | Method: | ELECTRON MICROSCOPY (3.76 Å) | | Cite: | Structure of human CALHM1 reveals key locations for channel regulation and blockade by ruthenium red.
Nat Commun, 14, 2023
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8GMQ
 | | Chicken CALHM1 purified from mammalian cells | | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Calcium homeostasis modulator 1 | | Authors: | Syrjanen, J.L, Furukawa, H. | | Deposit date: | 2023-03-27 | | Release date: | 2023-07-26 | | Last modified: | 2024-05-01 | | Method: | ELECTRON MICROSCOPY (3.36 Å) | | Cite: | Structure of human CALHM1 reveals key locations for channel regulation and blockade by ruthenium red.
Nat Commun, 14, 2023
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3OEM
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3JPY
 | | Crystal structure of the zinc-bound amino terminal domain of the NMDA receptor subunit NR2B | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Glutamate [NMDA] receptor subunit epsilon-2, ... | | Authors: | Karakas, E, Simorowski, N, Furukawa, H. | | Deposit date: | 2009-09-04 | | Release date: | 2009-12-08 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (3.209 Å) | | Cite: | Structure of the zinc-bound amino-terminal domain of the NMDA receptor NR2B subunit.
Embo J., 28, 2009
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3JPW
 | | Crystal structure of amino terminal domain of the NMDA receptor subunit NR2B | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Glutamate [NMDA] receptor subunit epsilon-2, ... | | Authors: | Karakas, E, Simorowski, N, Furukawa, H. | | Deposit date: | 2009-09-04 | | Release date: | 2009-12-08 | | Last modified: | 2021-10-13 | | Method: | X-RAY DIFFRACTION (2.803 Å) | | Cite: | Structure of the zinc-bound amino-terminal domain of the NMDA receptor NR2B subunit.
Embo J., 28, 2009
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3OEL
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3OEK
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