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1L8A
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BU of 1l8a by Molmil
E. COLI PYRUVATE DEHYDROGENASE
分子名称: MAGNESIUM ION, Pyruvate dehydrogenase E1 component, THIAMINE DIPHOSPHATE
著者Furey, W, Arjunan, P.
登録日2002-03-19
公開日2002-07-24
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Structure of the pyruvate dehydrogenase multienzyme complex E1 component from Escherichia coli at 1.85 A resolution.
Biochemistry, 41, 2002
2QTC
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E. coli Pyruvate dehydrogenase E1 component E401K mutant with phosphonolactylthiamin diphosphate
分子名称: 3-[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]-2-{(1S)-1-HYDROXY-1-[(R)-HYDROXY(METHOXY)PHOSPHORYL]ETHYL}-5-(2-{[(S)-HYDROXY(PHOSPHONOOXY)PHOSPHORYL]OXY}ETHYL)-4-METHYL-1,3-THIAZOL-3-IUM, MAGNESIUM ION, Pyruvate dehydrogenase E1 component
著者Furey, W, Arjunan, P, Chandrasekhar, K.
登録日2007-08-01
公開日2007-08-14
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.77 Å)
主引用文献A Dynamic Loop at the Active Center of the Escherichia coli Pyruvate Dehydrogenase Complex E1 Component Modulates Substrate Utilization and Chemical Communication with the E2 Component
J.Biol.Chem., 282, 2007
1PVD
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CRYSTAL STRUCTURE OF THE THIAMIN DIPHOSPHATE DEPENDENT ENZYME PYRUVATE DECARBOXYLASE FROM THE YEAST SACCHAROMYCES CEREVISIAE AT 2.3 ANGSTROMS RESOLUTION
分子名称: MAGNESIUM ION, PYRUVATE DECARBOXYLASE, THIAMINE DIPHOSPHATE
著者Furey, W, Arjunan, P.
登録日1995-04-20
公開日1995-07-31
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal structure of the thiamin diphosphate-dependent enzyme pyruvate decarboxylase from the yeast Saccharomyces cerevisiae at 2.3 A resolution.
J.Mol.Biol., 256, 1996
1PYD
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BU of 1pyd by Molmil
CATALYTIC CENTERS IN THE THIAMIN DIPHOSPHATE DEPENDENT ENZYME PYRUVATE DECARBOXYLASE AT 2.4 ANGSTROMS RESOLUTION
分子名称: MAGNESIUM ION, PYRUVATE DECARBOXYLASE, THIAMINE DIPHOSPHATE
著者Furey, W, Dyda, F.
登録日1993-03-23
公開日1994-04-30
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Catalytic centers in the thiamin diphosphate dependent enzyme pyruvate decarboxylase at 2.4-A resolution.
Biochemistry, 32, 1993
4QOY
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Novel binding motif and new flexibility revealed by structural analysis of a pyruvate dehydrogenase-dihydrolipoyl acetyltransferase sub-complex from the escherichia coli pyruvate dehydrogenase multi-enzyme complex
分子名称: Pyruvate dehydrogenase (Dihydrolipoyltransacetylase component), Pyruvate dehydrogenase E1 component
著者Furey, W, Arjunan, P.
登録日2014-06-20
公開日2014-09-17
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Novel Binding Motif and New Flexibility Revealed by Structural Analyses of a Pyruvate Dehydrogenase-Dihydrolipoyl Acetyltransferase Subcomplex from the Escherichia coli Pyruvate Dehydrogenase Multienzyme Complex.
J.Biol.Chem., 289, 2014
2RHE
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BU of 2rhe by Molmil
STRUCTURE OF A NOVEL BENCE-JONES PROTEIN (RHE) FRAGMENT AT 1.6 ANGSTROMS RESOLUTION
分子名称: BENCE-JONES PROTEIN RHE (LIGHT CHAIN)
著者Fureyjunior, W, Wang, B.C, Yoo, C.S, Sax, M.
登録日1983-06-13
公開日1983-09-15
最終更新日2017-11-29
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structure of a novel Bence-Jones protein (Rhe) fragment at 1.6 A resolution.
J.Mol.Biol., 167, 1983
2QTA
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BU of 2qta by Molmil
E. coli Pyruvate dehydrogenase E1 component E401K mutant with thiamin diphosphate
分子名称: MAGNESIUM ION, Pyruvate dehydrogenase E1 component, THIAMINE DIPHOSPHATE
著者Furey, W, Arjunan, P, Chandrasekhar, K.
登録日2007-08-01
公開日2007-08-14
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献A Dynamic Loop at the Active Center of the Escherichia coli Pyruvate Dehydrogenase Complex E1 Component Modulates Substrate Utilization and Chemical Communication with the E2 Component
J.Biol.Chem., 282, 2007
2IEA
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E. coli pyruvate dehydrogenase
分子名称: MAGNESIUM ION, Pyruvate dehydrogenase E1 component, THIAMINE DIPHOSPHATE
著者Furey, W, Arjunan, P.
登録日2006-09-18
公開日2006-10-03
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Structure of the pyruvate dehydrogenase multienzyme complex E1 component from Escherichia coli at 1.85 A resolution.
Biochemistry, 41, 2002
2G28
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E. Coli Pyruvate Dehydrogenase H407A variant Phosphonolactylthiamin Diphosphate Complex
分子名称: 3-[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]-2-{(1S)-1-HYDROXY-1-[(R)-HYDROXY(METHOXY)PHOSPHORYL]ETHYL}-5-(2-{[(S)-HYDROXY(PHOSPHONOOXY)PHOSPHORYL]OXY}ETHYL)-4-METHYL-1,3-THIAZOL-3-IUM, MAGNESIUM ION, Pyruvate dehydrogenase E1 component
著者Furey, W, Arjunan, P, Chandrasekhar, K.
登録日2006-02-15
公開日2006-04-25
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献A Thiamin-bound, Pre-decarboxylation Reaction Intermediate Analogue in the Pyruvate Dehydrogenase E1 Subunit Induces Large Scale Disorder-to-Order Transformations in the Enzyme and Reveals Novel Structural Features in the Covalently Bound Adduct.
J.Biol.Chem., 281, 2006
2G25
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E. Coli Pyruvate Dehydrogenase Phosphonolactylthiamin Diphosphate Complex
分子名称: 3-[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]-2-{(1S)-1-HYDROXY-1-[(R)-HYDROXY(METHOXY)PHOSPHORYL]ETHYL}-5-(2-{[(S)-HYDROXY(PHOSPHONOOXY)PHOSPHORYL]OXY}ETHYL)-4-METHYL-1,3-THIAZOL-3-IUM, MAGNESIUM ION, PHOSPHATE ION, ...
著者Furey, W, Arjunan, P, Chandrasekhar, K.
登録日2006-02-15
公開日2006-04-25
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献A Thiamin-bound, Pre-decarboxylation Reaction Intermediate Analogue in the Pyruvate Dehydrogenase E1 Subunit Induces Large Scale Disorder-to-Order Transformations in the Enzyme and Reveals Novel Structural Features in the Covalently Bound Adduct.
J.Biol.Chem., 281, 2006
2G67
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E. Coli Pyruvate Dehydrogenase E1 Component (Apoenzyme)
分子名称: Pyruvate dehydrogenase E1 component
著者Furey, W, Chandrasekhar, K, Arjunan, P.
登録日2006-02-24
公開日2006-09-12
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.32 Å)
主引用文献Active-site changes in the pyruvate dehydrogenase multienzyme complex E1 apoenzyme component from Escherichia coli observed at 2.32 A resolution.
ACTA CRYSTALLOGR.,SECT.D, 62, 2006
3LPL
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BU of 3lpl by Molmil
E. coli pyruvate dehydrogenase complex E1 component E571A mutant
分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, MAGNESIUM ION, PHOSPHATE ION, ...
著者Furey, W.
登録日2010-02-05
公開日2010-03-02
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Communication between thiamin cofactors in the Escherichia coli pyruvate dehydrogenase complex E1 component active centers: evidence for a "direct pathway" between the 4'-aminopyrimidine N1' atoms.
J.Biol.Chem., 285, 2010
3LQ2
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BU of 3lq2 by Molmil
E. coli pyruvate dehydrogenase complex E1 E235A mutant with low TDP concentration
分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, MAGNESIUM ION, PHOSPHATE ION, ...
著者Furey, W.
登録日2010-02-08
公開日2010-03-02
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.96 Å)
主引用文献Communication between thiamin cofactors in the Escherichia coli pyruvate dehydrogenase complex E1 component active centers: evidence for a "direct pathway" between the 4'-aminopyrimidine N1' atoms.
J.Biol.Chem., 285, 2010
3LQ4
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E. coli pyruvate dehydrogenase complex E1 E235A mutant with high TDP concentration
分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, MAGNESIUM ION, PHOSPHATE ION, ...
著者Furey, W.
登録日2010-02-08
公開日2010-03-02
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.98 Å)
主引用文献Communication between thiamin cofactors in the Escherichia coli pyruvate dehydrogenase complex E1 component active centers: evidence for a "direct pathway" between the 4'-aminopyrimidine N1' atoms.
J.Biol.Chem., 285, 2010
1CCD
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BU of 1ccd by Molmil
REFINED STRUCTURE OF RAT CLARA CELL 17 KDA PROTEIN AT 3.0 ANGSTROMS RESOLUTION
分子名称: CLARA CELL 17 kD PROTEIN, SULFATE ION
著者Umland, T.C, Swaminathan, S, Furey, W, Singh, G, Pletcher, J, Sax, M.
登録日1991-09-17
公開日1994-01-31
最終更新日2017-11-29
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Refined structure of rat Clara cell 17 kDa protein at 3.0 A resolution.
J.Mol.Biol., 224, 1992
5K79
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Structure and anti-HIV activity of CYT-CVNH, a new cyanovirin-n homolog
分子名称: 1,2-ETHANEDIOL, Cyanovirin-N domain protein, DI(HYDROXYETHYL)ETHER
著者Matei, E, Basu, R, Furey, W, Shi, J, Calnan, C, Aiken, C, Gronenborn, A.M.
登録日2016-05-25
公開日2016-07-20
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structure and Glycan Binding of a New Cyanovirin-N Homolog.
J.Biol.Chem., 291, 2016
4GK9
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Crystal structure of Burkholderia oklahomensis agglutinin (BOA) bound to 3a,6a-mannopentaose
分子名称: IMIDAZOLE, SODIUM ION, agglutinin (BOA), ...
著者Whitley, M.J, Furey, W, Gronenborn, A.M.
登録日2012-08-10
公開日2013-05-08
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Burkholderia oklahomensis agglutinin is a canonical two-domain OAA-family lectin: structures, carbohydrate binding and anti-HIV activity.
Febs J., 280, 2013
6CER
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BU of 6cer by Molmil
Human pyruvate dehydrogenase complex E1 component V138M mutation
分子名称: MAGNESIUM ION, Pyruvate dehydrogenase E1 component subunit alpha, somatic form, ...
著者Whitley, M.J, Arjunan, P, Furey, W.
登録日2018-02-12
公開日2018-07-11
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.69 Å)
主引用文献Pyruvate dehydrogenase complex deficiency is linked to regulatory loop disorder in the alpha V138M variant of human pyruvate dehydrogenase.
J. Biol. Chem., 293, 2018
4GU8
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Crystal Structure of Burkholderia oklahomensis agglutinin (BOA)
分子名称: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, Burkholderia oklahomensis agglutinin (BOA), GLYCEROL
著者Whitley, M.J, Furey, W, Gronenborn, A.M.
登録日2012-08-29
公開日2013-05-08
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Burkholderia oklahomensis agglutinin is a canonical two-domain OAA-family lectin: structures, carbohydrate binding and anti-HIV activity.
Febs J., 280, 2013
6CFO
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BU of 6cfo by Molmil
HUMAN PYRUVATE DEHYDROGENASE E1 COMPONENT COMPLEX WITH COVALENT TDP ADDUCT ACETYL PHOSPHINATE
分子名称: 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-{(1S)-1-hydroxy-1-[(R)-hydroxy(oxo)-lambda~5~-phosphanyl]ethyl}-5-(2-{[(S)-hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3-thiazol-3-ium, MAGNESIUM ION, Pyruvate dehydrogenase E1 component subunit alpha, ...
著者ARJUNAN, P, WHITLEY, M.J, FUREY, W.
登録日2018-02-15
公開日2018-07-11
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Pyruvate dehydrogenase complex deficiency is linked to regulatory loop disorder in the alpha V138M variant of human pyruvate dehydrogenase.
J. Biol. Chem., 293, 2018
3CZZ
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Crystal structure of Cyanovirin-N domain B mutant
分子名称: Cyanovirin-N
著者Matei, E, Furey, W, Gronenborn, A.M.
登録日2008-04-30
公開日2008-08-19
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.36 Å)
主引用文献Solution and crystal structures of a sugar binding site mutant of cyanovirin-N: no evidence of domain swapping.
Structure, 16, 2008
2RP3
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Solution Structure of Cyanovirin-N Domain B Mutant
分子名称: Cyanovirin-N
著者Matei, E, Furey, W, Gronenborn, A.M.
登録日2008-04-30
公開日2008-08-19
最終更新日2021-11-10
実験手法SOLUTION NMR
主引用文献Solution and crystal structures of a sugar binding site mutant of cyanovirin-N: no evidence of domain swapping
Structure, 16, 2008
1RP7
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E. COLI PYRUVATE DEHYDROGENASE INHIBITOR COMPLEX
分子名称: 2-{3-[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]-4-METHYL-2-OXO-2,3-DIHYDRO-1,3-THIAZOL-5-YL}ETHYL TRIHYDROGEN DIPHOSPHATE, MAGNESIUM ION, Pyruvate dehydrogenase E1 component
著者Arjunan, P, Chandrasekhar, K, Furey, W.
登録日2003-12-03
公開日2004-03-16
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.09 Å)
主引用文献Structural Determinants of Enzyme Binding Affinity: The E1 Component of Pyruvate Dehydrogenase from Escherichia coli in Complex with the Inhibitor Thiamin Thiazolone Diphosphate.
Biochemistry, 43, 2004
3LHC
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Crystal structure of cyanovirin-n swapping domain b mutant
分子名称: Cyanovirin-N, PHOSPHATE ION, SODIUM ION
著者Matei, E, Zheng, A, Furey, W, Rose, J, Aiken, C, Gronenborn, A.M.
登録日2010-01-21
公開日2010-02-09
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.34 Å)
主引用文献Anti-HIV activity of defective cyanovirin-N mutants is restored by dimerization.
J.Biol.Chem., 285, 2010
3OBL
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Crystal structure of the potent anti-HIV cyanobacterial lectin from Oscillatoria Agardhii
分子名称: 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, Lectin
著者Koharudin, L.M.I, Furey, W, Gronenborn, A.M.
登録日2010-08-06
公開日2010-10-20
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献Novel fold and carbohydrate specificity of the potent anti-HIV cyanobacterial lectin from Oscillatoria agardhii.
J.Biol.Chem., 286, 2011

 

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