6CFO
HUMAN PYRUVATE DEHYDROGENASE E1 COMPONENT COMPLEX WITH COVALENT TDP ADDUCT ACETYL PHOSPHINATE
Summary for 6CFO
Entry DOI | 10.2210/pdb6cfo/pdb |
Related | 6CER |
Descriptor | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial, Pyruvate dehydrogenase E1 component subunit beta, mitochondrial, 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-{(1S)-1-hydroxy-1-[(R)-hydroxy(oxo)-lambda~5~-phosphanyl]ethyl}-5-(2-{[(S)-hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3-thiazol-3-ium, ... (5 entities in total) |
Functional Keywords | thiamin pyrophosphate, acetyl phosphinate, inhibitor, pyruvate dehydrogenase, oxidoreductase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 157237.95 |
Authors | ARJUNAN, P.,WHITLEY, M.J.,FUREY, W. (deposition date: 2018-02-15, release date: 2018-07-11, Last modification date: 2023-10-04) |
Primary citation | Whitley, M.J.,Arjunan, P.,Nemeria, N.S.,Korotchkina, L.G.,Park, Y.H.,Patel, M.S.,Jordan, F.,Furey, W. Pyruvate dehydrogenase complex deficiency is linked to regulatory loop disorder in the alpha V138M variant of human pyruvate dehydrogenase. J. Biol. Chem., 293:13204-13213, 2018 Cited by PubMed: 29970614DOI: 10.1074/jbc.RA118.003996 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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