1RP7

E. COLI PYRUVATE DEHYDROGENASE INHIBITOR COMPLEX

Summary for 1RP7

• Entry DOI: 10.2210/pdb1rp7/pdb
• Related: 1L8A
• Descriptor: Pyruvate dehydrogenase E1 component, MAGNESIUM ION, 2-{3-[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]-4-METHYL-2-OXO-2,3-DIHYDRO-1,3-THIAZOL-5-YL}ETHYL TRIHYDROGEN DIPHOSPHATE, ... (4 entities in total)
• Functional Keywords: thdp, thiamin-thiazolone diphosphate, pyruvate dehydrogenase, oxidoreductase
• Biological source: Escherichia coli, Escherichia coli O157:H7 (,)
• Total number of polymer chains: 2
• Total formula weight: 200243.55

Authors

Arjunan, P.,Chandrasekhar, K.,Furey, W. (deposition date: 2003-12-03, release date: 2004-03-16, Last modification date: 2023-08-23)

• Primary citation: Arjunan, P.,Chandrasekhar, K.,Sax, M.,Brunskill, A.,Nemeria, N.,Jordan, F.,Furey, W.; Structural Determinants of Enzyme Binding Affinity: The E1 Component of Pyruvate Dehydrogenase from Escherichia coli in Complex with the Inhibitor Thiamin Thiazolone Diphosphate.; Biochemistry, 43:2405-2411, 2004; PubMed: 14992577; DOI: 10.1021/bi030200y

Experimental method

X-RAY DIFFRACTION (2.09 Å)