2QTC

E. coli Pyruvate dehydrogenase E1 component E401K mutant with phosphonolactylthiamin diphosphate

Summary for 2QTC

Entry DOI	10.2210/pdb2qtc/pdb
Related	2G25 2G28 2IEA 2QTA
Descriptor	Pyruvate dehydrogenase E1 component, MAGNESIUM ION, 3-[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]-2-{(1S)-1-HYDROXY-1-[(R)-HYDROXY(METHOXY)PHOSPHORYL]ETHYL}-5-(2-{[(S)-HYDROXY(PHOSPHONOOXY)PHOSPHORYL]OXY}ETHYL)-4-METHYL-1,3-THIAZOL-3-IUM, ... (4 entities in total)
Functional Keywords	pyruvate dehydrogenase, thiamin diphosphate, glycolysis, magnesium, metal-binding, oxidoreductase, thiamine pyrophosphate
Biological source	Escherichia coli
Total number of polymer chains	2
Total formula weight	200489.82
Authors	Furey, W.,Arjunan, P.,Chandrasekhar, K. (deposition date: 2007-08-01, release date: 2007-08-14, Last modification date: 2023-08-30)
Primary citation	Kale, S.,Arjunan, P.,Furey, W.,Jordan, F. A Dynamic Loop at the Active Center of the Escherichia coli Pyruvate Dehydrogenase Complex E1 Component Modulates Substrate Utilization and Chemical Communication with the E2 Component J.Biol.Chem., 282:28106-28116, 2007 Cited by PubMed: 17635929 DOI: 10.1074/jbc.M704326200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.77 Å)

Structure validation