2QTC
E. coli Pyruvate dehydrogenase E1 component E401K mutant with phosphonolactylthiamin diphosphate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Pyruvate dehydrogenase E1 component | polymer | 886 | 99657.2 | 2 | UniProt (P0AFG8) Pfam (PF00456) Pfam (PF17831) Pfam (PF22613) | Escherichia coli | |
| 2 | C, E (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 3 | D, F (A, B) | 3-[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]-2-{(1S)-1-HYDROXY-1-[(R)-HYDROXY(METHOXY)PHOSPHORYL]ETHYL}-5-(2-{[(S)-HYDROXY(PHOSPHONOOXY)PHOSPHORYL]OXY}ETHYL)-4-METHYL-1,3-THIAZOL-3-IUM | non-polymer | 563.4 | 2 | Chemie (TDK) | |||
| 4 | G, H (A, B) | water | water | 18.0 | 394 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 886 (UniProt: P0AFG8)
| PDB | External Database | Details |
|---|---|---|
| Lys 401 | Glu 402 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 199314.5 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1175.4 | |
| All* | Total formula weight | 200489.8 |
